Antioxidants and Second Messengers of Free Radicals

Dear Colleagues,

While research on pathology of oxidative stress has been complemented in recent years by intense studies on redox signaling, there is a lack of general understanding of pathophysiological roles played by reactive aldehydes like malondialdehyde, 4-hydroxynonenal, 4-hydroxyhexenal, acrolein, etc., which are considered also as “second messengers of free radicals”. Being generated mostly by lipid peroxidation, they often form bioactive adducts with macromolecules important for pathophysiology of living cells, thus mimicking the effects of ROS even in the absence of severe oxidative stress. We lack especially understanding on the complex effects of antioxidants that might be active in regulation of toxic and/or hormetic effects of reactive aldehydes.

Therefore, this Special Issue will publish original research papers and reviews on complex aspects of reactive aldehydes and their macromolecular adducts (especially with proteins and nucleic acids) generated during lipid peroxidation and their interference with natural and synthetic antioxidants in physiology of cell and in pathophysiology of various diseases studied by modern bioanalytical methods applied in translational and clinical medicine.

Prof. Dr. Neven Zarkovic
Guest Editor

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