Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lysosomes and Diseases Associated with Its Dysfunction submission deadline 15 Nov 2025 | 4 articles | Viewed by 20344 | Submission Open
Keywords: activities; mutations; endocytosis; autophagy; metabolism; proteins
(This special issue belongs to the Section Cell Biology)
Physiology and Pathophysiology of the Kidney
edited by Gang Liu
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4672 | Submission Open
Keywords: renal physiology; renal hemodynamics; kidney injury; regenerative therapies; urology
(This special issue belongs to the Section Physiology)
Regulatory Mechanisms of Plant Stress Response
edited by and Li Ren
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4666 | Submission Open
Keywords: gene; gene expression; gene function; molecular regulation; genetic resource; phenotype; stress response
(This special issue belongs to the Section Genetics and Genomics)
Germ, Sertoli and Leydig Cells in the Testis
edited by and María Fernanda Riera
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3175 | Submission Open
Keywords: Sertoli cells; Leydig cells; spermatogonia; spermatocytes; spermatozoa; stem cell niche; testis; omics analysis; environmental toxicants; non-coding RNAs  
(This special issue belongs to the Section Cell Biology)
Mitochondrial Dysfunction and Aging
edited by Huiliang Zhang
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3138 | Submission Open
Keywords: mitochondrial dysfunction; aging; cardiovascular diseases; Alzheimer’ s disease and related dementia; stem cell; skeletal muscle; kidney
(This special issue belongs to the Section Medical Biology)
Genetics and Cell Biology in Crop Improvement
edited by , , Jie Huang and Xixi Liu
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2244 | Submission Open
Keywords: plant genomics and genetics; gene cloning and function; crop molecular breeding; germplasm enhancement; genetic engineering; plant cell biology; crop adaptability
(This special issue belongs to the Section Plant Science)
Exposure to Heavy Metals: Advances in Cytotoxicity and Genotoxicity
edited by Qianru Chi and Yi Zhao
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1276 | Submission Open
Keywords: heavy metal pollutants; exposure assessment; toxic mechanism; biomarkers; metabolomics; environmental quality monitoring; bioinformatics analysis methods
(This special issue belongs to the Section Toxicology)
Diet and Environmental Stress Impacts on Farm Animal Production
edited by and Michael Chimonyo
submission deadline 30 Nov 2025 | Viewed by 934 | Submission Open
Keywords: animal production; feed types; feed preparation; feed additives; diet quality and palatability; climate variability; housing environment
(This special issue belongs to the Section Zoology)
Managing Hybridizing Populations: Threats or Opportunities for Conservation?
edited by and Marco Musiani
submission deadline 30 Nov 2025 | Viewed by 736 | Submission Open
Keywords: natural hybridization; anthropogenic hybridization; adaptive introgression; hybrid fitness; coexistence of wildlife and free-ranging domestic animals; management of hybridizing populations
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Exploring the Molecular Basis of Cancer: Perspectives from Genetics and Epigenetics
edited by
submission deadline 30 Nov 2025 | Viewed by 378 | Submission Open
Keywords: cancer genetics; epigenetics; tumor heterogeneity; histone modification; next-generation sequencing (NGS); cancer transcriptomics; gene regulation; mouse model; chromatin remodeling; CHIP-Seq; ATAC-seq; mutation; amplification
(This special issue belongs to the Section Genetics and Genomics)
Current Research in the Biodiversity, Ecology, and Evolution of Chondrichthyan Fishes (Sharks, Rays and Chimaeras)
edited by , and João Paulo Capretz Batista da Silva
submission deadline 30 Nov 2025 | Viewed by 378 | Submission Open
Keywords: Chondrichthyes; Elasmobranchii; Holocephali; sharks; skates; rays; chimaeras; chimaeras; biodiversity; taxonomy; systematics; ecology; evolution
