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Biomedicines publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Mechanism of Mesenchymal Stromal Cells and Their Derivatives in Regenerative Medicine

edited by Jia Xian Law and

Kok Lun Pang

submission deadline 31 Dec 2025 | Viewed by 26 | Submission Open

Keywords: mesenchymal stromal cell; regenerative medicine; stem cell; extracellular vesicle; mechanism of action; paracrine factor; secretome; tissue engineering

(This special issue belongs to the Section Biomedical Engineering and Materials)

Pharmacogenomics and Drug Metabolism: From Cytochrome P450 to Emerging Enzymatic Pathways

edited by

Pradeepraj Durairaj

submission deadline 31 Dec 2025 | Viewed by 22 | Submission Open

Keywords: cytochrome P450 (CYP450); drug metabolism; xenobiotic metabolism; pharmacogenomics; biotransformation; orphan enzymes; redox biology; enzyme engineering; multi-omics approaches; personalized medicine

(This special issue belongs to the Section Molecular Genetics and Genetic Diseases)

Breast Cancer Research: Charting Future Directions

edited by

Mohamad Adam Bujang

submission deadline 31 Dec 2025 | Viewed by 19 | Submission Open

Keywords: personalized medicine; biomarkers for early detection; immunotherapy; patient-reported outcomes

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Chondrocyte Biology (2nd Edition)

edited by

Bo Qiu

submission deadline 31 Dec 2025 | Viewed by 17 | Submission Open

Keywords: osteoarthritis; chondrocyte; differentiation; proliferation; signaling pathways; transcription factor; inflammation; cellular processes; cartilage repair

(This special issue belongs to the Section Cell Biology and Pathology)

Genetic Research on Colorectal Cancers

edited by

Wangxiong Hu

submission deadline 31 Dec 2025 | Viewed by 17 | Submission Open

Keywords: high microsatellite instability; epigenetic age acceleration; spatial omics and single-cell sequencing; cold tumors and immunotherapy; driver gene; DNA replication repair; liquid biopsy; ctDNA

(This special issue belongs to the Section Cancer Biology and Oncology)

HIV Therapy: The Latest Developments in Antiviral Drugs

edited by

Francisco Javier Fanjul Losa

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: HIV; antiviral drugs; experimental therapeutics; drug discovery; viral reservoirs; mechanism of action; preclinical models; novel HIV targets; antiretroviral therapy (ART); immunotherapy (experimental aspects)

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Epigenetics in Human Cancer: Emerging Biomarkers and Therapeutic Targets

edited by

Jeong-yeon Lee

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: cancer; epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs; therapeutic resistance

(This special issue belongs to the Section Cancer Biology and Oncology)

The Role of Telomere and Telomerase in Human Disease-2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2025 | Viewed by 15 | Submission Open

Keywords: telomere; telomerase; cancer; aging

(This special issue belongs to the Section Molecular and Translational Medicine)

Oxidative Stress in Health and Disease

edited by Federica Mannino

submission deadline 31 Dec 2025 | Viewed by 14 | Submission Open

Keywords: oxidative stress; inflammation; human diseases; apoptosis; peroxidation; DNA damage; mitochondria

(This special issue belongs to the Section Cell Biology and Pathology)

Mitochondrial Function as a Target in Nanomedicine

edited by

Agnieszka Pyrczak-Felczykowska

submission deadline 31 Dec 2025 | Viewed by 13 | Submission Open

Keywords: nanomedicine; nanoparticles; drug delivery; mitochondria; cancer; neurodegenerative disease; metabolism; targeted therapy; mitochondrial function; bioactive compounds.

