Update on Cancer Therapy

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: closed (30 June 2026) | Viewed by 480

Editor

Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Interests: lung cancer; liver cancer; cancer biotherapy

Special Issue Information

Dear Colleagues,

Cancer therapy continues to evolve, driven by advances in understanding tumor biology and the development of innovative treatments. Despite significant progress, formidable challenges such as therapy resistance, tumor heterogeneity, and metastatic recurrence remain major clinical hurdles. These limitations affect not only conventional chemotherapy but also modern approaches such as targeted agents and immunotherapies, often curtailing the durability of patient responses.

This Special Issue, titled “Update on Cancer Therapy”, aims to highlight cutting-edge research and comprehensive reviews on emerging therapeutic strategies. We welcome contributions that focus on novel molecular and immune targets, biomarker-driven treatment personalization, combination therapies, and innovative platforms such as cancer vaccines, CAR-T/NK cells, and nanomedicine. A key focus is on understanding and overcoming the mechanisms of primary and acquired resistance. By integrating multidisciplinary insights, this Special Issue seeks to foster the development of more effective and durable treatments, ultimately bridging transformative laboratory discoveries with clinical applications to improve patient outcomes.

Dr. Jian Ruan
Guest Editor

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Keywords

  • cancer
  • cancer immunotherapy
  • targeted therapy
  • ccancer vaccines
  • therapeutic agents
  • drug resistance mechanisms

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Published Papers (1 paper)

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Review

20 pages, 1103 KB  
Review
Navigating the Role of Radiotherapy for Extremity Soft Tissue Sarcomas
by Emmy Nyqvist, Christina Linder-Stragliotto, Jenny Lofgren and Panagiotis Tsagkozis
Biomedicines 2026, 14(8), 1744; https://doi.org/10.3390/biomedicines14081744 - 2 Aug 2026
Viewed by 113
Abstract
Background/Objectives: The basis for treatment of sarcoma is surgical resection. However, since the introduction of limb salvage surgery, guidelines recommend radiation as a complement to surgery for high-grade sarcomas. The aim of the present narrative review was to provide a comprehensive update [...] Read more.
Background/Objectives: The basis for treatment of sarcoma is surgical resection. However, since the introduction of limb salvage surgery, guidelines recommend radiation as a complement to surgery for high-grade sarcomas. The aim of the present narrative review was to provide a comprehensive update about the role of surgery and radiotherapy (RT) for extremity soft tissue sarcoma (ESTS), to increase both surgeons’ and oncologists’ understanding of radiation as an adjuvant to sarcoma surgery and to illuminate areas of uncertainty that requires further research. Methods: A search on PubMed using relevant MeSH terms was performed, focusing on original research, meta-analyses and review articles. Related articles were identified through snowballing. Results: The support for the use of radiotherapy in conjunction with limb salvage is strong. Complication profiles differ between pre- and postoperative RT and attempts to further limit these are both technological and surgical. Preoperative radiotherapy provides the best results regarding long-term complications so far. Hypo-fractionation is showing promise, but awaiting long-term results for complications remains an area of research rather than clinical practice. Particle beam therapy and internal radiation show effects on control, but due to technical and availability issues, their role is mainly in previously irradiated or inoperable tumors. Conclusions: Upcoming research into adjusted deliveries, doses and planning is anticipated. To further personalize treatment, studies into sarcoma subtypes are indicated. Full article
(This article belongs to the Special Issue Update on Cancer Therapy)
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