(This special issue belongs to the Section Marine Biology)
Breast Cancer: Molecular and Cellular Mechanism and Biomarkers submission deadline 30 Nov 2025 | Viewed by 354 | Submission Open
Keywords: breast cancer; biomarkers; molecular mechanisms; multidrug resistance; personalized medicine; molecular targeted therapy; gene expression
(This special issue belongs to the Section Cancer Biology)
Biological Foundations of Psychiatric Disorders
edited by Rammohan Shukla
submission deadline 30 Nov 2025 | Viewed by 240 | Submission Open
Keywords: psychiatric disorders; molecular mechanisms; animal models; therapeutic discovery; genetic associations; sex differences; protocols; methods; behavioral studies; stress-related phenotypes
(This special issue belongs to the Section Neuroscience)
Pathophysiology of Chronic Inflammatory Diseases
edited by Vincent Yuan
submission deadline 1 Dec 2025 | 4 articles | Viewed by 5595 | Submission Open
Keywords: chronic inflammation; autoimmune diseases; cytokines; inflammasome; metabolic dysfunction; oxidative stress; biomarkers; epigenetics; personalized medicine; therapeutic targets
(This special issue belongs to the Section Physiology)
Global Fisheries Resources, Fisheries, and Carbon-Sink Fisheries submission deadline 15 Dec 2025 | 24 articles | Viewed by 22909 | Submission Open
Keywords: fisheries; habitats; overfishing; fishery resource biology; economic aquatic animal behavior; stock enhancement by releasing; environmental DNA; fisheries management; climate change; ecosystems; ecological models; carbon-sink; aquatic ecological ranches; fisheries products
Biogeochemical Element Cycling in Plant–Soil Systems: Implications for Ecosystem Dynamics and Services
edited by and Wajid Zaman
submission deadline 15 Dec 2025 | 10 articles | Viewed by 17566 | Submission Open
Keywords: autotrophs; biomass production; climate stabilization; ecosystem functions; ecosystem management; ecosystem policy; global change; heterotrophs; pollination; soil fertility; soil macro-organisms; soil micro-organisms
(This special issue belongs to the Section Ecology)
Environmental DNA (eDNA) for Assessment of Coastal Marine Biodiversity submission deadline 15 Dec 2025 | 2 articles | Viewed by 2393 | Submission Open
Keywords: eDNA metabarcoding; coastal marine ecosystems; biodiversity; genetic distances; ecological indicators
(This special issue belongs to the Section Ecology)
Biology of Liver Diseases submission deadline 20 Dec 2025 | 3 articles | Viewed by 12607 | Submission Open
Keywords: viral hepatitis; alcoholic hepatitis; non-alcoholic steatohepatitis; autoimmune hepatitis; primary biliary cholangitis; liver cirrhosis; liver cancer; portal hypertension
(This special issue belongs to the Section Medical Biology)
Computational Modeling of Drug Delivery
edited by and Arezoo M. Ardekani
submission deadline 25 Dec 2025 | 2 articles | Viewed by 3092 | Submission Open
Keywords: computational modeling; drug delivery; computational fluid dynamics; biofluids; quantitative biotransport; mathematical models; artificial intelligence
(This special issue belongs to the Section Biophysics)
Experimental Biology 100 Years After the Foundation of the Italian Society: A Celebratory Special Issue submission deadline 31 Dec 2025 | 14 articles | Viewed by 47981 | Submission Open
Keywords: anatomy; histology; embryology; physiology; biochemistry; cell biology; genetics; pharmacology; anthropology; cancerology; pathology; microbiology; advanced microscopy and imaging; aging; aquatic environments; artificial intelligence applied to biomedicine; biodiversity and modeling; biology of reproduction and infertility; biomedical and pharmaceutical biotechnology; cellular stress; environment and health; micro- and nanovesicles in biomedicine; neuroscience; nutrition and food supplements; plant biology; precision medicine; regenerative medicine; structural biology; urban biodiversity and climate change
Adaptation of Living Species to Environmental Stress
edited by and Sonia Del Prete
submission deadline 31 Dec 2025 | 11 articles | Viewed by 34524 | Submission Open
