Advances in Oxidoreductases

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".

Deadline for manuscript submissions: 10 March 2026 | Viewed by 1125

Special Issue Editor


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Guest Editor
College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea
Interests: methionine oxidation; methionine restriction; aging; methionine sulfoxide reductase; redox biosensors
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Special Issue Information

Dear Colleagues,

Oxidoreductases are enzymes that catalyze redox reactions, playing vital roles in metabolism, signaling, disease regulation, redox balance, tumor microenvironment modulation, and inflammation. Recent advancements in oxidoreductase research have greatly influenced fields like cancer therapy, immunology, and drug development, expanding our understanding of their involvement in cancer, inflammation, and metabolic disorders. Targeting specific oxidoreductases—such as MsrB1, TrxR, and NOX—holds promising potential for developing novel therapeutic strategies.

Despite our long-term study of oxidoreductases, they continue to reveal new functions and roles. Additionally, advancements in engineering technologies have facilitated their integration into innovative fields such as biosensors, expanding their research applications. This Special Issue aims to provide a platform for discussing and reviewing the latest research findings and developments in oxidoreductase-related studies.

We invite you to submit your latest research or a review article to this Special Issue, focusing on the function, regulation, and therapeutic potential of oxidoreductases, as well as their applications in fields such as redox biology, disease management, drug development, and biosensor technology.

Dr. Byung Cheon Lee
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • oxidoreductase
  • redox enzyme
  • metabolic regulation
  • signaling
  • cancer
  • immune regulation

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Published Papers (1 paper)

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Review

20 pages, 3618 KB  
Review
Superoxide Dismutases in Immune Regulation and Infectious Diseases
by Tong Liu, Jiajin Shang and Qijun Chen
Antioxidants 2025, 14(7), 809; https://doi.org/10.3390/antiox14070809 - 30 Jun 2025
Cited by 1 | Viewed by 927
Abstract
Superoxide dismutases (SODs) maintain redox homeostasis through the catalytic dismutation of superoxide anions, thereby affording protection to organisms against oxidative damage. The SOD family, encompassing Cu/Zn-SOD, Mn-SOD, Fe-SOD, and Ni-SOD, exhibits structural diversity and constitutes a multilevel antioxidant defense system with discrete subcellular [...] Read more.
Superoxide dismutases (SODs) maintain redox homeostasis through the catalytic dismutation of superoxide anions, thereby affording protection to organisms against oxidative damage. The SOD family, encompassing Cu/Zn-SOD, Mn-SOD, Fe-SOD, and Ni-SOD, exhibits structural diversity and constitutes a multilevel antioxidant defense system with discrete subcellular localizations. Beyond their antioxidant functions, SODs also function as immunomodulatory proteins, regulating the maturation, proliferation, and differentiation of immune cells. They further fulfill a crucial role in host responses to parasitic infections. The current review synthesizes and critically evaluates extant research to comprehensively delineate the molecular architecture of SODs, their intricate post-translational modification (PTM) networks, and their dual regulatory mechanisms at the interface of immunomodulation and pathological processes. This review establishes a critical framework for elucidating the biological significance of redox homeostasis maintenance. Full article
(This article belongs to the Special Issue Advances in Oxidoreductases)
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