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Antioxidants
Special Issues
Oxidative Stress and Lysosomal Function in Health and Disease
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Oxidative Stress and Lysosomal Function in Health and Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: 29 August 2025 | Viewed by 3808

Special Issue Editors

Dr. Silvana M. Zanlungo

E-Mail Website
Guest Editor
Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330033, Chile
Interests: lysosomal dysfunction; lysosomal storage disorders; cholesterol; lipids; lipid intracellular transport; cholesterol neurodegenerative diseases; liver diseases
Dr. Alejandra R. Álvarez

E-Mail Website
Guest Editor
Cell Signaling Laboratory, Department of Cell and Molecular Biology, Biological Sciences Faculty, Millennium Institute on Immunology and Immunotherapy, Pontificia Universidad Católica de Chile, Santiago 8331150, Chile
Interests: lysosomal dysfunction; neurobiology; synaptic plasticity; neurodegenerative diseases

Special Issue Information

Dear Colleagues,

Lysosomes are the cellular center for degradation and recycling of a variety of biological macromolecules. Moreover, they are essential for autophagy and fulfill relevant functions as a metabolic signaling platform that intersects with multiple pathways. In addition, lysosomes dynamically and strongly communicate with other key organelles involved in cellular metabolism, such as the endoplasmic reticulum and mitochondria.

Therefore, lysosome functionality has significant implications for health and disease. In this context, alterations in lysosome homeostasis are associated with diverse disorders which include common diseases, such as obesity, liver steatosis, Alzheimer's, and Parkinson's, and less frequent ones, such as lysosomal storage diseases. Interestingly, mounting evidence shows that increased oxidative stress induces lysosome damage, potentially compromising its functionality and therefore several processes in which this organelle participates, including autophagy.

We invite you to submit to this Special Issue that will bring together current research relating oxidative stress to lysosome function in health and disease, including both in vitro and in vivo studies. Your latest research findings or review articles are also welcome.

We look forward to your contributions.

Dr. Silvana M. Zanlungo
Dr. Alejandra R. Álvarez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lysosome
  • lysosomal dysfunction
  • lysosome homeostasis
  • autophagy
  • oxidative stress

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Published Papers (3 papers)

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18 pages, 2600 KiB  
Article
c-Abl/TFEB Pathway Activation as a Common Pathogenic Mechanism in Lysosomal Storage Diseases: Therapeutic Potential of c-Abl Inhibitors
by Miguel V. Guerra, Juan Castro, Antonio Moreno, Elisa Balboa, Juan J. Marugan, Alejandra R. Alvarez and Silvana Zanlungo
Antioxidants 2025, 14(5), 611; https://doi.org/10.3390/antiox14050611 - 20 May 2025
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Abstract
Lysosomal storage diseases (LSDs) are characterized by the accumulation of undegraded substrates within lysosomes, often associated with oxidative stress and impaired lysosomal function. In this study, we investigate the role of the c-Abl/TFEB pathway in different LSDs: Gaucher, Niemann-Pick type A (NPA), and [...] Read more.
Lysosomal storage diseases (LSDs) are characterized by the accumulation of undegraded substrates within lysosomes, often associated with oxidative stress and impaired lysosomal function. In this study, we investigate the role of the c-Abl/TFEB pathway in different LSDs: Gaucher, Niemann-Pick type A (NPA), and Niemann-Pick type C (NPC). Our findings identify c-Abl activation (p-c-Abl) as a common pathogenic mechanism in these disorders. We demonstrate that c-Abl phosphorylates TFEB at Tyr173, leading to its cytoplasmic retention. Using pharmacological models of Gaucher, NPA and NPC in SH-SY5Y neuronal cells and HeLa cells, we assess the effects of the c-Abl inhibitors Imatinib and Neurotinib, as well as the antioxidant α-Tocopherol (α-TOH), on TFEB nuclear translocation and p-c-Abl protein levels. Additionally, we explore the effects of c-Abl inhibitors in cholesterol accumulation in LSDs neuronal models. Our results show that treatment with c-Abl inhibitors or α-TOH promotes TFEB nuclear translocation, enhances lysosomal clearance, and reduces cholesterol accumulation in all three LSD models. These findings highlight the c-Abl/TFEB pathway as a potential therapeutic target for LSDs and potentially other neurodegenerative disorders associated with lysosomal dysfunction. Full article
(This article belongs to the Special Issue Oxidative Stress and Lysosomal Function in Health and Disease)
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Review

