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Biomedicines
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The Aging Metabolism: Diabetes, Obesity, and Lifespan Insights
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The Aging Metabolism: Diabetes, Obesity, and Lifespan Insights

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Endocrinology and Metabolism Research".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2461

Special Issue Editors

Dr. Rafael Ramírez-Carracedo

E-Mail Website
Guest Editor
Department of Surgery, Medical and Social Sciences, Area of Human Anatomy and Embryology, School of Medicine and Health Sciences, Universidad de Alcalá, Madrid, Spain
Interests: cardiometabolic diseases; nanotechnology; cell signaling
Dr. Rafael Moreno-Gómez-Toledano

E-Mail Website
Guest Editor
Department of Surgery, Medical and Social Sciences, Area of ​​Human Anatomy and Embryology, School of Medicine and Health Sciences, Universidad de Alcalá, Madrid, Spain
Interests: endocrine disruptors; renal physiology; cardiovascular system; diabetes; environmental health; epidemiology

Special Issue Information

Dear Colleagues,

Metabolic diseases, including diabetes and obesity, represent a growing global health challenge, particularly as populations age due to lower birth rates and increased life expectancy in Western society. These conditions are closely linked to age-related physiological changes and altered cell signaling pathways, making their prevention and management increasingly complex. Understanding the molecular mechanisms, genetic and epigenetic factors, and pathophysiology underlying these disorders is essential in developing innovative interventions to promote healthy aging.

This Special Issue will present cutting-edge research on metabolic and age-related diseases, focusing on diabetes and obesity and their interplay with the aging process. To align with the journal’s scope, contributions may include studies on pathogenesis and disease mechanisms, molecular and cell signaling pathways, biomarkers for early diagnosis, pharmacological therapies, redox-related mechanisms, biopharmaceutical approaches, or microbiome interventions. This Special Issue will bring together high-quality preclinical and clinical results to advance our understanding of metabolic disorders and aging, with the aim of ultimately informing new therapies or precision medicine strategies to improve the healthspan and patient outcomes.

Original research articles and reviews are welcome. Research areas may include, but are not limited to, molecular mechanisms, cell signaling, genetic and epigenetic regulation, biomarkers, pharmacological therapies, and precision medicine.

We look forward to receiving your submissions.

Dr. Rafael Ramírez-Carracedo
Dr. Rafael Moreno-Gómez-Toledano
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic diseases
  • aging
  • obesity
  • diabetes
  • cell signaling

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Published Papers (2 papers)

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Research

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13 pages, 833 KB  
Article
Age-Dependent Differences in Exercise Response Among Healthy Women: Impact on Inflammation, Lipids Profile and Glucose
by Shamma Almuraikhy, Maha Sellami, Monoem Haddad, Najeha Rizwana Anwardeen, Mariam Al-Mohannadi and Mohamed A. Elrayess
Biomedicines 2026, 14(3), 575; https://doi.org/10.3390/biomedicines14030575 - 4 Mar 2026
Viewed by 762
Abstract
Background: Inflammatory and metabolic risk factors are associated with adverse health outcomes among aging women. Physical activity may reduce these detrimental changes, helping to promote healthier aging. Methods: Seventy-nine non-obese women, aged 20–50 years, completed a supervised 4–8 week aerobic training program with [...] Read more.
Background: Inflammatory and metabolic risk factors are associated with adverse health outcomes among aging women. Physical activity may reduce these detrimental changes, helping to promote healthier aging. Methods: Seventy-nine non-obese women, aged 20–50 years, completed a supervised 4–8 week aerobic training program with measurements obtained before and after the intervention. The 20–30-year group (n = 29) completed a 4-week training program, with 13 participants fasting during training, while the 30–50-year group (n = 50) completed an 8-week program. Fasting blood sugar (FBS), lipid profile, insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA IR), body composition, multiple cytokines, oxidative stress markers and leukocyte telomere length were assessed. Mixed-effects linear models were used to test age-by-activity (before versus after) interactions, adjusting for body mass index (BMI), fasting status and training duration. Results: Physical activity was associated with a higher superoxide dismutase (SOD) activity, lower tumor necrosis factor alpha (TNF α) concentrations, increased weekly Metabolic Equivalent of Task (METs) and a modest reduction in high-density lipoprotein (HDL) cholesterol. Significant age-by-activity interactions were identified for fat-free mass, total cholesterol, HDL cholesterol, FBS and TNF α, exhibiting attenuated or reversed age-related slopes for these traits after training. Specifically, older active women exhibited less age-related increases in FBS and TNF α and greater age-related reductions in total cholesterol, whereas the preservation of fat-free mass was more pronounced among younger participants. Conclusions: A short moderate-intensity aerobic program was sufficient to improve antioxidant defenses and inflammatory status and reshape age-group-specific responses to the training of selected glycemic, lipid, inflammatory and functional markers in healthy women, partly mitigating adverse age-associated changes, particularly in older participants. By modeling age-by-activity interactions across various metabolic and inflammatory risk factors, this study provides evidence that short-term moderate aerobic training can reshape age-group-specific cardiometabolic responses to training. Full article
(This article belongs to the Special Issue The Aging Metabolism: Diabetes, Obesity, and Lifespan Insights)
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Review

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9 pages, 830 KB  
Review
RBP4 in Ageing
by María Paz Nieto-Bona, María García-De Frutos and Adriana Izquierdo-Lahuerta
Biomedicines 2026, 14(2), 463; https://doi.org/10.3390/biomedicines14020463 - 19 Feb 2026
Viewed by 1253
Abstract
Background: The protein that binds to retinol 4 (RBP4), is a lipocalin-family protein, secreted primarily by the adipose tissue and the liver, and has also been reported to be produced by other tissues, including the kidney. This protein mediates the transport of vitamin [...] Read more.
Background: The protein that binds to retinol 4 (RBP4), is a lipocalin-family protein, secreted primarily by the adipose tissue and the liver, and has also been reported to be produced by other tissues, including the kidney. This protein mediates the transport of vitamin A (retinol) in the circulation, bound to a transporter protein, transthyretin. In recent years, RBP4 has been shown to contribute to the development of insulin resistance and a range of metabolic disorders such as type 2 diabetes mellitus, gestational diabetes, obesity, metabolic syndrome, hyperuricaemia, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiorenal diseases. Objectives: The objective was to analyse the role of RBP4 in ageing, as well as its mechanisms and effects across organs and systems. Results: Circulating RBP4 levels increase with age and have been related to the onset of various processes like sarcopenia, elevated neurodegenerative markers in the brain, and an increase in TSH levels. Furthermore, it appears that in ageing, the rise in RBP4 is related to the development of atherogenesis, chronic kidney disease, and osteoarthritis. These effects appear to be mediated by chronic inflammation along with the development of insulin resistance, increased oxidative stress and mitochondrial dysfunction, inhibition of autophagy, and intestinal dysbiosis. Conclusions: RBP4 is a factor to be taken into account in the ageing process, as it has been shown that elevated circulating serum levels in older individuals lead to and accelerate deterioration across different organs or systems. Full article
(This article belongs to the Special Issue The Aging Metabolism: Diabetes, Obesity, and Lifespan Insights)
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