Special Issues

Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Medicinal Cannabis: Advances in Therapeutics and Clinical Applications
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 3328 | Submission Open
Keywords: medicinal cannabis; cannabidiol (CBD); cannabigerol (CBG); cannabinoid; cannabinol (CBN)
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Drug Resistance and Tumor Microenvironment in Human Cancers
edited by , and Marília Isabel Neto Figueira
submission deadline 31 Mar 2026 | 1 articles | Viewed by 2789 | Submission Open
Keywords: cancer therapy; drug resistance; tumor microenvironment; targeted therapy; precision medicine; cancer-related mechanisms
(This special issue belongs to the Section Cancer Biology and Oncology)
New Horizons in Enzyme Inhibitor Discovery: Targets, Design and Evaluation
edited by Chenzhou Hao, Jing Guo, Yin Sun and Tongchao Liu
submission deadline 31 Mar 2026 | 2 articles | Viewed by 2098 | Submission Open
Keywords: enzyme inhibitors; drug design; inhibitor screening; medicinal chemistry; targets validation; structure– activity relationship; structure– property relationship
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advanced Research in Thyroid and Parathyroid Diseases
edited by Anping Su
submission deadline 31 Mar 2026 | 2 articles | Viewed by 2008 | Submission Open
Keywords: thyroid cancer treatment; tumor microenvironment; immunotherapy; targeted therapy; precision medicine
(This special issue belongs to the Section Cancer Biology and Oncology)
Skin Diseases and Cell Therapy
edited by Nives Pondeljak, Maryam Heidari Kharaji and Mirna Šitum
submission deadline 31 Mar 2026 | 2 articles | Viewed by 2007 | Submission Open
Keywords: dermatology; psoriasis; atopic dermatitis; vitiligo; alopecia; cutaneous leishmaniasis; and skin fibrosis; skin cancers; innovative therapeutic strategies; molecular mechanisms
(This special issue belongs to the Section Gene and Cell Therapy)
Advances in Immune Cell Biology: Insights from Molecular Perspectives
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1897 | Submission Open
Keywords: immune cell biology; cell signaling cascades; autoimmune disorders; immunoinflammatory pathways; hematological disorders
(This special issue belongs to the Section Cell Biology and Pathology)
New Insights in Hypoxic Response Modulation
edited by Rafał Bartoszewski
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1791 | Submission Open
Keywords: hypoxia; oxygen homeostasis; oxidative damage; cell death; ischemic events; stroke; myocardial infarction; tumor microenvironment (TME); noncoding RNA; MicroRNAs; long noncoding RNAs; PiRNA; hypoxia-inducible factors (HIFs); targeted delivery; hypoxic cells; regulatory networks; therapeutic opportunities
(This special issue belongs to the Section Cell Biology and Pathology)
Diabetes Mellitus: Pharmacological Innovations and Related Therapeutic Benefits submission deadline 31 Mar 2026 | 2 articles | Viewed by 1601 | Submission Open
Keywords: therapy of diabetes mellitus; pharmacological innovations; incretins; GLP-1 receptor agonists; SGLT-2 inhibitors; weight control; diabetes-related cardiovascular risk; non-glycemic benefits of diabetes drugs; diabetes-related technologies; diabetes outcomes
(This special issue belongs to the Section Molecular and Translational Medicine)
Microbial Metabolites and Their Impact on Gut Homeostasis submission deadline 31 Mar 2026 | 1 articles | Viewed by 1560 | Submission Open
Keywords: intestinal microbiota; microbial metabolites; gut homeostasis; inflammatory response; intestinal epithelial barrier; immune response; diet
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Biomarkers and Therapeutic Targets in Gastric Cancer: From Basic Research to Clinical Applications submission deadline 31 Mar 2026 | 1 articles | Viewed by 1478 | Submission Open
Keywords: gastric cancer; tumor microenvironment; gastric cancer metastasis; cancer stem cells; diagnosis and treatment; biomarkers
(This special issue belongs to the Section Cancer Biology and Oncology)
Brain Imaging and Cognitive Deficits in Psychiatric Disorders, 2nd Edition
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1396 | Submission Open