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20 pages, 2030 KiB  
Review
Targeting Lysosomal Dysfunction and Oxidative Stress in Age-Related Macular Degeneration
by Ana S. Falcão, Margarida L. Pedro, Sandra Tenreiro and Miguel C. Seabra
Antioxidants 2025, 14(5), 596; https://doi.org/10.3390/antiox14050596 - 16 May 2025
Viewed by 163
Abstract
Age-related macular degeneration (AMD) is the leading cause of vision loss in the Western world, and it currently lacks effective therapy. It is believed that AMD initiates in the aged retinal pigment epithelium (RPE), which presents lysosomal dysfunction and oxidative stress (OxS) that [...] Read more.
Age-related macular degeneration (AMD) is the leading cause of vision loss in the Western world, and it currently lacks effective therapy. It is believed that AMD initiates in the aged retinal pigment epithelium (RPE), which presents lysosomal dysfunction and oxidative stress (OxS) that ultimately leads to RPE damage and AMD progression. AMD is a complex pathology, so multitarget treatments are required to act on different pathways, presenting several challenges. In this review, we discuss the current knowledge on the pathogenesis of this disease, focusing mainly on lysosomal dysfunction and OxS. Because transcription factors regulate homeostasis, the transcription factor EB (TFEB), which controls lysosomal function and biogenesis, and the nuclear factor erythroid 2-related factor 2 (NRF2), which manages OxS, have been proposed as promising targets for disease intervention. Finally, we discuss the interplay of these pathways for a potential synergistic effect on AMD-targeted therapies, as they could change the course of today’s available treatments for AMD. Full article
(This article belongs to the Special Issue Oxidative Stress and Lysosomal Function in Health and Disease)
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28 pages, 1523 KiB  
Review
Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease
by Szilvia Kiraly, Jack Stanley and Emily R. Eden
Antioxidants 2025, 14(2), 125; https://doi.org/10.3390/antiox14020125 - 22 Jan 2025
Viewed by 2735
Abstract
The perception of lysosomes and mitochondria as entirely separate and independent entities that degrade material and produce ATP, respectively, has been challenged in recent years as not only more complex roles for both organelles, but also an unanticipated level of interdependence are being [...] Read more.
The perception of lysosomes and mitochondria as entirely separate and independent entities that degrade material and produce ATP, respectively, has been challenged in recent years as not only more complex roles for both organelles, but also an unanticipated level of interdependence are being uncovered. Coupled lysosome and mitochondrial function and dysfunction involve complex crosstalk between the two organelles which goes beyond mitochondrial quality control and lysosome-mediated clearance of damaged mitochondria through mitophagy. Our understanding of crosstalk between these two essential metabolic organelles has been transformed by major advances in the field of membrane contact sites biology. We now know that membrane contact sites between lysosomes and mitochondria play central roles in inter-organelle communication. This importance of mitochondria–lysosome contacts (MLCs) in cellular homeostasis, evinced by the growing number of diseases that have been associated with their dysregulation, is starting to be appreciated. How MLCs are regulated and how their coordination with other pathways of lysosome–mitochondria crosstalk is achieved are the subjects of ongoing scrutiny, but this review explores the current understanding of the complex crosstalk governing the function of the two organelles and its impact on cellular stress and disease. Full article
(This article belongs to the Special Issue Oxidative Stress and Lysosomal Function in Health and Disease)
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