Special Issues

Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Leishmaniasis and Chagas Disease: Biology, Epidemiology, Treatment and Control (2nd Edition) submission deadline 31 Aug 2026 | 1 articles | Viewed by 1120 | Submission Open
Keywords: leishmaniasis; Chagas disease; immunopathogeny; diagnosis; epidemiology; control; vaccine
Bone Mechanics: From Cells to Organs, to Function submission deadline 31 Aug 2026 | 1 articles | Viewed by 764 | Submission Open
Keywords: bone mechanics; bone remodeling; mechanotransduction; structural analysis; functional morphology; bioengineering
(This special issue belongs to the Section Physiology)
Microbiology and Metabolomics in Reproductive Biology submission deadline 31 Aug 2026 | Viewed by 373 | Submission Open
Keywords: maternal microbiome; metabolome; pregnancy outcomes; fetal development; biomarkers; immune function; metabolic health; disease prediction; therapeutic interventions; maternal and child health
(This special issue belongs to the Section Developmental and Reproductive Biology)
Sickle Cell Disease: Molecular Mechanisms, Pathogenesis and Therapies
edited by Chithra Palani
submission deadline 31 Aug 2026 | Viewed by 364 | Submission Open
Keywords: SCD; anemia; erythrocyte development; erythroid progenitors; CD34 cells; vaso-occlusion; pain crisis; hemolysis; oxidative stress; sickling; inflammation; ER stress; fetal hemoglobin; hematopoiesis; ischemia and tissue damage; organ damage; drug development; SCD diagnosis; gene therapy; cell therapy
(This special issue belongs to the Section Medical Biology)
Energy Metabolism, Genetics and Development in Drosophila
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 346 | Submission Open
Keywords: Drosophila; energy metabolism; development; epigenetics; non-coding RNAs; metabolic disease; growth; signaling pathway
(This special issue belongs to the Section Bioinformatics)
Fruits and Seeds of Tropical Plants: Conservation of Species, Ecological Importance and Quality Valorization
edited by Edna Ursulino Alves and Silvanda De Melo Silva
submission deadline 31 Aug 2026 | 1 articles | Viewed by 330 | Submission Open
Keywords: climate change; nature conservation; biodiversity; plant propagation; postharvest quality; metabolic profile; orchard management and quality
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Advances in Cardiac and Vascular Biology: From Mechanisms to Pathophysiology
edited by and
submission deadline 31 Aug 2026 | Viewed by 267 | Submission Open
Keywords: cardiovascular biology; molecular mechanisms; cellular signaling; epigenomic regulation; vascular remodeling; metabolic reprogramming; cardiac pathophysiology
(This special issue belongs to the Section Physiology)
Biophysics of Exposome: Molecular Mechanisms of Action
edited by and Madhavi K. Ganapathiraju
submission deadline 31 Aug 2026 | Viewed by 176 | Submission Open
Keywords: computational biology; systems biology; mass spectrometry; protein– ligand networks; protein– protein interaction networks; metabolomics; proteomics; surface plasmon resonance; protein structure prediction; molecular docking; target fishing; machine learning; artificial intelligence
Current Status and Future Perspectives on Lipid Biology and Beyond submission deadline 31 Aug 2026 | Viewed by 166 | Submission Open
Keywords: lipids; fatty acids (FAs); omega-3 (FA); omega-6 (FA); cancer; cell biology; oxylipins; oxidative stress; lipidomics; lipid nanoparticles; personalized lipid-based therapies
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Mitochondrial Genomics of Arthropods
edited by Renfu Shao
submission deadline 31 Aug 2026 | Viewed by 106 | Submission Open
Keywords: mitochondrial genome architecture; transcriptional dynamics; translational mechanisms; comparative genomics; molecular evolution; arthropod phylogenetics; systematics; evolutionary biology
(This special issue belongs to the Section Genetics and Genomics)
Research Progress on Metabolic Pathways in Neurodegenerative Diseases
edited by Ali H. Rafati
submission deadline 31 Aug 2026 | Viewed by 103 | Submission Open
Keywords: neurodegeneration; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; autophagy; neuroinflammation; biomarkers; therapeutic targets
(This special issue belongs to the Section Neuroscience)
Novel Mechanisms and Biological Processes in Redox and Inflammatory Signaling
edited by Shengchen Wang and
submission deadline 31 Aug 2026 | Viewed by 76 | Submission Open
Keywords: redox; inflammatory; oxidative stress; antioxidant; anti-inflammatory; signaling pathways