Keywords: cognitive deficits; psychiatric disorders; schizophrenia; brain imaging
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Emerging Insights in Thoracic Diseases: From Diagnostics to Biomarkers and Therapeutic Implications Through Interdisciplinarity submission deadline 31 Mar 2026 | 2 articles | Viewed by 1394 | Submission Open
Keywords: chronic obstructive pulmonary disease; acute respiratory diseases; cardionephrology; interstitial lung disease; interventional cardiology; pulmonary fibrosis; tuberculosis; research methodology; biomarkers; therapeutics; artificial intelligence
(This special issue belongs to the Section Molecular and Translational Medicine)
Pathogenesis and Treatment of Ophthalmic Diseases
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1376 | Submission Open
Keywords: ophthalmology; AI; ocular; eye diseases; retina; cornea; glaucoma; neuro-ophthalmology
(This special issue belongs to the Section Molecular and Translational Medicine)
Drug-Resistant Bacterial Infections and Alternative Therapies—2nd Edition
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1321 | Submission Open
Keywords: alternative agents; antibiotics; phages; endolysins; phytochemicals; drug discovery; nanoparticles; biofilms
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Imaging Technology for Human Diseases
edited by Emanuele David
submission deadline 31 Mar 2026 | 2 articles | Viewed by 1131 | Submission Open
Keywords: technological advances; imaging; X-ray; mammography; CT; MRI; ultrasound; angiography
(This special issue belongs to the Section Biomedical Engineering and Materials)
Central Role of Mitochondrial Oxidative Stress in the Pathophysiology of Disorders (2nd Edition)
edited by and André Quincozes-Santos
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1086 | Submission Open
Keywords: mitochondrial dysfunction; reactive oxygen species; bioenergetics; mitochondrial quality control; pathologies; protective agents
(This special issue belongs to the Section Molecular and Translational Medicine)
Stem Cell Therapy: Traps and Tricks
edited by and Željka Večerić-Haler
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1045 | Submission Open
Keywords: mesenchymal stem cells; MSC therapy; preclinical research; regenerative medicine
(This special issue belongs to the Section Biomedical Engineering and Materials)
Noncoding RNAs (ncRNAs): The Role in Gene Regulation and Human Diseases
edited by and
submission deadline 31 Mar 2026 | Viewed by 828 | Submission Open
Keywords: ncRNAs; genomic editing; epigenetics; stem cell biology and regenerative medicine
(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)
Feature Reviews in Target Identification and Drug Discovery
edited by
submission deadline 31 Mar 2026 | Viewed by 540 | Submission Open
Keywords: drug discovery; biological target; bioactive compounds; pharmacology
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Recent Advances in Endocrine Disease and Atherosclerosis submission deadline 31 Mar 2026 | Viewed by 450 | Submission Open
Keywords: diabetes; dyslipidemia; obesity; insulin resistance; subclinical atherosclerosis; atherosclerosis; cardiovascular disease
(This special issue belongs to the Section Endocrinology and Metabolism Research)
New Trends in Regional Anesthesia and Pain Management
edited by
submission deadline 31 Mar 2026 | Viewed by 442 | Submission Open
Keywords: regional anesthesia; ultrasound-guided/stimulator-guided nerve blocks; novel techniques for motor-sparing neural intervention; continuous catheter infusions; opioid-sparing techniques; perioperative pain management; novel local anesthetics; cadaveric dissection exploring the anatomical knowledge of motor-sparing techniques; modalities (techniques; technologies; or drug regimen) to prolong the effect of local anesthetics; ERAS-related studies; AI applications in regional anesthesia and pain management; innovations and protocols/curriculum regarding regional anesthesia and pain management in the battlefield; studies comparing new technologies/simulation (such as EpiFaith; SPRint PNS system; or CompuFlo) with traditional methods in improving regional anesthesia and pain management; regenerative medicine; nutritional pain medicine; application of bone marrow aspirate concentration or other stem cell components in pain medicine; multidisciplinary/comprehensive care program; transarterial embolization for pain management; joint denervation for pain management