(This special issue belongs to the Section Nanomedicine and Nanobiology)

Dopamine and Androgen Receptor Signaling: Novel Insights in Cancer Biology

edited by Srijan Acharya

submission deadline 31 Dec 2025 | Viewed by 13 | Submission Open

Keywords: dopamine signaling; androgen receptor; cancer biology; hormone-sensitive tumors; signal transduction; tumor microenvironment; neurotransmitters in cancer; prostate cancer; breast cancer; targeted therapy

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Precision Oncology for Thyroid Carcinoma: Integrating Artificial Intelligence, Genomics and Molecular Diagnostics

edited by

Kyoung Sik Park

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: thyroid carcinoma; artificial intelligence; genomics; precision oncology; molecular diagnostics

(This special issue belongs to the Section Cancer Biology and Oncology)

Oral Squamous Cell Carcinoma: Molecular Signaling Pathways and Novel Biomarkers—2nd Edition

edited by

Sadhna Aggarwal

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: oral squamous cell carcinoma (OSCC); molecular signaling pathways; biomarkers; pathogenesis; targeted therap; tumor growth; tumor invasion; angiogenesis; tumor metastasis; immune response modulation

(This special issue belongs to the Section Cancer Biology and Oncology)

Glomerular Disease and Cystic Kidney Disease: From Pathogenesis to Novel Therapeutic Approaches—2nd Edition

edited by Vassilis Filiopoulos and

Chrysanthi Skalioti

submission deadline 31 Dec 2025 | Viewed by 12 | Submission Open

Keywords: glomerular disease; glomerulonephritis; glomerulopathy; podocytopathies; ciliopathies; cystic kidney disease; polycystic kidney disease; tolvaptan; vasopressin

(This special issue belongs to the Section Molecular and Translational Medicine)

Animal Models for the Study of Cardiovascular Physiology—Second Edition

edited by Sandra Lia Amaral

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: hypertension; stroke; myocardium infarction; arterial stiffness; supravalvular aortic stenosis; cardiac remodeling; capillary angiogenesis; exercise training; vascular diseases; non-pharmacological treatment

(This special issue belongs to the Section Cell Biology and Pathology)

Pathomechanisms of Disturbances Underlying Chronic Disorders—Third Edition

edited by

Dorota Formanowicz

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: chronic disorders; atherosclerosis; inflammation; oxidative stress; lipoproteins; endothelial dysfunction; biomarkers; pathomechanisms

(This special issue belongs to the Section Immunology and Immunotherapy)

Recent Advances in Gastrointestinal Cancers: From Microbiota Modulation to New Therapeutic Approaches—2nd Edition

edited by

Serena Martinelli

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: gastrointestinal cancers; microbiota; anticancer therapy; immunotherapy; precision medicine

(This special issue belongs to the Section Cancer Biology and Oncology)

Advances in Wound Healing

edited by

Qi Zhang

and

Yiwei Qi

submission deadline 31 Dec 2025 | Viewed by 11 | Submission Open

Keywords: wound healing; scar and keloid; diabetic ulcers; multi-omics analysis for wound healing; biomaterials for wound healing; tissue engineering for wound healing; wound infection management; clinical trials and cases of wound healing

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in Heart–Brain Axis

edited by Teresa Soda

submission deadline 31 Dec 2025 | Viewed by 9 | Submission Open

Keywords: heart– brain axis; neurocardiology; autonomic nervous system; neuroinflammation; cardiac– cerebral syndromes; psychocardiology; calcium signaling; synaptic plasticity; ion transport; translational neuroscience

(This special issue belongs to the Section Molecular and Translational Medicine)

Novel Drug Delivery Systems: Design, Evaluation and Application: 2nd Edition

edited by

Yongtai Zhang

submission deadline 31 Dec 2025 | Viewed by 5 | Submission Open

Keywords: pharmaceutics; drug delivery systems; nanoparticles; nanomedicine; biomolecules; hydrogels; biomaterials

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

New Insights in Reproductive Health and Disease

edited by

Chi Chiu Wang

submission deadline 31 Dec 2025 | Viewed by 2 | Submission Open

Keywords: reproductive health; artificial intelligence; fertility preservation; stem cells; gene therapy; materials; meiosis; DNA double-strand break; ovarian dysfunction; nanomedicine; pregnancy complications

(This special issue belongs to the Section Molecular and Translational Medicine)

