Special Issue "Vitamin C: Current Concepts in Human Physiology"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (31 January 2018)
A printed edition of this Special Issue is available here.
Prof. Dr. Ramesh Natarajan
Division of Pulmonary Disease and Critical Care Medicine, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, USA
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Interests: sepsis; acute lung injury; hemorrhagic shock and trauma; transplantation medicine; hemostasis and thrombosis; ischemia-reperfusion; inflammation; wound healing; coagulation; gene regulation; nitric oxide; molecular biology; cell biology
Vitamin C is synthesized by almost all animals. However, for humans, it is a vitamin that needs constant replenishment in the diet. While its role as an anti-oxidant and for preventing scurvy have been known for a long time, novel functions and unrecognized associations continue to be identified for this enigmatic molecule. In the past decade, new details have emerged regarding differences in its uptake by oral and intravenous modes. While vitamin C deficiency remains largely unknown and poorly addressed in many segments of the population, novel pharmacological roles for high dose intravenous vitamin C in many disease states have now been postulated and investigated. This has shifted its role in health and disease from the long perceived notion as merely an anti-oxidant, to a pleiotropic molecule with a broad anti-inflammatory, epigenetic and anti-cancer profile.
This Special Issue will publish original research papers and reviews on vitamin C metabolism and function that relate to the following topics: Unrecognized nutritional deficiency in disease; understanding its role in the modulation of inflammation and immunity; therapeutic applications of pharmacological ascorbate in disease; epigenetic modulation of disease by vitamin C; and the emerging role of vitamin C as a pleiotropic modulator of critical care illness and cancer.
Prof. Dr. Ramesh Natarajan
Dr. Anitra Carr
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 550 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Gene regulation
- Critical care illness
- Cardiovascular diseases
- Quality of life