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Antioxidants publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Lipid Peroxidation: Molecular Mechanisms and Systemic Responses

edited by

Morana Jaganjac

submission deadline 20 Feb 2027 | Viewed by 478 | Submission Open

Keywords: redox homeostasis; lipid peroxidation; cellular function; tissue remodeling; systemic alterations

(This special issue belongs to the Section Aberrant Oxidation of Biomolecules)

Redox Signaling in Brain Aging and Neurodegeneration

edited by Marco Bisaglia

submission deadline 28 Feb 2027 | 4 articles | Viewed by 7814 | Submission Open

Keywords: aging; autophagy; brain; Alzheimer disease; amyotrophic lateral sclerosis; Friedreich ataxia; Huntington disease; neurodegeneration; oxidative stress; protein aggregation; Parkinson’s disease; reactive oxygen species

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Role of Oxidative Stress in Cardiac Remodeling and Heart Failure—3rd Edition

edited by

Marina Politi Okoshi

Elida Paula Benquique Ojopi

and

Luana Urbano Pagan

submission deadline 28 Feb 2027 | 3 articles | Viewed by 6019 | Submission Open

Keywords: oxidative stress; heart disease; cardiac remodeling; signaling pathways; remodeling; left ventricular dysfunction; heart failure; cardiovascular disease; myocardial damage

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Male Reproductive Health—2nd Edition

edited by

Robert John Aitken

and

Joel R. Drevet

submission deadline 28 Feb 2027 | 7 articles | Viewed by 5335 | Submission Open

Keywords: oxidative stress; antioxidant therapy; male reproductive health; male fertility; erectile dysfunction; prostatic disease; male ageing

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants and Antioxidant Mechanisms in the Prevention and Treatment of Infectious Diseases

edited by

Gabriele Carullo

Maria Dichiara

Valeria Tudino

and Sara Rossi

submission deadline 28 Feb 2027 | 2 articles | Viewed by 4529 | Submission Open

Keywords: antioxidants; infectious diseases; quorum sensing; inflammation; natural and synthetic antioxidants; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Mitochondrial Dysfunction and Oxidative Stress in Aging and Age-Related Disorders

edited by

Dharendra Thapa

submission deadline 28 Feb 2027 | 3 articles | Viewed by 3858 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; aging; age-related diseases; mitochondrial biogenesis; reactive oxygen species (ROS); mitochondrial quality control; redox homeostasis; cellular senescence; neurodegeneration

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Cancers

edited by

Jessica Ruzzolini

and

Silvia Peppicelli

submission deadline 28 Feb 2027 | 3 articles | Viewed by 2308 | Submission Open

Keywords: cancer; oxidative stress; ROS; antioxidants; combined therapy; cellular death

Oxidative Stress in Diabetic Retinopathy and Other Retinal Diseases

edited by

Kwon-Soo Ha

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1645 | Submission Open

Keywords: vascular dysfunction; oxidative stress; mitochondrial dynamics; neurovascular dysfunction; diabetic retinopathy; age-related macular degeneration; retinal vein occlusion

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Oxidative Stress, Mitochondrial Dysfunction and Antioxidant Therapies in Endocrine and Metabolic Disorders

edited by

Adriana Florinela Càtoi

and Lia Oxana Usatiuc

submission deadline 28 Feb 2027 | 3 articles | Viewed by 1441 | Submission Open

Keywords: reactive oxygen species (ROS); mitochondrial bioenergetics; insulin resistance; antioxidant therapy

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Antioxidants in Food Safety and Quality

edited by

Monica Rosa Loizzo

submission deadline 28 Feb 2027 | 1 articles | Viewed by 1259 | Submission Open

Keywords: antioxidants; food safety; food quality; oxidative stability; lipid oxidation; prevention of protein oxidation; natural antioxidants; bioactive compounds; food processing; shelf life; innovative strategies in food quality and safety; active and intelligent packaging; antioxidant capacity; sustainable food systems; by-product valorisation; food contaminants