Inflammation in Neurogenerative Diseases: Mechanisms and Therapeutic Frontiers

edited by

Shao-Bin Wang

submission deadline 1 Jan 2026 | Viewed by 19 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; biomarkers mitochondria dysfunction; microglia; immune response; therapeutic development; gene therapy

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Nanoparticles for Glioblastoma Therapy

edited by Shambhavi Pandey and

Benjamí Oller-Salvia

submission deadline 20 Jan 2026 | Viewed by 12 | Submission Open

Keywords: nanoparticles; blood& ndash; brain barrier; gene delivery; glioblastoma; cancer stem cells; biomaterials

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Infectious Diseases: Prevention, Diagnosis, and Treatment Under Antimicrobial Resistance Global Urgency

edited by

Célia F. Rodrigues

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1169 | Submission Open

Keywords: AMR; infectious diseases; bacteria; fungi; alternative treatment

(This special issue belongs to the Section Microbiology in Human Health and Disease)

Advancements in Cardiac Imaging: Diagnostics, Prognostics, and Therapeutics

edited by Ilaria Dentamaro

submission deadline 31 Jan 2026 | 1 articles | Viewed by 645 | Submission Open

Keywords: cardiac imaging; echocardiography; cardiovascular magnetic resonance imaging; cardio CT; nuclear cardiology

(This special issue belongs to the Section Molecular and Translational Medicine)

Advancements and Challenges in Anticancer Targeted Therapy with Small Molecules

edited by Monika Papiez

submission deadline 31 Jan 2026 | Viewed by 240 | Submission Open

Keywords: small molecules; cancer; anticancer targeted therapy; cancer resistance; cancer growth blockers

(This special issue belongs to the Section Cancer Biology and Oncology)

New Advances in Epilepsy Research

edited by Duyu A. Nie

submission deadline 31 Jan 2026 | Viewed by 206 | Submission Open

Keywords: disease mechanisms; genetics; biomarkers; epilepsy surgery; electroencephalogram; animal models; artificial intelligence

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Parkinson’s Disease: Where Are We and Where Are We Going To

edited by Carmen Borrué

submission deadline 31 Jan 2026 | Viewed by 155 | Submission Open

Keywords: Parkinson’ s disease; gait disorders; biomarkers; neurodegenerative disease; AI

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Advances in Cardiovascular Diseases: Pathophysiological Insights, Therapeutic Strategies and Future Directions

edited by

Azizah Ugusman

, Wan Amir Nizam Wan Ahmad and Dharmani Devi Murugan

submission deadline 31 Jan 2026 | Viewed by 56 | Submission Open

Keywords: cardiovascular disease; pathophysiology; therapeutic strategies; translational research; complementary medicine

(This special issue belongs to the Section Molecular and Translational Medicine)

Antibody Responses to Viral Infections: Insights from Structural Biology

edited by Pragati Agnihotri and

Sharanbasappa Karade

submission deadline 31 Jan 2026 | Viewed by 29 | Submission Open

Keywords: crystal structure; virus– antibody complexes; broadly neutralizing antibodies; immunology; epitope mapping

(This special issue belongs to the Section Microbiology in Human Health and Disease)

New Advances in Biomaterials for Tissue Repair and Regeneration

edited by Fei Xing, Wen Nie and Zhao Chen

submission deadline 31 Jan 2026 | Viewed by 25 | Submission Open

Keywords: biomaterials; nanomaterials; tissue repair; 3D printing; functionals biomaterials; biomaterial science; tissue regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Nervous System Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by Natalia Rozas and Cameron Jeter

submission deadline 31 Jan 2026 | Viewed by 25 | Submission Open

Keywords: neurodegenerative diseases; neuromuscular diseases; autoimmune diseases of the nervous system; brain diseases; neuroinflammatory diseases; neuromuscular diseases; trauma of the nervous system