Keywords: adaptation; environmental stress; evolutionary response; physiological adaptation; behavioral adaptation; morphological adaptation; climate change; conservation biology; biodiversity; ecological resilience; sound waves
(This special issue belongs to the Section Ecology)
Physiology and Pathophysiology of Obesity
edited by Yifei Kang
submission deadline 31 Dec 2025 | 9 articles | Viewed by 29848 | Submission Open
Keywords: dietary intervention; alternative food; food supplementation; weight loss; weight management; obesity comorbidities; obesity pathophysiology
(This special issue belongs to the Section Physiology)
Innovative Biotechnologies for Advancing Protein Function Investigation
edited by Yongjuan Zhao, Wanhua Li and Qiwen Deng
submission deadline 31 Dec 2025 | 6 articles | Viewed by 28951 | Submission Open
Keywords: protein imaging and visualization; high-throughput screening; computational methodologies; protein engineering; protein– protein interactions; protein– ligand interactions; biological mechanisms
(This special issue belongs to the Section Biotechnology)
Advances in Wildlife Conservation and Habitat Management in the Anthropocene submission deadline 31 Dec 2025 | 12 articles | Viewed by 23862 | Submission Open
Keywords: innovative technologies; advanced monitoring techniques; habitat suitability modeling; species distribution modeling; climate change scenarios; anthropogenic; biotic; and abiotic stressors; environmental impact assessments; invasive species management; disease outbreak impacts; long-term ecological monitoring; protected area effectiveness; keystone species conservation; threatened species; adaptive conservation strategies; conservation planning; wildlife conservation; habitat management
(This special issue belongs to the Section Ecology)
Physiological, Biochemical, and Molecular Response in Plants under Light-Emitting Diode (LED) Treatment (Volume II) submission deadline 31 Dec 2025 | 9 articles | Viewed by 20850 | Submission Open
Keywords: antioxidants; bioactive compounds; biotic and abiotic stress; food quality; LED; nutrients; plant defense; plant response; productivity
(This special issue belongs to the Section Plant Science)
Animal Models in Toxicology
edited by
submission deadline 31 Dec 2025 | 8 articles | Viewed by 18471 | Submission Open
Keywords: animal model; biomarker of harm; pharmacokinetics; route of exposure; toxicology; toxin
(This special issue belongs to the Section Toxicology)
Nutrition, Environment, and Fish Physiology
edited by
submission deadline 31 Dec 2025 | 11 articles | Viewed by 18316 | Submission Open
Keywords: fish; physiology; nutrition; environment; effects   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Marine Biology)
Immune Microenvironment and Molecular Mechanism of Glioma
edited by Carolina Cristina Jancic
submission deadline 31 Dec 2025 | 3 articles | Viewed by 16274 | Submission Open
Keywords: gliomas; tumor microenvironment; immune response; tumor evasion; tumor resistance; immunotherapy TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Latin   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Latin to Simplified ChinesePRO Never translate Latin Never translate admin.mdpi.com
(This special issue belongs to the Section Cancer Biology)
Molecular Mechanisms of Plant Stress Adaptation
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 14413 | Submission Open
Keywords: plant adaptation; environmental stress; molecular mechanism; genetic improvement; stress tolerance
(This special issue belongs to the Section Plant Science)
Differential Gene Expression and Coexpression (2nd Edition) submission deadline 31 Dec 2025 | 5 articles | Viewed by 11482 | Submission Open
Keywords: inflammation; cyclooxygenase 2; microsomal prostaglandin E synthase 1; cancer; epithelial mesenchymal transition; biomarkers; immunotherapy; metabolism; myeloid and lymphoid cells
(This special issue belongs to the Section Bioinformatics)
Recent Advances in Tumor Microenvironment Biology
edited by Hongbin Wang