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Stress Induced by Environmental Pollutants

edited by

Amie K. Lund

submission deadline 28 Feb 2027 | 2 articles | Viewed by 961 | Submission Open

Keywords: environmental pollutants; redox balance; reactive oxygen species; chronic diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Reactive Oxygen Species and Growth Factors in Photodynamic Therapy (PDT), Photobiomodulation (PBM), and Radiation Therapy (RT)—2nd Edition

edited by Timothy C. Zhu and Brian C. Wilson

submission deadline 28 Feb 2027 | 1 articles | Viewed by 956 | Submission Open

Keywords: reactive oxygen species (ROS); singlet oxygen (SO); radiation; photodynamic therapy; cancers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

The Role of Oxidative Stress in Chronic Pain and Inflammation

edited by

Lucia Carmela Passacatini

and

Saverio Nucera

submission deadline 28 Feb 2027 | 1 articles | Viewed by 781 | Submission Open

Keywords: chronic pain; oxidative stress; antioxidant; inflammation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Transition Metal-Based Nanoparticles as Antioxidant Platforms for Biomedical and Cosmetic Applications

edited by

Ionut-Iulian Lungu

and

Oana Cioanca

submission deadline 28 Feb 2027 | 1 articles | Viewed by 758 | Submission Open

Keywords: transition metal nanoparticles; nanozymes; oxidative stress; reactive oxygen species (ROS); antioxidant activity; biomedical applications; cosmetic formulations; biocompatibility; nanotechnology; surface functionalization

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidant Strategies in Animal and Microbial Systems

edited by Fusheng Quan and

Zhiming Xu

submission deadline 28 Feb 2027 | 1 articles | Viewed by 440 | Submission Open

Keywords: antioxidant strategies; gut microbiota; redox homeostasis; multi-omics; dietary modulation

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Vitamin C in Cancer Therapy

edited by

Qi Chen

submission deadline 28 Feb 2027 | Viewed by 330 | Submission Open

Keywords: vitamin C; pharmacologic ascorbate; cancer therapy; redox biology; cancer metabolism; epigenetics; tumor microenvironment; combination therapy; immunotherapy; clinical trials

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Antioxidants from Circular Systems in Aquaculture: Bridging Sustainable Sourcing and Host Resilience

edited by Roberta Imperatore and

Gaetana Napolitano

submission deadline 28 Feb 2027 | Viewed by 251 | Submission Open

Keywords: circular valorization; waste-derived polyphenols; host–microbiota interactions; redox homeostasis; intestinal barrier function; aquaculture oxidative stress; metabolomics biomarkers; antioxidants; Nrf2 signaling

Hypoxia-Driven Redox Signaling: From Molecular Mechanisms to Therapeutic Opportunities

edited by

Daniel Carneiro Moreira

submission deadline 28 Feb 2027 | Viewed by 164 | Submission Open

Keywords: hypoxia; redox; ROS signaling; oxidative stress

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Radioprotective Effects of Antioxidants—2nd Edition

edited by

Ruth Edge

Homer S. Black

and

George Truscott

submission deadline 28 Feb 2027 | Viewed by 162 | Submission Open

Keywords: radiation protection; free radicals; reactive oxygen species; UV photoprotection; radiation injury

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Redox Homeostasis and Mitochondrial Function in Acute Kidney Injury

edited by

Adalberto Vieyra

and

Humberto Muzi-Filho

submission deadline 28 Feb 2027 | Viewed by 146 | Submission Open

Keywords: acute kidney injury; renal ischemia/reperfusion; mitochondrial biology; oxidative stress; inflammatory signaling; early biomarkers; chronic kidney disease progression; renal repair and regeneration

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Alcohol-Induced Oxidative Stress in Health and Disease, 3rd Edition

edited by

Marco Fiore

submission deadline 28 Feb 2027 | Viewed by 141 | Submission Open

Keywords: alcohol consumption; alcohol use disorder; ethanol metabolism; redox homeostasis; oxidative injury