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Metabolic Disorders and Their Complications: From Molecular Mechanisms to Therapeutic Perspectives

edited by

Sandeep Kumar

Abhishek Gupta

and

Atul Kumar Pandey

submission deadline 31 Jan 2026 | Viewed by 21 | Submission Open

Keywords: metabolism; diabetes; obesity; nutrition; AMPK and mTOR

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Additive Manufacturing in Biomedical Applications

edited by

Paweł Turek

submission deadline 31 Jan 2026 | Viewed by 18 | Submission Open

Keywords: additive manufacturing; scaffolds; implant; anatomical models; in vivo; in vitro; surface texture; geometrical accuracy; biomaterials; surface roughness

(This special issue belongs to the Section Biomedical Engineering and Materials)

Gut Microbiota, Diet, and Immunity: Investigating the Connections and Implications for Disease Development—3rd Edition

edited by

Farhad Vahid

submission deadline 31 Jan 2026 | Viewed by 15 | Submission Open

Keywords: gut microbiota; diet; immunity; microbiome; dysbiosis; inflammatory bowel diseases; cancer; CVD; T2D; obesity; overweight; autoimmune diseases; metabolic syndromes; immunomodulation; microbial diversity; nutrient– gut microbiota interactions; probiotics; prebiotics; immune system development; disease susceptibility; therapeutic interventions; host– microbe interactions; gut– brain axis; microbial metabolites; precision nutrition

(This special issue belongs to the Section Molecular and Translational Medicine)

New Advances in Human Reproductive Biology

edited by

Nikolaos Machairiotis

submission deadline 31 Jan 2026 | Viewed by 14 | Submission Open

Keywords: gametogenesis; fertilization; egg retrieval; embryo implantation; epigenetics; microRNAs in fertility; hormonal signaling; stem cells and fertility; assisted reproductive technologies; molecular and polymorphism in fertility; reproductive health novelty

(This special issue belongs to the Section Molecular and Translational Medicine)

Urothelial Carcinoma: Role of Biomarkers in Diagnosis, Prognosis and Treatment (2nd Edition)

edited by Ioannis Zachos and

Panagiotis Vlachostergios

submission deadline 31 Jan 2026 | Viewed by 13 | Submission Open

Keywords: urothelial carcinoma; biomarker; diagnosis; treatment; prognosis

(This special issue belongs to the Section Molecular and Translational Medicine)

Pharmacogenetics and Pharmacogenomics: Driving Forces in Modern Precision Medicine

edited by Miriam Saiz-Rodríguez and Dora Koller

submission deadline 31 Jan 2026 | Viewed by 12 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; precision medicine; polygenic risk scores; phenoconversion; drug response; genetic biomarkers; personalized therapy; underrepresented populations; clinical implementation

(This special issue belongs to the Section Drug Discovery, Development and Delivery)

Pharmacological Mechanisms and Target Discovery in Lung Injury-Driven Fibrosis: From Molecular Pathways to Preclinical Innovation

edited by

Huifang Tang

submission deadline 31 Jan 2026 | Viewed by 12 | Submission Open

Keywords: lung injury and fibrosis; pharmacological mechanisms; target discovery; mechanistic drivers; target identification; drug design; preclinical models

(This special issue belongs to the Section Molecular and Translational Medicine)

Pathogenesis, Diagnostics and Therapeutics in Obsterics and Gynaecology (2nd Edition)

edited by

Nikolaos Machairiotis

submission deadline 31 Jan 2026 | Viewed by 11 | Submission Open

Keywords: gynaecology; obstetrics; diagnosis; pathogenesis; treatment

(This special issue belongs to the Section Molecular and Translational Medicine)

Advances in 3D Printing for Drug Delivery Systems

edited by

Ion-Bogdan Dumitrescu

, Cristina Manuela Drăgoi and Alina Crenguța Nicolae

submission deadline 31 Jan 2026 | Viewed by 10 | Submission Open

Keywords: 3D printing; drug delivery systems; personalized medicine; pharmaceutical engineering; controlled release

(This special issue belongs to the Section Biomedical Engineering and Materials)

