Novel Insights into Depression Research: Neurobiology, Models, Biomarkers and Therapies

Dear Colleagues,

Depression remains the leading cause of disability worldwide, yet its pathophysiology is still incompletely understood, hampering its diagnosis and therapeutic success. This Special Issue, “Novel Insights into Depression Research: Neurobiology, Models, Biomarkers and Therapies,” highlights breakthroughs that are rapidly redefining this field. We welcome original articles and authoritative reviews that elucidate novel synaptic, immune or gut–brain mechanisms; validate next-generation animal, organoid or in silico models; and identify robust genomic, proteomic or digital biomarkers capable of predicting depression onset, trajectory or treatment response. Contributions showcasing rapid-acting antidepressants and innovative neuromodulation protocols are also welcome, as they further bridge mechanistic insights and clinical practice.

We invite researchers to contribute high-quality original research and review articles to this Special Issue that advance our understanding of depression and shape the future of more effective, personalized treatments. We hope that this Special Issue will provide a platform to inform new breakthroughs in this field.

Prof. Dr. Adela Magdalena Ciobanu
Guest Editor

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