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Products for Neuroprotection: Antioxidant Mechanisms and Therapeutic Potential

edited by

Silvia Bisti

and

Ilaria Piano

submission deadline 28 Feb 2027 | Viewed by 129 | Submission Open

Keywords: neurodegenerative diseases; natural products; chemical composition; neuroprotection; oxidative stress; neuroinflammation; translational medicine

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

New and Forgotten Oxidative Pathways in Diabetic Complications: From Glycation, Neutrophil Activation to Gut Microbiome Modulation

edited by Nordin Hanssen and

Philippe Vangrieken

submission deadline 28 Feb 2027 | Viewed by 95 | Submission Open

Keywords: glycation; diabetic complications; oxidative stress; inflammageing; microbiome

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Antioxidants in Skin Diseases and Skin Health

edited by

Cristina Mitran

and

Madalina Mitran

submission deadline 28 Feb 2027 | Viewed by 87 | Submission Open

Keywords: oxidative stress; antioxidants; inflammatory skin disorders; skin aging; therapy; biomarkers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Neuroprotection and Oxidative Stress: From Molecular Mechanisms to Therapeutic Strategies

edited by

Elzbieta Salinska

submission deadline 28 Feb 2027 | Viewed by 86 | Submission Open

Keywords: oxidative stress; neurodegeneration; reactive oxygen species (ROS); neuroprotection; therapeutic strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress and Inflammation in Cancer Biology—2nd Edition

edited by

Jorge Sastre-Serra

and

Mercedes Nadal-Serrano

submission deadline 28 Feb 2027 | Viewed by 80 | Submission Open

Keywords: oxidative stress; inflammation; signaling pathways; tumor microenvironment; biomarkers

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Green Extraction of Antioxidant from Natural Source—2nd Edition

edited by

Jolanta Flieger

submission deadline 28 Feb 2027 | Viewed by 67 | Submission Open

Keywords: green extraction techniques; supercritical fluid extraction; ionic liquid (IL)-based extraction; microwave-assisted extraction; antioxidants; plants; cosmetic formulation

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Thiol–Redox-Mediated Cell Death in Human Disease: Pathogenic Mechanisms and Therapeutic Intervention

edited by

Jun Lu

and

Jianqiang Xu

submission deadline 28 Feb 2027 | Viewed by 64 | Submission Open

Keywords: thiol; redox regulation; thioredoxin; glutaredoxin; selenoprotein; pathogenesis; therapy; antioxidant; inflammation; metabolism; cell death

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Plant Redox Biology Research

edited by Yurong Xie and Ming Chang

submission deadline 10 Mar 2027 | 8 articles | Viewed by 6967 | Submission Open

Keywords: plant redox biology; reactive oxygen species; reactive nitrogen species; plant development; environmental stress; abiotic/biotic stresses; host–microbe interactions

(This special issue belongs to the Section ROS, RNS and RSS)

Phenolic Compounds from Novel Natural Sources and Fermented Foods

edited by

Harris Papapostolou

and

Maria Alexandri

submission deadline 10 Mar 2027 | Viewed by 360 | Submission Open

Keywords: phenolic compounds; plant-derived antioxidants; fermentation; foods

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Oxidative Stress and Antioxidant Strategies for Eye Diseases

edited by Tatsuya Mimura

submission deadline 15 Mar 2027 | Viewed by 124 | Submission Open

Keywords: oxidative stress; ocular diseases; reactive oxygen species; antioxidant-based therapeutic strategies; retinal diseases

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in Redox Biochemistry of Cognitive Impairment Pathogenesis and Treatment

edited by Robert T. Mallet,

Xiangrong Shi

and

Liang-Jun Yan

submission deadline 20 Mar 2027 | 3 articles | Viewed by 1655 | Submission Open

Keywords: aging; antioxidants; brain; cognitive decline; inflammation; models; reactive oxygen species; therapeutic interventions

