Oxidative Stress and Lysosomal Function in Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 29 August 2025 | Viewed by 3173
Special Issue Editors
Interests: lysosomal dysfunction; lysosomal storage disorders; cholesterol; lipids; lipid intracellular transport; cholesterol neurodegenerative diseases; liver diseases
Interests: lysosomal dysfunction; neurobiology; synaptic plasticity; neurodegenerative diseases
Special Issue Information
Dear Colleagues,
Lysosomes are the cellular center for degradation and recycling of a variety of biological macromolecules. Moreover, they are essential for autophagy and fulfill relevant functions as a metabolic signaling platform that intersects with multiple pathways. In addition, lysosomes dynamically and strongly communicate with other key organelles involved in cellular metabolism, such as the endoplasmic reticulum and mitochondria.
Therefore, lysosome functionality has significant implications for health and disease. In this context, alterations in lysosome homeostasis are associated with diverse disorders which include common diseases, such as obesity, liver steatosis, Alzheimer's, and Parkinson's, and less frequent ones, such as lysosomal storage diseases. Interestingly, mounting evidence shows that increased oxidative stress induces lysosome damage, potentially compromising its functionality and therefore several processes in which this organelle participates, including autophagy.
We invite you to submit to this Special Issue that will bring together current research relating oxidative stress to lysosome function in health and disease, including both in vitro and in vivo studies. Your latest research findings or review articles are also welcome.
We look forward to your contributions.
Dr. Silvana M. Zanlungo
Dr. Alejandra R. Álvarez
Guest Editors
Manuscript Submission Information
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Keywords
- lysosome
- lysosomal dysfunction
- lysosome homeostasis
- autophagy
- oxidative stress
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