(This special issue belongs to the Section Molecular and Translational Medicine)
Advanced Research in Antiviral Innate Immunity
edited by Junji Zhu
submission deadline 31 Mar 2026 | Viewed by 373 | Submission Open
Keywords: antiviral immunity; innate immune signaling; toll-like receptors (TLRs); RIG-I-like receptors (RLRs); cGAS-STING pathway; type I interferon; viral infection; post-translational modification (PTM); phase separation; host– pathogen interactions; therapeutic strategies
(This special issue belongs to the Section Microbiology in Human Health and Disease)
Roles of Extracellular Vesicles in Cancer Immunotherapy
edited by Shujing Liu and Zhiyuan Qin
submission deadline 31 Mar 2026 | Viewed by 305 | Submission Open
Keywords: extracellular vesicles; microvesicles; exosomes; cancer biology; cancer immunity; cancer immunotherapy; biomarkers; cancer vaccines; antigen presentation; drug delivery
(This special issue belongs to the Section Cancer Biology and Oncology)
Genetic Insights and Pharmacogenomic Approaches in Cancer Treatment submission deadline 31 Mar 2026 | 1 articles | Viewed by 241 | Submission Open
Keywords: pharmacogenetics; genetic basis; cancer treatments
(This special issue belongs to the Section Cancer Biology and Oncology)
Head and Neck Cancer: From Mechanisms to Therapeutic Approaches—Advances and Challenges submission deadline 31 Mar 2026 | Viewed by 214 | Submission Open
Keywords: head and neck cancers; target therapy; biomarkers; molecular targets; translational research; pathogenesis; prognosis; diagnostic tool
(This special issue belongs to the Section Cancer Biology and Oncology)
Obesity and Obesity-Related Pathology
edited by
submission deadline 31 Mar 2026 | Viewed by 208 | Submission Open
Keywords: obesity; obesity-related cardiovascular diseases; obesity-related chronic kidney diseases; diabetes mellitus; depression; obesity-related cancer; adipose tissue; adipocytes; cancer-associated adipocytes; obesity therapies
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Advances in Oral Squamous Cell Carcinoma Research
edited by Sangang Wu
submission deadline 31 Mar 2026 | Viewed by 208 | Submission Open
Keywords: oral squamous cell carcinoma; diagnostic biomarkers; therapeutic strategies; tumor microenvironment; radiotherapy; single-cell sequencing; artificial intelligence in oncology; personalized medicine; molecular mechanism; recurrence and metastasis
(This special issue belongs to the Section Cancer Biology and Oncology)
Neural Plasticity: Mechanisms and Therapeutic Implications
edited by Linlin Sun
submission deadline 31 Mar 2026 | Viewed by 201 | Submission Open
Keywords: neural plasticity; synaptic plasticity; neurogenesis; neural regeneration; brain injury; non-invasive brain stimulation techniques
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Epigenetics in the Perioperative Setting
edited by Rump Katharina
submission deadline 31 Mar 2026 | Viewed by 197 | Submission Open
Keywords: epigenetics; perioperative setting; surgical stress; anesthesia; gene expression; cognitive impairment; postoperative delirium; postoperative cognitive dysfunction (POCD); neuroinflammation; therapeutic approaches
(This special issue belongs to the Section Immunology and Immunotherapy)
Tumor Immune Microenvironment, Metabolic Remodeling and Mechanism of Cancer Metastasis
edited by and
submission deadline 31 Mar 2026 | Viewed by 193 | Submission Open
Keywords: tumor immune microenvironment; metabolic remodeling; cancer metastasis; immune– metabolic crosstalk; novel therapeutic targets for metastasis
(This special issue belongs to the Section Cancer Biology and Oncology)
Advances in Head and Neck Cancer: Mechanisms, Diagnosis, and Therapeutic Progress
edited by and Hideto Saijo
submission deadline 31 Mar 2026 | Viewed by 189 | Submission Open
Keywords: head and neck cancer; oral cancer; laryngeal cancer; nasopharyngeal cancer; thyroid cancer; diagnostic and treatment strategies