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Biogenesis and Function of Centrioles, Centrosomes, and Primary Cilia in Health and Disease submission deadline 31 Aug 2026 | Viewed by 61 | Submission Open
Keywords: centriole; centrosome; cilia
(This special issue belongs to the Section Cell Biology)
Uncovering the Role of T Cells in Immune Homeostasis and Immune Tolerance
edited by
submission deadline 31 Aug 2026 | Viewed by 37 | Submission Open
Keywords: regulatory T cells; immune tolerance; FOXP3; cytokine; suppression
(This special issue belongs to the Section Cell Biology)
Biological Invasions in Freshwater Ecosystems
edited by Filipe Banha
submission deadline 31 Aug 2026 | Submission Open
Keywords: invasive species; rivers; lakes; ecology; biology; impacts
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Biosynthesis of Metabolites from Microorganisms, or Microorganism-Host Interaction? (Volume II) submission deadline 1 Sep 2026 | 6 articles | Viewed by 18054 | Submission Open
Keywords: biosynthesis; biological activity; biosynthesis regulation; microbial metabolites; microbe– host reaction
(This special issue belongs to the Section Microbiology)
Viral Infections in Animals: Pathogenesis and Immunity
edited by
submission deadline 1 Sep 2026 | 1 articles | Viewed by 1758 | Submission Open
Keywords: virus– host interactions; antiviral immunity; mechanisms of viral pathogenesis
(This special issue belongs to the Section Immunology)
Latest Discoveries in Non-Model Organisms and Non-Translational Biology submission deadline 8 Sep 2026 | Viewed by 158 | Submission Open
Keywords: basic biological research; non-translational biology; non-clinical biology; fundamental science; non-model organisms; model organisms; scientific curiosity– driven research; biological diversity; experimental biology; theoretical biology
Feature Papers on Developmental and Reproductive Biology
edited by
submission deadline 15 Sep 2026 | 11 articles | Viewed by 28194 | Submission Open
Keywords: embryo/fetus development; reproductive biology; gametogenesis; differentiation; growth; homeostasis; regeneration; aging; cell cycle regulation; stem cells; organoids
(This special issue belongs to the Section Developmental and Reproductive Biology)
Molecular and Cellular Mechanisms of Neuroinflammation and Chronic Pain
edited by Mario Garcia-Dominguez
submission deadline 15 Sep 2026 | Viewed by 50 | Submission Open
Keywords: neuroinflammation; chronic pain; neuroimmune interactions; glial activation; cytokine signaling; synaptic plasticity; oxidative stress; epigenetic regulation; microglia and astrocytes; therapeutic targets
(This special issue belongs to the Section Neuroscience)
Plant Breeding: From Biology to Biotechnology
edited by Juwu Gong
submission deadline 30 Sep 2026 | 5 articles | Viewed by 8467 | Submission Open
Keywords: plant breeding; biotechnology; molecular marker-assisted selection; genetic engineering; genome editing; tissue culture; phenotype; genetics; omics
(This special issue belongs to the Section Biotechnology)
Signalling Pathways in Cancer and Disease submission deadline 30 Sep 2026 | 5 articles | Viewed by 6077 | Submission Open
Keywords: cancer; signalling; metastasis; tumorigenesis; cancer targeting
(This special issue belongs to the Section Cancer Biology)
Molecular Basis of Bone Homeostasis and Skeletal Diseases
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 5587 | Submission Open
Keywords: osteoclast; osteoblast; bone; skeletal disease; bone formation; bone resorption; osteoporosis; osteopetrosis; human genetics; mouse genetics
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Large Animal Experimental and Epidemiological Models for Diseases submission deadline 30 Sep 2026 | 3 articles | Viewed by 4906 | Submission Open
Keywords: large animal model; dog; pig; ruminants; experimental study; epidemiological study; infectious diseases; non-infectious diseases; treatment; disease control; disease prediction
(This special issue belongs to the Section Medical Biology)
Research Advancements in Oral Biology
edited by and Nina Petrović
submission deadline 30 Sep 2026 | 2 articles | Viewed by 3953 | Submission Open
Keywords: oral biology; oral tissue regeneration; artificial intelligence (AI) in dentistry; genomics and proteomics in dentistry; dental research; salivary diagnostics
(This special issue belongs to the Section Medical Biology)
The Role of Innate Immunity in Organ Transplantation
edited by Todd V. Brennan
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1732 | Submission Open
Keywords: innate immunity; allograft rejection; transplantation; immune tolerance
(This special issue belongs to the Section Medical Biology)
Molecular Mechanisms of Cell Signal Transduction