submission deadline 31 Dec 2025 | 3 articles | Viewed by 11068 | Submission Open
Keywords: tumor microenvironment; immune cells’ stromal cells; extracellular matrix; angiogenesis; metabolic reprogramming; tumor-associated macrophages; tumor-infiltrating lymphocytes; cytokine signaling; therapeutic targeting strategies  
(This special issue belongs to the Section Cancer Biology)
Animal Models of Pancreatic Diseases
edited by Preeti Chhabra and Kenneth Brayman
submission deadline 31 Dec 2025 | 4 articles | Viewed by 10840 | Submission Open
Keywords: animal models; pancreatic diseases; pancreatitis; pancreatic cancer; diabetes; pathogenesis; therapeutic targets; preclinical testing
(This special issue belongs to the Section Physiology)
Advances in Aquatic Ecological Disasters and Toxicology
edited by and
submission deadline 31 Dec 2025 | 8 articles | Viewed by 7355 | Submission Open
Keywords: aquatic ecological disasters; aquatic toxicology; aquatic ecosystem; algal blooms; pollutants
Stem Cells in Neurological Disorders: Challenges and Opportunities
edited by Ying Liu and Qi Lin Cao
submission deadline 31 Dec 2025 | 3 articles | Viewed by 7277 | Submission Open
Keywords: stem cell research; neurological disorders; induced pluripotent stem cells (iPSCs); cell replacement therapy; gene editing in neurology; stem cell-derived exosomes; neuroregeneration; disease modeling; neuroprotective strategies; regenerative medicine
(This special issue belongs to the Section Neuroscience)
State of the Art in Fish Nutrition: Antimicrobials, Immunostimulants, Synbiotics and Alternative Protein Sources
edited by Jiun-Yan Loh
submission deadline 31 Dec 2025 | 3 articles | Viewed by 6646 | Submission Open
Keywords: probiotics; prebiotics; synbiotics; immunostimulants; antimicrobial peptides; alternative protein/single-cell protein sources; insect meals; aquatic species; metabolisms; disease resistances
(This special issue belongs to the Section Zoology)
Young Investigators in Biochemistry and Molecular Biology
edited by
submission deadline 31 Dec 2025 | 7 articles | Viewed by 5644 | Submission Open
Keywords: protein structure and function; DNA Methylation; apoptosis; computational biology; molecular development biology; molecular enzymology; molecular evolution; molecular immunology; molecular virology; systems biology; proteins and nucleic acids; protein trafficking; proteomics; structural and functional genomics; transcriptomics; signaling
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Epibiosis in Aquatic Environments submission deadline 31 Dec 2025 | 3 articles | Viewed by 4907 | Submission Open
Keywords: conservation; biodiversity; animals; aquatic environments; marine biology; marine zoology; marine ecology; radiation biology; interspecific interactions; evolution
Molecular Biology of Plants
edited by
submission deadline 31 Dec 2025 | 4 articles | Viewed by 4716 | Submission Open
Keywords: transcriptome; metabolome; genome editing; genetic modification; stress resistance; yield improvement; secondary metabolites; flowering
(This special issue belongs to the Section Plant Science)
The Potential of Genetics and Plant Breeding in Crop Improvement submission deadline 31 Dec 2025 | 6 articles | Viewed by 4683 | Submission Open
Keywords: plants; plant signaling pathways; growth and development; genomics; transcriptomics; proteomics; metabolomics; gene transformation; molecular biology; biochemistry; molecular breeding; genome editing; CRISPR/Cas9; marker-assisted selection; genome-wide selection; crop improvement; genetic diversity; quality traits; yield; disease resistance; environmental stress; plant-microbe interactions; drought tolerance; salinity resistance; oxidative stress; phytohormone
(This special issue belongs to the Section Plant Science)
Radiation and Biology: Investigating Cellular, Organismal, and Environmental Responses submission deadline 31 Dec 2025 | 3 articles | Viewed by 4253 | Submission Open
