Genitourinary Cancers: From Molecular Pathogenesis to Precision Diagnosis and Therapy

A Special Issue of Biomedicines (ISSN 2227-9059) belonging to the section "Cancer Biology and Oncology".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 1278

Editors


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Guest Editor
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Interests: prostate cancer; bladder cancer; PROTAC; extracellular vesicles; oncolytic virus; IRE

E-Mail
Guest Editor
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Interests: prostate cancer; extracellular vesicles; oncolytic virus; fluorescence-guided surgery

Special Issue Information

Dear Colleagues,

This Special Issue, “Genitourinary Cancers: From Molecular Pathogenesis to Precision Diagnosis and Therapy”, will mainly focus on the integration of pathophysiology, diagnostic innovation, and therapeutic advances for prostate, bladder, renal, and testicular malignancies.

Until a few years ago, the treatment of genitourinary tumors relied primarily on surgery, cytotoxic chemotherapy, and radiation. Recently, targeted therapies, immune checkpoint inhibitors, and PARP inhibitors have transformed clinical outcomes, yet drug resistance and disease recurrence remain critical challenges. Investigators have started to realize that a deeper understanding of tumor pathobiology, coupled with multi-omics and AI-driven diagnostics, is essential in developing next-generation precision therapies and overcoming therapeutic resistance.

We cordially invite authors in this field to submit original research or review articles pertaining to this important and rapidly progressing field of biomedicine.

Dr. Qi-Dong Xia
Dr. Jian-Xuan Sun
Guest Editors

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Keywords

  • genitourinary tumors
  • molecular pathogenesis
  • tumor microenvironment
  • biomarkers
  • liquid biopsy
  • immunotherapy
  • targeted therapy
  • therapy resistance
  • precision diagnosis

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Published Papers (1 paper)

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Research

17 pages, 1191 KB  
Article
Unveiling the Importance of the Expression of LY6/UPAR Gene Family Members in Urothelial Carcinoma of the Urinary Bladder
by Tuba Dilay Kökenek Ünal, Keziban Korkmaz Bayram, Aida Nurul Barokah, Buse Bayazit Gözüküçük, Umut Inan, Enes Topal and Yusuf Özkul
Biomedicines 2026, 14(6), 1339; https://doi.org/10.3390/biomedicines14061339 - 12 Jun 2026
Viewed by 905
Abstract
Background/Objectives: Urothelial carcinomas are the most common tumors of the bladder. There are limited known cancer stem cell markers in these tumors. Ly6/uPAR gene family members are considered to be markers of cancer stem cells and tissue stem cells in mice, but [...] Read more.
Background/Objectives: Urothelial carcinomas are the most common tumors of the bladder. There are limited known cancer stem cell markers in these tumors. Ly6/uPAR gene family members are considered to be markers of cancer stem cells and tissue stem cells in mice, but studies on their expression or role in human cancers are limited. In this study, we aimed to investigate the expression of LY6/uPAR gene family members in human urothelial cancers. Methods: A total of 84 patients were included in the study. Patients diagnosed with urothelial carcinoma were divided into low-grade noninvasive and high-grade invasive carcinoma groups. Normal urothelial samples were used as a control group. RNA isolation was performed from paraffin blocks, and then cDNA was obtained. LY6D, LY6E, LY6H, LY6K, PSCA, LYPD2, SLURP1, GML, GPIHBP1, and LYNX1 genes were analyzed by qRT-PCR method. Results: We observed significantly higher expression of LY6E, LY6K, PSCA, GPIHBP1, and LYNX1 genes in urothelial carcinomas, but lower expression of LY6H, LYPD2, and SLURP1 genes in urothelial cancers compared to the control tissue. Decreased expression of LY6H, PSCA, LYPD2, SLURP1, and GPIHBP1 genes was significantly correlated with poor survival. Conclusions: In the present study, the expression of this gene family in bladder cancer was investigated for the first time in the literature. Given their potential prognostic role and possible relevance as therapeutic targets, this study presents preliminary observations that add to the existing literature. Full article
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