Dietary Antioxidant Compounds and Liver Health: Pharmacological Activities and Molecular Mechanisms

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 25 September 2025 | Viewed by 1134

Special Issue Editors


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Guest Editor
Institute for Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Mexico
Interests: liver diseases; pharmacology; drugs; antioxidants

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Guest Editor Assistant
Institute of Molecular Biology in Medicine and Gene Therapy, Department of Molecular Biology and Genomics, University Center of Health Sciences, University of Guadalajara, Guadalajara 44340, Mexico
Interests: liver disease; obesity; metabolism; cardiovascular disease

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Guest Editor Assistant
Department of Molecular Biology and Genomics, Institute of Molecular Biology in Medicine and Gene Therapy, CUCS, University of Guadalajara, Guadalajara 44340, Mexico
Interests: pharmacology; liver diseases; drugs; metabolic diseases

Special Issue Information

Dear Colleagues,

Obesity is a multifactorial disorder with a high global prevalence characterized by excessive visceral fat accumulation accompanied by hormonal alterations, increased oxidant and inflammatory response, and modifications in endothelial function. These alterations stimulate other mechanisms that contribute to various pathophysiological processes in the heart, liver, pancreas, kidneys, digestive system, nervous system, etc.

The first-line strategies for managing this disease are to limit energy intake from total fat and sugars, increase the consumption of fruits and vegetables, legumes, whole grains, and nuts, and perform rigorous, high-intensity, and frequent physical activity.

Considerable research has focused on finding foods that restore metabolic balance more efficiently. Natural foods rich in polyphenols, fiber, vitamins, minerals, polyunsaturated fatty acids, and anthocyanins can have significant effects on restoring homeostasis and particularly on restoring liver health.

In this Special Issue, we invite researchers and working groups to submit original, basic, clinical, or translational research articles and/or novel specialized reviews that address molecular, genetic, and/or epigenetic aspects, including findings in in vivo models, in vitro studies, in silico studies, and clinical trials, which address the relationship between the consumption of antioxidant compounds and functional foods and the restoration of liver function.

Prof. Dr. Juan Socorro Armendariz-Borunda
Guest Editor

Prof. Dr. Marina Galicia-Moreno
Dr. Hugo Christian Monroy-Ramirez
Guest Editor Assistants

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • liver
  • oxidative stress
  • antioxidants
  • natural foods
  • MAFLD
  • NAFLD
  • obesity
  • liver function
  • hepatitis

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Published Papers (1 paper)

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Review

28 pages, 1017 KB  
Review
Naringin and Naringenin in Liver Health: A Review of Molecular and Epigenetic Mechanisms and Emerging Therapeutic Strategies
by Roberto Flores-Peña, Hugo Christian Monroy-Ramirez, Fernando Caloca-Camarena, Scarlet Arceo-Orozco, Jorge Alejandro Salto-Sevilla, Marina Galicia-Moreno and Juan Armendariz-Borunda
Antioxidants 2025, 14(8), 979; https://doi.org/10.3390/antiox14080979 - 10 Aug 2025
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Abstract
Liver diseases have become a significant global health concern, driving increased interest in naturally occurring compounds as adjunctive treatments for managing these conditions. Flavonoids, a class of natural polyphenols found in plants and fruits, offer a broad spectrum of potential health benefits due [...] Read more.
Liver diseases have become a significant global health concern, driving increased interest in naturally occurring compounds as adjunctive treatments for managing these conditions. Flavonoids, a class of natural polyphenols found in plants and fruits, offer a broad spectrum of potential health benefits due to their applications in nutraceuticals, pharmaceuticals, and cosmetics. Among them, naringin (NARI) and naringenin (NAR), which are abundant in citrus fruits, have attracted considerable attention. Numerous studies have investigated the therapeutic effects of NARI and NAR across different stages of liver disease. This review highlights recent research on the impact of these flavonoids in alcohol-related liver disease and metabolic dysfunction-associated fatty liver disease (MASLD). It also explores the molecular mechanisms and epigenetic modifications through which NARI and NAR contribute to preventing liver disease progression. Finally, this work discusses recent progresses and future perspectives, emphasizing the role of innovative nanocarriers, nanoparticles, and drug delivery strategies in enhancing the efficacy and bioavailability of these promising compounds to improve liver health. Full article
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