edited by
submission deadline 30 Sep 2026 | Viewed by 508 | Submission Open
Keywords: molecular interactions in signaling; phosphorylation and signal propagation; post-translational modifications; cross-talk between signaling pathways; cellular response to extracellular stimuli; metabolic regulation and signaling; signaling in cancer progression; inflammatory signaling pathways; role of signaling in stem cell differentiation; innovative imaging techniques for signaling
(This special issue belongs to the Section Cell Biology)
Physiology and Ecology of Animal Parasites and Related Diseases
edited by Marcela K. Castelo
submission deadline 30 Sep 2026 | Viewed by 423 | Submission Open
Keywords: parasites; parasitoids; physiology; ecology; ecophysiology; diseases; global change
(This special issue belongs to the Section Zoology)
More than a Shield: The Secret Functions of Epithelial Cells in Homeostasis and Infections
edited by and Na Zhao
submission deadline 30 Sep 2026 | Viewed by 251 | Submission Open
Keywords: epithelial diversity; signaling; homeostasis; immunity; infection; microbiome; inflammation; cytokines; antimicrobial peptides
(This special issue belongs to the Section Medical Biology)
Bone Physiology and Development
edited by , and Yohei Abe
submission deadline 30 Sep 2026 | Viewed by 121 | Submission Open
Keywords: osteology; osteogenesis; bone growth; bone physiology; bone morphology; bone pathology; bone imaging
(This special issue belongs to the Section Physiology)
Gut Microbiome in Health and Disease (3rd Edition)
edited by and
submission deadline 30 Sep 2026 | Viewed by 119 | Submission Open
Keywords: gut microbiota; ‘ gut– X’ axis; dysbiosis; food nutrition; metabolites; type 2 diabetes mellitus; gut health; immunity
(This special issue belongs to the Section Microbiology)
The Molecular and Cellular Mechanisms of Lung Injury and Recovery
edited by Weiguo Chen, HongLong Ji and Ibra S. Fancher
submission deadline 30 Sep 2026 | Viewed by 103 | Submission Open
Keywords: acute lung injury; chronic lung injury; ARDS; fibrosis; allergy; mechanisms; therapy; infection; inflammation; endothelial barrier
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Molecular Mechanisms of Retina Development and Degeneration submission deadline 30 Sep 2026 | Viewed by 102 | Submission Open
Keywords: retina; retinal development; retinal degeneration; molecular mechanisms; signaling pathways; genetic regulation; epigenetics; neuronal and glial interactions; neuroinflammation
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Innovative Approaches to Rice Crop Production Under Environmental Stresses submission deadline 30 Sep 2026 | Viewed by 65 | Submission Open
Keywords: abiotic stress; environmental stress response; stress adaptation; DNA damage and repair; functional genomics; plant physiology; biofortification
(This special issue belongs to the Section Genetics and Genomics)
Pathogenic Mechanisms Involved in Development and Progression of ROS-Associated Diseases
edited by
submission deadline 30 Sep 2026 | Viewed by 60 | Submission Open
Keywords: Reactive Oxygen Species (ROS); oxidative stress; pathogenic mechanisms; disease progression; mitochondrial dysfunction; inflammation and immune regulation; redox biology; molecular signaling pathways; antioxidants and therapeutics; comparative medicine; One Health; translational research
(This special issue belongs to the Section Biochemistry and Molecular Biology)
Genetics and Epigenetics of Neurological Disorders submission deadline 30 Sep 2026 | Viewed by 32 | Submission Open
Keywords: neurological disorders; neurogenetics; genomics; epigenomics; DNA methylation; precision medicine
(This special issue belongs to the Section Neuroscience)
Ecological Interactions and Adaptive Strategies in Wildlife
edited by
submission deadline 30 Sep 2026 | Viewed by 29 | Submission Open
Keywords: biological pest control; predator– prey dynamics; avian reproductive ecology; evolutionary traits; human– wildlife coexistence; invasive species impacts; artificial nest ecology; ecosystem
(This special issue belongs to the Section Conservation Biology and Biodiversity)
Coral Physiological Plasticity and Environmental Adaptation: From Molecular Mechanisms to Ecosystem Resilience submission deadline 30 Sep 2026 | Viewed by 28 | Submission Open
Keywords: environmental stressors; physiological plasticity; climate resilience; molecular mechanisms; coral symbiosis; adaptive potential; ocean acidification; thermal tolerance
(This special issue belongs to the Section Marine and Freshwater Biology)
Antibiotic Resistance Mechanisms: Ecological Implications
edited by
