Small Molecule Approaches to Modulating Oxidative Stress Responses
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: 29 August 2025 | Viewed by 595
Special Issue Editor
Interests: structural biology; protein structure determination; solution nmr; protein-ligand interaction; intrinsically disordered proteins; protein domain
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress disrupts homeostasis, impairs health, and shortens the lifespan of both humans and eukaryotic unicellular organisms such as yeast and plants. Reactive oxygen species can damage lipid bilayers, proteins, and nucleic acids, disrupting intracellular redox signaling both directly and indirectly. Therefore, small-molecule antioxidants are effective in repairing or preventing the physiological imbalance caused by reactive oxygen species.
Naturally occurring antioxidants such as flavonoids and polyphenols could be used as medicinal components in traditional medicines and disease-preventive ingredients in health foods. However, their pharmacological actions are diverse and often do not correlate directly with their redox potential. For example, resveratrol is an antioxidant that exerts complex effects by interacting with SIRT1, cyclooxygenase, and NF-κB. Similarly, baicalin, a flavonoid, has been shown to bind directly to the tight junction protein ZO-1.
We believe that the synergy between the unique biochemical properties, physiological activity, and antioxidant properties of naturally occurring antioxidants is of paramount importance. Therefore, this Special Issue welcomes the submission of original research papers, proof-of-concept articles, experiments leading to practical applications in pharmaceuticals, cosmetics, and health foods. We also welcome comprehensive review articles that summarize recent insights from novel perspectives. We are particularly interested in submissions related to intracellular oxidative stress, the unique pharmacological functions of small antioxidants, as well as the modulation of signal transduction. Additionally, we welcome studies regarding the production, quality control, and use of plant extracts rich in antioxidants, as well as the application of traditional medicine and health foods containing antioxidants as major components.
Prof. Dr. Hidekazu Hiroaki
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- natural products
- nutraceuticals
- antioxidants
- polyphenols
- flavonoids
- barrier function
- cellular senescence
- inflammation
- DNA damage
- regeneration
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