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Technological and Biological Function of Antioxidants in Animal Nutrition

edited by

Evangelos Zoidis

submission deadline 20 Mar 2027 | 1 articles | Viewed by 968 | Submission Open

Keywords: antioxidants; bioactive compounds; essential oils; animal nutrition; nano-particles; oxidative stress; polyphenols; radical scavenging; trace elements; vitamins

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Statins as Antioxidants: Beyond Their Cholesterol Lowering Activity

edited by

Arianna Vignini

and Sonila Alia

submission deadline 20 Mar 2027 | Viewed by 747 | Submission Open

Keywords: statins; cholesterol; HMGCoA reductase; antioxidant; anti-inflammatory; dysmetabolic diseases

Oxidative Stress in Diabetic Kidney Disease

edited by John S. D. Chan

submission deadline 20 Mar 2027 | 1 articles | Viewed by 354 | Submission Open

Keywords: diabetic kidney disease; reactive oxygen species; mitochondrial oxidative stress; anti-oxidant molecules; molecular mechanisms

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Plant Materials and Their Antioxidant Potential, 3rd Edition

edited by

Elisabeta Irina Geana

and

Ovidiu Tita

submission deadline 30 Mar 2027 | 7 articles | Viewed by 8703 | Submission Open

Keywords: antiseptic; antioxidant; volatile oil; compounds; fruits and vegetables; medicinal plants; agri-food industry; food ingredients; functional foods; nutraceuticals; food supplements; pharmaceutical products; antioxidant activity; oxidative stress; aging; anti-inflammatory activity; sustainable recovery; circular bioeconomy

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress Mechanisms and Parkinson's Disease Treatment

edited by

Juan Segura-Aguilar

submission deadline 30 Mar 2027 | 3 articles | Viewed by 6955 | Submission Open

Keywords: Parkinson’s disease; dopamine; dopamine oxidation; neuromelanin; dopaminergic neurons; antioxidants; neuroprotection; neurodegeneration; oxidative stress; protein degradation dysfunction; neuroinflammation; mitochondrial dysfunction; endoplasmic reticulum stress; alpha-synuclein oligomers; glutathione; glutathione transferase; DT-diaphorase; preclinical model for Parkinson's disease; VMAT2; dopamine transporter; tyrosine hydroxylase; dopamine-derived orto-quinones

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Advances in the Astonishing World of Phytochemicals: State of the Art for Antioxidants—3rd Edition

edited by

Antonella D'Anneo

and

Marianna Lauricella

submission deadline 30 Mar 2027 | 1 articles | Viewed by 2574 | Submission Open

Keywords: bioactive compounds; phytochemicals; antioxidant properties; oxidative and nitrosative stress; anticancer action; antimicrobial properties; anti-inflammatory actions

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Innovative Analytical Pathways: Exploring Phytochemical Profiles and Bioactivities Through Advanced Instrumentation

edited by

Igor Piotr Turkiewicz

and

Karolina Tkacz

submission deadline 30 Mar 2027 | 1 articles | Viewed by 2325 | Submission Open

Keywords: phytochemical profiling; bioactivity analysis; pharmacodynamics and pharmacokinetics of antioxidants; advanced instrumentation; natural antioxidants; extraction and isolation techniques; structural characterization; industrial applications of antioxidants; LC-MS; GC-MS; HRMS; NMR; FTIR

(This special issue belongs to the Section Extraction and Industrial Applications of Antioxidants)

Phytochemical Analysis and Evaluation of Antioxidant Properties in Medicinal Plants, 2nd Edition

edited by

Agnieszka Zgoła-Grześkowiak

Magdalena Jeszka-Skowron

Tomasz Grześkowiak

and

Robert Frankowski

submission deadline 30 Mar 2027 | Viewed by 137 | Submission Open

Keywords: antioxidant activity; phytochemicals in plants; medicinal plants; extraction; in vivo analysis; in vitro analysis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Oxidative Stress as a Therapeutic Target in Sleep Disorders

edited by

Agata Gabryelska

submission deadline 30 Mar 2027 | Viewed by 119 | Submission Open

Keywords: sleep disorders; oxidative stress; reactive oxygen species; antioxidant-based interventions; treatment strategies