(This special issue belongs to the Section Cancer Biology and Oncology)
Lymphomas: From Mechanisms to Therapeutic Approaches
edited by Delfa Radić-Krišto and
submission deadline 31 Mar 2026 | Viewed by 188 | Submission Open
Keywords: aggressive lymphomas; cellular therapy; cellular immunotherapy; translational medicine; lymphomagenesis; indolent lymphomas; phase I/II clinical trials; targeted therapy; biomarkers; in vitro and in vivo models of lymphomas
(This special issue belongs to the Section Cancer Biology and Oncology)
Epigenetics and Immune Perspectives in Cancer: Overcoming Therapy Resistance
edited by
submission deadline 31 Mar 2026 | Viewed by 174 | Submission Open
Keywords: epigenetics; immunotherapy; therapy resistance; tumor microenvironment; DNA methylation; histone modifications; dietary intervention; non-coding RNAs; immune evasion; combination therapy
(This special issue belongs to the Section Cancer Biology and Oncology)
New Advances in the Pathology, Diagnosis and Treatment of Thyroid Tumors submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open
Keywords: goitre; thyroid cancer; screening; bias; paraneoplastic syndrome  ; immunosurveillance  ; thyroiditis  ; thyroidectomy  ; immunotherapy
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Recent Advances in Molecular Neuroimaging
edited by
submission deadline 31 Mar 2026 | Viewed by 166 | Submission Open
Keywords: molecular neuroimaging; imaging techniques; clinical applications; imaging probes; personalized medicine; diagnostic imaging; therapeutic monitoring; clinical decision support
(This special issue belongs to the Section Molecular and Translational Medicine)
Advances in Skin Diseases
edited by Nazia M. Saiyed and
submission deadline 31 Mar 2026 | Viewed by 122 | Submission Open
Keywords: skin diseases; dermatology; diagnostic innovations; targeted therapies; molecular mechanisms; immunodermatology; translational research; inflammatory skin disorders; clinical dermatology; precision medicine
(This special issue belongs to the Section Molecular and Translational Medicine)
Stem Cell Biology and Tissue Engineering for Cardiology
edited by Otilia Țica
submission deadline 31 Mar 2026 | Viewed by 118 | Submission Open
Keywords: cardiac regeneration; stem cell therapy; cardiac tissue engineering; mesenchymal stem cells (MSCs); induced pluripotent stem cells (iPSCs); cardiomyocyte differentiation; myocardial repair; 3D bioprinting; biomaterials in cardiology; cardiac scaffolds; heart organoids; translational regenerative medicine; cell-based therapy; cardiovascular bioengineering; immunomodulation in cardiac repair
(This special issue belongs to the Section Molecular and Translational Medicine)
New Approaches to Spinal Cord-Related Diseases
edited by Corentin Dauleac
submission deadline 31 Mar 2026 | Viewed by 103 | Submission Open
Keywords: spinal cord; spinal cord injury; stem cell; neuromodulation; rehabilitation; plasticity; spasticity; pain; neuroimaging
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Oxidative Stress, Mitochondrial Dysfunction, and Aβ Pathology: Converging Pathways in Aging and Neurodegeneration
edited by , Laxmi Rathor and
submission deadline 31 Mar 2026 | Viewed by 102 | Submission Open
Keywords: oxidative stress; aging; amyloid beta; tau phosphorylation; neurodegeneration; regulated cell death; mitochondrial biogenesis; Drosophila; C. elegans
(This special issue belongs to the Section Cell Biology and Pathology)
Imaging and Modeling Alzheimer's Disease: The Quest for Mechanistic Understanding, Early Diagnosis, and Novel Treatments
edited by Guoshi Li
submission deadline 31 Mar 2026 | Viewed by 99 | Submission Open
Keywords: biomarker identification; connectome analysis; computational neuroimaging; biophysical modeling; network models; machine learning; brain stimulation; neurodegeneration
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Decoding Neurodegeneration: Insights From Multi-Omics and Neuroimaging Integration
edited by
submission deadline 31 Mar 2026 | Viewed by 98 | Submission Open
Keywords: neurodegenerative; neuroimaging; executive functions; electrophysiology; brain connectivity; multi omics data; bio-molecular data; biomarkers; systems biology; single-cell omics; translational neuroscience