Advances in Allergies and Autoimmunity

edited by

Mukesh Verma

submission deadline 31 Jan 2026 | Viewed by 9 | Submission Open

Keywords: asthma; arthritis; diabetes; inflammatory bowel disease; dermatomyositis; Sjö gren's syndrome; systemic lupus erythematosus; psoriasis; multiple sclerosis

(This special issue belongs to the Section Cell Biology and Pathology)

Molecular Signatures and Therapeutic Strategies in Urological Cancers

edited by Haoyue Sheng

submission deadline 31 Jan 2026 | Viewed by 6 | Submission Open

Keywords: urological cancers; molecular signatures; precision medicine; non-coding RNAs; tumor microenvironment

(This special issue belongs to the Section Molecular and Translational Medicine)

Innovations in Bone and Craniofacial Tissue Engineering: From Biomaterials and Mechanobiology to Clinical Applications

edited by Zhekai Hu

submission deadline 15 Feb 2026 | Viewed by 18 | Submission Open

Keywords: bone tissue engineering; craniofacial regeneration; biomaterials and scaffolds; stem cells and exosomes; mechanobiology and orthodontic forces; osteoimmunology; oxidative stress modulation; gene/drug delivery; translational research; periodontal and alveolar bone regeneration

(This special issue belongs to the Section Biomedical Engineering and Materials)

Cellular and Pathogenesis Mechanisms in Oral Cancer

edited by

Jun-Ichi Tanuma

submission deadline 28 Feb 2026 | 4 articles | Viewed by 10667 | Submission Open

Keywords: oral carcinogenesis; oral cancer model; OSCC; oral cytology; biomarkers; targeted therapies; precision medicine; bioinformatics

(This special issue belongs to the Section Molecular and Translational Medicine)

Glioblastoma: Pathogenetic, Diagnostic and Therapeutic Perspectives

edited by

Thi Thu Trang Nguyen

submission deadline 28 Feb 2026 | 5 articles | Viewed by 9095 | Submission Open

Keywords: drug delivery methods (TTFields; nanoparticles); immunotherapy; oncolytic virotherapy; cell metabolism (glycolysis; OXPHOS; fatty acid oxidation); epigenetic; biomarkers; gene therapy (CRISPR/Cas9)

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Endothelial Dysfunction: From a Pathophysiological Mechanism to a Potential Therapeutic Target—3rd Edition

edited by

Pasquale Ambrosino

and

Guido Grassi

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1623 | Submission Open

Keywords: endothelial function; arterial stiffness; vascular medicine; cardiovascular risk; nitric oxide; reactive oxygen species; interleukins; inflammation; biomarkers

(This special issue belongs to the Section Cell Biology and Pathology)

Multisystem Crosstalk in Health and Disease

edited by

Mehmet Bostancıklıoğlu

submission deadline 28 Feb 2026 | Viewed by 393 | Submission Open

Keywords: systems biology; immunometabolism; inflammation; integrative physiology; molecular pathways; translational research; multi-omics; chronic disease; host– microbe interactions; metabolic regulation

(This special issue belongs to the Section Endocrinology and Metabolism Research)

Multidisciplinary Approaches to Neurodegenerative Disorders

edited by Toomas Toomsoo

submission deadline 28 Feb 2026 | Viewed by 11 | Submission Open

Keywords: neurodegenerative disorders; lipid metabolism; comorbidity patterns super-agers; precision medicine; biomarker discovery; AI-assisted diagnostics; translational neuroscience; multi-omics integration; neuroinflammation

(This special issue belongs to the Section Neurobiology and Clinical Neuroscience)

Growth Hormone Disorders and Their Related Diseases: From Pathophysiology to Therapeutic Approaches

edited by

Giorgio Sodero

submission deadline 28 Feb 2026 | Viewed by 10 | Submission Open

Keywords: growth; growth hormone deficiency; GH; IGF-1; pediatric endocrinology

(This special issue belongs to the Section Endocrinology and Metabolism Research)

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