Genomics and Epitranscriptomics Regulation in Cancer

Dear Colleagues,

Cancer pathogenesis involves not only genetic alterations but also sophisticated layers of post-transcriptional regulation that collectively dictate malignant phenotypes. The emergence of epitranscriptomics, the study of post-transcriptional RNA modifications, has unveiled a dynamic regulatory dimension in cancer biology, complementing established genomic and transcriptomic perspectives.

This Special Issue aims to compile advanced research and reviews that elucidate the roles of genomic and epitranscriptomic mechanisms in cancer development, progression, and treatment. Research areas may include (but are not limited to) the following:

• Mutations, copy number variations, and structural variations in cancer genomes;
• The role of RNA modifications in tumorigenesis, metastasis, and therapy response;
• Regulatory roles of microRNAs, long non‑coding RNAs, and circular RNAs in cancer;
• Genetic and epitranscriptomic alterations contributing to resistance against therapeutic strategies;
• Epitranscriptomic regulators as therapeutic targets.

We look forward to receiving your contributions.

Dr. Ilias Georgakopoulos-Soares
Dr. Candace S. Y. Chan
Guest Editors

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