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Zebrafish Models: From Basic Research to Translational Medicine
edited by and Vishal Arora
submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open
Keywords: zebrafish; animal models; in vivo whole model organism imaging; epigenetics; physiological and functional discoveries; genetic engineered transgenic cellular and mutant phenotype; developmental biology; drug discovery; high-throughput drug screening; pharmacogenomics; translational research; toxicology; genomics; cardiology; cardio-oncology; cardiovascular diseases; cardio-oncology; cancer models; melanoma; tumor microenvironment; dermatology; ophthalmology; neuroscience; aging; neurodegenerative disease; diabetes; kidney disease; hematology
(This special issue belongs to the Section Molecular and Translational Medicine)
Emerging Trends in Liver Diseases and Cirrhosis Research submission deadline 31 Mar 2026 | Viewed by 94 | Submission Open
Keywords: pathogenesis of liver fibrosis and cirrhosis; MASLD; hepatitis B; C and D; primary biliary cholangitis (PBC): immunopathology and treatment advances; alcohol-associated liver disease; liver regeneration and stem-cell-based therapies; biomarkers for early diagnosis and prognosis; emerging antifibrotic treatments; liver complications and systemic comorbidities; personalized medicine in liver disease
(This special issue belongs to the Section Molecular and Translational Medicine)
Drug Discovery, Development and Delivery: Current Status and Future Perspectives submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open
Keywords: drug discovery; rational drug design; computer-aided drug design (CADD); drug repurposing; artificial intelligence (AI) and machine learning (ML); cancer therapeutics; infectious diseases; natural products
(This special issue belongs to the Section Drug Discovery, Development and Delivery)
Advances in Cardiac Remodeling
edited by Silvio Assis de Oliveira-Junior and André Soares Leopoldo
submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open
Keywords: cardiac remodeling; cardiomyocyte contractile; obesity; diabetes; diets; training; rats; humans
(This special issue belongs to the Section Molecular and Translational Medicine)
Fibromyalgia and Neuroinflammation: Unraveling Pathophysiological Links and Therapeutic Targets
edited by Mario García-Domínguez
submission deadline 31 Mar 2026 | Viewed by 83 | Submission Open
Keywords: fibromyalgia; neuroinflammation; central sensitization; glial activation; cytokines; pain modulation; chronic pain; neuroimmune interaction
(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)
Inflammatory Mechanisms, Biomarkers and Treatment in Oral Diseases submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open
Keywords: periodontal diseases; peri-implantitis; oral lichen planus; oral microbial dysbiosis; inflammatory pathways; biomarkers
(This special issue belongs to the Section Molecular and Translational Medicine)
Type 2 Diabetes: Current Progress and Future Challenges
edited by
submission deadline 31 Mar 2026 | Viewed by 75 | Submission Open
Keywords: type 2 diabetes; cardiovascular risk; novel antidiabetics; clinical guidelines therapeutic inertia; obesity; insulin resistance; metabolic syndrome; diabetology; family medicine
(This special issue belongs to the Section Endocrinology and Metabolism Research)
Sepsis and Systemic Inflammation: Mechanisms and Therapeutic Innovations
edited by
submission deadline 31 Mar 2026 | Viewed by 66 | Submission Open
Keywords: sepsis; systemic inflammation; microcirculation; intravital imaging; immune dysregulation; septic shock; therapeutic innovations
(This special issue belongs to the Section Immunology and Immunotherapy)
New Insights in Thyroid Cancer
edited by
submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open
Keywords: thyroid carcinoma; molecular diagnostics; targeted therapy; genetic mutations; radioiodine therapy; radiofrequency ablation therapy; active surveillance; precision oncology
(This special issue belongs to the Section Molecular and Translational Medicine)
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