Radiation and Biology: Investigating Cellular, Organismal, and Environmental Responses

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Medical Biology".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 342

Special Issue Editors


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Guest Editor
Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand
Interests: radiation biology; clinical radiobiology; cancer biomarkers; environmental health
Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
Interests: radiogenotoxicity; radioadaptation; radiocarcinogenesis; nutrition and lifestyle; proactive radiation protection
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan
Interests: DNA damage response; DNA damage repair; chromosomal aberration; reactive oxygen species; nutrition and lifestyle
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Molecular Imaging and Therapy Research Unit, Department of Radiologic Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand
Interests: radiobiology; cancer radiotherapy and radiosensitizer; cancer stem cell; molecular imaging; multidrug resistance in cancer; Thai medicinal plant

Special Issue Information

Dear Colleagues,

Radiation exposure, whether from natural sources or human activities, exerts diverse biological effects at multiple levels, from molecular and cellular processes to whole-organism physiology and ecosystem dynamics. Understanding these effects is essential for advancing research in radiation biology, environmental science, medicine, and space exploration.

This Special Issue serves as a comprehensive platform for studies on radiation-induced biological responses, with a particular focus on cellular mechanisms, organismal health, and ecological consequences. We welcome original research articles, reviews, and perspectives that deepen our understanding of the mechanisms underlying radiation responses, adaptive processes, and long-term biological effects across diverse systems.

Topics of Interest (including but not limited to):

  • Cellular and Molecular Mechanisms of Radiation Response:
    • DNA damage, repair pathways, and genomic stability;
    • Oxidative stress, redox homeostasis, and metabolic alterations;
    • Epigenetic modifications and radiation-induced gene regulation;
    • Mechanisms of radiation-induced cell death, senescence, and adaptation.
  • Organismal and Physiological Effects:
    • Radiation effects on animal and human health;
    • Immune system modulation and inflammatory responses;
    • Carcinogenesis and disease susceptibility in irradiated organisms;
    • Mechanisms of radiation resistance and physiological adaptation.
  • Ecological and Environmental Impacts:
    • Radiation-induced changes in biodiversity and ecosystem function;
    • Species-specific radiation tolerance and adaptive strategies;
    • Long-term ecological consequences of radiation exposure;
    • Implications of space radiation for biological systems.
  • Translational and Applied Research:
    • Advances in radioprotective strategies for humans and wildlife;
    • Biomarkers for radiation exposure and risk assessment;
    • Novel approaches in radiotherapy and radiation mitigation;
    • Ethical and regulatory considerations in radiation biology research.

This Special Issue seeks to offer novel insights into the impact of radiation on biological systems across varying levels of complexity by integrating research from multiple disciplines. We invite submissions that enhance the fundamental understanding of radiation biology and its relevance to health, environmental sustainability, and technological applications.

Dr. Narongchai Autsavapromporn
Dr. Bing Wang
Dr. Takanori Katsube
Dr. Jiraporn Kantapan
Guest Editors

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Keywords

  • radiation-induced DNA damage and repair pathways
  • oxidative stress and redox signaling in radiation response
  • radiation-induced epigenetic modifications
  • radiation-induced immunomodulation and inflammation
  • radiation-induced carcinogenesis and disease susceptibility
  • ecological consequences of ionizing radiation

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Published Papers (1 paper)

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Research

15 pages, 2236 KiB  
Article
Comparison of Tumor Cell Responses to Different Radiotherapy Techniques: Three-Dimensional Conformal Radiotherapy (3D-CRT), Volumetric Modulated Arc Therapy (VMAT), and Helical Tomotherapy (HT)
by Phanwadee Kasetthamrongrat, Rinwarat Phumsankhot, Aphidet Duangya, Anirut Watcharawipha, Wannapha Nobnop and Narongchai Autsavapromporn
Biology 2025, 14(5), 529; https://doi.org/10.3390/biology14050529 - 10 May 2025
Viewed by 65
Abstract
Currently, advanced RT techniques such as VMAT and HT are being developed to optimize tumor coverage while minimizing radiation exposure to the surrounding organs that are at risk. Despite their growing clinical use, comparative studies evaluating the dosimetric and radiobiological effects of these [...] Read more.
Currently, advanced RT techniques such as VMAT and HT are being developed to optimize tumor coverage while minimizing radiation exposure to the surrounding organs that are at risk. Despite their growing clinical use, comparative studies evaluating the dosimetric and radiobiological effects of these modalities remain limited. In this study, A549, HeLa, and HepG2 cells were exposed to a single 2 Gy dose, using three RT techniques (3D-CRT, dual arc VMAT, and HT). Treatment plans were generated using a water phantom to ensure consistent target coverage and comparable dosimetric parameters across the techniques. Multiple radiobiological endpoints were assessed to evaluate the cellular responses. Although all three techniques yielded similar dosimetric parameters without statistically significant differences, the biological responses varied among the cell lines. Notably, VMAT and HT demonstrated superior tumor cell suppression compared to 3D-CRT. This was likely due to their enhanced dose conformity and modulation precision, which potentially led to improved tumor cell killing. These findings highlight the importance of integrating radiobiological assessments with physical dose metrics to inform the clinical application of advanced RT technologies. However, this study had several limitations. The use of a single radiation dose limited its clinical relevance, and the immediate post-irradiation assessments may not have captured delayed biological responses. Additionally, the small number of replicates may have reduced the study’s statistical power. Future studies incorporating dose fractionation schemes, time course analyses, and larger sample sizes are warranted to better simulate clinical conditions and further elucidate the radiobiological effects of advanced RT techniques. Full article
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