Special Issue "Methionine Sulfoxide Reductases and Oxidative Damage"
Deadline for manuscript submissions: closed (31 August 2018).
Interests: methionine sulfoxide reductases; oxidative damage; cellular protective mechanisms
Interests: effects of methionine oxidation in proteins
Interests: oxidative damage; cancer; age-related diseases; drug development
Oxidative damage is one of the hallmarks of aging and age-related diseases. Oxidative damage occurs due to an altered balance between reactive oxygen species (ROS) production and the level of the cellular protective mechanisms. One of the cellular repair mechanisms that protects oxidative damage to proteins is the methionine sulfoxide reductase system (Msr). In mammalian cells the Msr system reduces oxidized methionine residues (Met(O)) present in proteins back to methionine. Further, the Msr system also functions to scavenge ROS by permitting methionine residues in proteins to function as catalytic antioxidants. Bacterial and animal cells lacking MsrA, and MsrA knockout mice, have been shown to be more sensitive to oxidative stress. Conversely, over-expression of MsrA renders cells more resistant to oxidative stress and MsrA overexpression in transgenic Drosophila, results in an increase in life span of the animals.
The goal of this special issue is to publish original research and review articles studying the role of the Msr system in cells. Manuscripts in all areas related to Msr will be considered including the following topics: (1) the possible role of methionine oxidation and the Msr system in age related diseases, (2) activators of the Msr enzymes, (3) the regulation of protein function by methionine oxidation and reduction, (4) Msr as a target for cancer therapy and (5) the role of Msr system in pathogen virulence.Dr. Herbert Weissbach
Dr. Nathan Brot
Dr. Shailaja Kesaraju Allani
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Methionine oxidation
- Oxidative damage
- Aging and age-related diseases
- Cellular protective mechanisms