Keywords: radiation-induced DNA damage and repair pathways; oxidative stress and redox signaling in radiation response; radiation-induced epigenetic modifications; radiation-induced immunomodulation and inflammation; radiation-induced carcinogenesis and disease susceptibility; ecological consequences of ionizing radiation
(This special issue belongs to the Section Medical Biology)
Young Researchers in Plant Sciences
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 4025 | Submission Open
Keywords: biodiversity; biogeography; biotic and abiotic stress responses; carbon sequestration; ecosystem functions; gene– function relationships; photosynthesis; phytohormones; phytoremediation; plant interactions with viruses; bacteria; fungi; plants; and animals; primary and secondary metabolism; seed development; signalling pathways; structure– function simulation modelling
(This special issue belongs to the Section Plant Science)
Feeding Biology and Nutrition in Insects
edited by and Christopher W. Weldon
submission deadline 31 Dec 2025 | 3 articles | Viewed by 3972 | Submission Open
Keywords: diet; digestion; ecology; evolution; feeding; insects; mass-rearing; microbiome; nutrients; taste
(This special issue belongs to the Section Ecology)
Unveiling Novel Gene Functions: Mechanisms, Evolution and Applications
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 3790 | Submission Open
Keywords: Novel Gene Mechanisms; Molecular Pathways; Systems Biology; Moonlighting Genes; Adaptive Evolution; Synthetic Biology Applications
(This special issue belongs to the Section Genetics and Genomics)
Large Animal Experimental and Epidemiological Models for Diseases submission deadline 31 Dec 2025 | 2 articles | Viewed by 3777 | Submission Open
Keywords: large animal model; dog; pig; ruminants; experimental study; epidemiological study; infectious diseases; non-infectious diseases; treatment; disease control; disease prediction
(This special issue belongs to the Section Medical Biology)
Arthropods as Vectors of Human and Animal Pathogens: Vector Ecology and Disease Transmission
edited by Panpim Thongsripong
submission deadline 31 Dec 2025 | 4 articles | Viewed by 3397 | Submission Open
Keywords: vector; disease ecology; vector-borne pathogens; mosquito; tick; flies; sandflies; triatomine; tsetse; fleas; mites
(This special issue belongs to the Section Infection Biology)
Insecticide Resistance: Molecular Mechanisms and Ecological Implications
edited by Kaikai Mao
submission deadline 31 Dec 2025 | 1 articles | Viewed by 3318 | Submission Open
Keywords: insecticide resistance; molecular mechanism; regulatory network; ecological impact; non-target impact; resistance genes; pest resistance management
(This special issue belongs to the Section Ecology)
Sustainable Management of Aquatic Animal Health: Advances in Immunology, Pathogenesis, and Innovative Disease Control Strategies
edited by and
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2892 | Submission Open
Keywords: aquatic animal health; immunology; pathogenesis; CRISPR-based innovations; sustainable aquaculture
(This special issue belongs to the Section Immunology)
Responses and Resistance Mechanisms of Plants Under Environmental Stress
edited by
submission deadline 31 Dec 2025 | 3 articles | Viewed by 2745 | Submission Open
Keywords: disease resistance; cold tolerance; defense priming; pathogen perception
(This special issue belongs to the Section Plant Science)
Mechanisms of Genetic and Epigenetic Regulation Underlying Plant Resistance
edited by Feng Zhang, and
submission deadline 31 Dec 2025 | 5 articles | Viewed by 2584 | Submission Open
Keywords: plant biotic and abiotic stresses; multi-omics; genetic engineering; genome editing; epigenetic regulation
(This special issue belongs to the Section Plant Science)
The Application of Microorganisms and Plants in Soil Improvement submission deadline 31 Dec 2025 | 2 articles | Viewed by 2240 | Submission Open
Keywords: environmental microbiology; microbial diversity; microbial metabolism; nutrient transformation; plant growth promotion; rhizosphere effect; soil improvement
(This special issue belongs to the Section Microbiology)
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