Antioxidant Systems, Transcription Factors and Non-Coding RNAs

Dear Colleagues,

Antioxidant systems protect against perturbation of the intracellular redox status due to high levels of reactive oxygen/nitrogen species (ROS/RNS). Accordingly, dysfunction in these systems can trigger oxidative damage and foster diseases like neurodegeneration, senescence/aging, cancer, and different types of cardiac and kidney disorders. ROS/RNS-sensitive transcription factors closely associate with defense programs, since they can engage downstream enzymatic and non-enzymatic antioxidant pathways to restore redox balance. These defense processes are often dynamically interlinked with post-transcriptional regulatory mechanisms mediated by non-coding RNAs, mainly microRNAs, long-non-coding RNAs, and circular RNAs, also involved in epigenetic regulatory events. Therefore, the interplay between transcription factors and non-coding RNAs is found to be important within the antioxidant response, and ongoing research is focused on these redox regulators.

This Special Issue aims to collect original research articles, communications, and reviews defining novel non-coding RNA-mediated regulatory mechanisms that influence the activities of redox transcription factors and their importance in the antioxidant defense network. Exploring these characteristics may facilitate the development of novel non-coding RNA therapeutics, aimed at governing healthy living.

Dr. Raffaella Faraonio
Guest Editor

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