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Microbiome–Antioxidant Interactions: Analytical Technologies and Functional Insights

edited by

Alina Sionkowska

Michał Złoch

and

Michalina Ehlert

submission deadline 30 Mar 2027 | Viewed by 75 | Submission Open

Keywords: microbiome–implant interface; oxidative stress; bioresponsive coatings; in situ monitoring; redox homeostasis

(This special issue belongs to the Section Natural and Synthetic Antioxidants)

Antioxidants for Skin Health—2nd Edition

edited by Rubia Casagrande

submission deadline 31 Mar 2027 | 3 articles | Viewed by 8168 | Submission Open

Keywords: skin inflammation; cytokine; skin oxidative stress; Nrf2; reduced glutathione; ultraviolet irradiation; drug delivery; flavonoid; terpenes; specialized pro-resolution lipid mediators

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Pregnant Women and Fetuses

edited by

Javier Diaz-Castro

Julio J. Ochoa Herrera

and

Jorge Moreno-Fernandez

submission deadline 31 Mar 2027 | 4 articles | Viewed by 5845 | Submission Open

Keywords: metabolic programming; oxidative stress; antioxidants; mitochondria; inflammatory signaling; reactive oxygen species; reactive nitrogen species; placenta; trace elements; nutrition; gestation; offspring; pregnancy; breastfeeding; fetus

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Roles of Oxidative Stress in Human Pathophysiology

edited by

Alexandros Georgakilas

submission deadline 31 Mar 2027 | 4 articles | Viewed by 5725 | Submission Open

Keywords: oxidative stress; reactive oxygen species; redox signaling; antioxidants; inflammation; biomarkers; human diseases; therapy; pathology; pathophysiology

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Hydrogen and Oxidative Stress: Implications for Health and Longevity

edited by

Kyu-Jae Lee

and

Cheol-Su Kim

submission deadline 31 Mar 2027 | 3 articles | Viewed by 5065 | Submission Open

Keywords: molecular hydrogen (H2); oxidative stress; redox homeostasis; selective antioxidant; reactive oxygen species (ROS); aging and longevity; mitochondrial protection; cellular resilience; hydrogen therapy; inflammation and immunity; neurodegeneration; cardiovascular health; metabolic disorders; gene regulation; translational medicine; longevity

(This special issue belongs to the Section ROS, RNS and RSS)

Oxidative Stress in Bone Metabolic Diseases

edited by Zhongbo Liu

submission deadline 31 Mar 2027 | 1 articles | Viewed by 3551 | Submission Open

Keywords: oxidative stress; bone metabolic diseases; osteoporosis; mitochondrial dysfunction; antioxidants; reactive species; osteoblast/osteoclast/osteocyte; Nrf2

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Metabolism and Mitochondrial Dysfunction in Metabolic Diseases—3rd Edition

edited by

Gina Cavaliere

and

Giovanna Trinchese

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1407 | Submission Open

Keywords: mitochondria function; oxidative processes; metabolic diseases; reactive oxygen species; therapeutic approaches; mitochondrial integrity; energy production; mitochondrial bioenergetic; metabolism; mitochondrial dynamic

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Natural Compounds in Neurogenesis, Neurodevelopment, and the Attenuation of Neurotoxicity: Insights from Animal Models

edited by

Giuseppe Montalbano

and

Kamel Mhalhel

submission deadline 31 Mar 2027 | Viewed by 471 | Submission Open

Keywords: neurogenesis; neurodevelopment; neurotoxicity; antioxidant activity; brain development

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

Oxidative Stress in Blood and Vascular Cells and Vascular Pathophysiology

edited by

Anna Pieniazek

submission deadline 31 Mar 2027 | Viewed by 360 | Submission Open

Keywords: blood; vascular cells; cellular stressors; redox homeostasis; oxidative stress; cell death; redox modulators

(This special issue belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)

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