Novel Biomaterials and Tissue Engineering Approaches in Periodontal Regeneration
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Biomedical Engineering and Materials".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 56
Special Issue Editor
Interests: bone regeneration; biomaterials; dental implants; MSCs differentiation; bone substitute materials; biological interfaces
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
According to the WHO, periodontitis in its severe form affects about one tenth of adults worldwide and can be found in sixth place in the list of the most prevalent human diseases. The periodontium is a complex system composed of different tissues supporting and surrounding the tooth: the gingiva, periodontal ligament (PDL), cementum, and alveolar bone. In healthy subjects, the PDL covers the tooth root almost entirely and the tight epithelial seal prevents microorganisms from reaching the PDL, while in patients, the tissular integrity of the periodontium is severely compromised. Any regeneration approach involving such a hierarchically compartmentalized architecture will face significant challenges, and these have so far hindered the clinical translation of promising basic science discoveries. Further research endeavors are needed in order to finally attain bio-mimicking materials, effective cell-laden scaffolds, and 3D bioprinting techniques to eventually enable advanced clinical treatments that can replace the bone grafts and membranes traditionally used in guided tissue regeneration. New dental techniques hold promise in bridging the gap between research and clinical applications.
As the Guest Editor of this Special Issue of Biomedicines, I would like to invite colleagues who have experience in both the dental and biological fields and who are experts in dental tissue engineering to participate. This Special Issue will serve as a report on the state of the art in basic, translational, and clinical research in the tissue engineering field, to provide fellow dentists and researchers from various specialisms with information on regenerative techniques.
This Special Issue will cover, but will not be limited to, the following topics:
- 3D bioprinting;
- Bases of periodontal physiology;
- Regeneration aspects of periodontal therapy;
- Regeneration aspects of implantology;
- 3D models of the periodontium;
- Mesenchymal stromal/stem cells (MSCs), preferably of dental origin;
- Cell senescence in MSCs;
- Cell aging in MSCs;
- Therapeutic approaches to attenuating the senescence/aging phenotypes of MSCs;
- The state of the art of clinical applications of stem cells in bone and periodontal regeneration.
It is my pleasure to invite you to submit a manuscript for consideration for this Special Issue. Full papers, communications, and reviews are welcome.
Dr. Federico Mussano
Guest Editor
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Keywords
- periodontium
- tissue engineering
- regenerative medicine
- biomaterials
- bioprinting
- mesenchymal stem/stromal cells
- senescence
- aging
- advanced therapeutics
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