Mitochondrial Oxidative Stress and Inflammation

Dear Colleagues,

The main source of reactive oxygen species (ROS) responsible for oxidative stress in cells is mitochondrial respiration. When the excessive formation of ROS overwhelms the intrinsic antioxidant, a condition known as oxidative stress occurs. ROS can have damaging effects on proteins, lipids, and DNA, disrupting mitochondrial function and causing the subsequent development of various disease processes. Mitochondrial oxidative stress has been implicated in a wide variety of diseases including Alzheimer’s disease (AD), cardiovascular disease, and autoimmune type 1 diabetes. Research also suggests that mitochondria play an important role in pro-inflammatory signaling. Likewise, pro-inflammatory mediators may also alter mitochondrial function. Both processes increase mitochondrial oxidative stress, promoting an inflammatory cycle.

As Guest Editors, we invite you to contribute to this Special Issue, where the focus of which will be on the role of mitochondrial oxidative stress and/or inflammation in disease progression and during therapeutic interventions.

Prof. Dr. Aldrin V. Gomes
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.