submission deadline 30 Sep 2026 | Viewed by 2 | Submission Open
Keywords: antibiotic resistance in environmental bacteria; antibiotics in the environment; ecological consequences of antibiotic resistance; antibiotic synergies and antagonisms with environmental pollutants; biomarkers of antibiotic resistance in the environment
(This special issue belongs to the Section Microbiology)
Pollination Biology: 2nd Edition
edited by and
submission deadline 1 Oct 2026 | Viewed by 144 | Submission Open
Keywords: conservation biology; insect diversity; pollinator-plant interactions; ecosystem service; pollinating insect; flower; bee
(This special issue belongs to the Section Ecology)
Semaphorins as Drivers of Inflammatory Disease: Setting Immune Cells in Motion
edited by
submission deadline 3 Oct 2026 | Viewed by 65 | Submission Open
Keywords: semaphorins; inflammation; neuronal guidance proteins; soluble guidance cues; cell motility; cytoskeletal dynamics; extracellular matrix
(This special issue belongs to the Section Immunology)
Multi-omics Approaches in Agricultural Crops to Unravel Responses to Environmental Stresses and Advance Sustainable Agriculture
edited by
submission deadline 30 Oct 2026 | 2 articles | Viewed by 6027 | Submission Open
Keywords: plant functional genomics; environmental stress; climate change; crop yield; crop quality; nutritional properties; omics approaches; genomics; transcriptomics; proteomics; metabolomics; epigenomics; phenomics; stress-tolerant crops; breeding strategies; data integration; systems biology; sustainable agriculture; underutilized crops; orphan crops; beneficial microorganisms
(This special issue belongs to the Section Plant Science)
Pathophysiology of Hearing Loss
edited by Charles E. Bishop
submission deadline 30 Oct 2026 | 2 articles | Viewed by 2468 | Submission Open
Keywords: hearing loss; cochlea; noise; deafness genes; cell death; hair cells; inner ear; biotoxicity; metabolic risk; gene mutation; physiology and pathophysiology; animal models; biomarkers and molecular mechanisms
(This special issue belongs to the Section Physiology)
Molecular, Biophysical, and Neurophysiological Mechanisms Underlying Magnetoreception
edited by and
submission deadline 30 Oct 2026 | Viewed by 156 | Submission Open
Keywords: earth magnetic field; magnetosensing; magnetite; radical pair; orientation; navigation; magnetic receptor; electroreceptor; neurophysiology
Animal Virus–Host Interactions and Cross-Species Dynamics submission deadline 30 Oct 2026 | Viewed by 118 | Submission Open
Keywords: animal viruses; zoonosis; pathogenesis; host immunity; vaccines; antivirals; host– pathogen interaction; One Health; veterinary virology
(This special issue belongs to the Section Infection Biology)
Fatty Acid Metabolism and Inflammation
edited by
submission deadline 30 Oct 2026 | Viewed by 90 | Submission Open
Keywords: fatty acid metabolism; metabolic dysfunction; mitochondrial impairment; oxidative stress; glucose metabolism; lipid metabolism; Immune modulation; Inflammation; biomarkers
(This special issue belongs to the Section Physiology)
Advances in Zebrafish as an Experimental Model: From Husbandry to Cutting-Edge Applications
edited by Rosario Moyano-Salvago, and
submission deadline 30 Oct 2026 | Viewed by 41 | Submission Open
Keywords: zebrafish; experimental model; developmental biology; genetics; gene editing; transgenesis; toxicology; regeneration; animal welfare; biomedical research
(This special issue belongs to the Section Zoology)
Immunosenescence and Its Modification by Interventions
edited by and Luca Pangrazzi
submission deadline 31 Oct 2026 | 1 articles | Viewed by 6525 | Submission Open
Keywords: immunosenescence; aging immune system; inflammaging; vaccine efficacy in elderly; nutritional immunomodulation; exercise and immunity; senolytic therapies; T-cell exhaustion; thymic rejuvenation; age-related diseases
(This special issue belongs to the Section Immunology)
Mitochondria and Cardiovascular Diseases
edited by Qingxun Hu
submission deadline 31 Oct 2026 | 1 articles | Viewed by 3411 | Submission Open
Keywords: cardiovascular diseases; mitochondria; pathophysiology; cardiology; cell metabolism; animal models; epigenetics; redox biology
(This special issue belongs to the Section Physiology)
Advances in Plant Multi-Omics
edited by , Zhonglong Guo and Xuekai Wei
submission deadline 31 Oct 2026 | 1 articles | Viewed by 691 | Submission Open
Keywords: multi-omics integration; plant systems biology; high-throughput sequencing; bioinformatics integration; stress response
(This special issue belongs to the Section Plant Science)
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