Oxidative Stress in Chronic Diseases: A Focus on Rheumatoid Arthritis

A special issue of Antioxidants (ISSN 2076-3921).

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 5578

Special Issue Editors


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Department of Internal Medicine, University of Londrina, Londrina, Paraná, Brazil
Interests: oxidative stress; inflammation; immunoinflammatory disorders; metabolic disorders; nutritional intervention
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Guest Editor
Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN, USA
Interests: oxidative stress; inflammation; plastic surgery; reconstructive surgery

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Guest Editor
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Interests: oxidative stress; antioxidants; inflammation; autoimmune disorders; mitochondria
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Special Issue Information

Dear Colleagues,

Reactive oxygen species (ROS) are products of cellular metabolism that, in controlled quantities, modulate several physiological aspects of cell function and are required for signaling pathways. Nonetheless, when excessive ROS production occurs or when their elimination by antioxidant mechanisms is impaired, they may accumulate and become pathogenic, a condition known as oxidative stress. Oxidative stress plays an important role in the development and exacerbation of several inflammatory, chronic, and autoimmune diseases. Recent advances in the understanding of the pathological action of oxidative species, as well as promising findings involving the prevention and even treatment of immunoinflammatory diseases with antioxidant therapies, have highlighted the potential of redox homeostasis for the maintenance of physiological functions and the prevention of numerous redox-dependent pathologies.

The aim of this Special Issue is to continue to explore the impact of ROS on cellular function, emphasizing the role of oxidative stress in inflammatory and autoimmune conditions. This Special Issue aims to present updated research on the relationship between oxidative stress and the development or exacerbation of chronic diseases, particularly inflammatory rheumatic disorders such as rheumatoid arthritis. This Special Issue will consider in vitro and in vivo studies investigating molecular mechanisms and the effects of antioxidant therapies on these conditions, highlighting the potential of maintaining redox homeostasis for preventing and managing redox-dependent pathologies. Both original and review articles are welcome.

Dr. Isaias Dichi
Dr. Alexandre Meira Pazelli
Dr. Bruna Miglioranza Scavuzzi
Guest Editors

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Keywords

  • rheumatic disorders
  • autoimmune conditions
  • oxidative stress
  • inflammation
  • redox state
  • antioxidant therapy

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Published Papers (2 papers)

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Review

41 pages, 2908 KiB  
Review
Transcription Factor Blimp-1: A Central Regulator of Oxidative Stress and Metabolic Reprogramming in Chronic Inflammatory Diseases
by Aline Yen Ling Wang, Ana Elena Aviña, Yen-Yu Liu, Yun-Ching Chang and Huang-Kai Kao
Antioxidants 2025, 14(2), 183; https://doi.org/10.3390/antiox14020183 - 4 Feb 2025
Viewed by 1132
Abstract
B-lymphocyte-induced maturation protein 1 (Blimp-1) is a transcription factor that, among other functions, modulates metabolism and helps to regulate antioxidant pathways, which is important in the context of chronic inflammatory diseases like diabetes, cardiovascular disease, and autoimmune disease. In immune cell function, Blimp-1 [...] Read more.
B-lymphocyte-induced maturation protein 1 (Blimp-1) is a transcription factor that, among other functions, modulates metabolism and helps to regulate antioxidant pathways, which is important in the context of chronic inflammatory diseases like diabetes, cardiovascular disease, and autoimmune disease. In immune cell function, Blimp-1 has a modulatory role in the orchestration of metabolic reprogramming and as a promoter of anti-inflammatory cytokines, including IL-10, responsible for modulating oxidative stress and immune homeostasis. Moreover, Blimp-1 also modulates key metabolic aspects, such as glycolysis and fatty acid oxidation, which regulate reactive oxygen species levels, as well as tissue protection. This review depicts Blimp-1 as an important regulator of antioxidant defenses and anti-inflammation and suggests that the protein could serve as a therapeutic target in chronic inflammatory and metabolic dysregulation conditions. The modulation of Blimp-1 in diseases such as diabetic coronary heart disease and atherosclerosis could alleviate oxidative stress, augment the protection of tissues, and improve disease outcomes. The therapeutic potential for the development of new treatments for these chronic conditions lies in the synergy between the regulation of Blimp-1 and antioxidant therapies, which are future directions that may be pursued. This review emphasizes Blimp-1’s emerging importance as a novel regulator in the pathogenesis of inflammatory diseases, providing new opportunities for therapeutic intervention. Full article
(This article belongs to the Special Issue Oxidative Stress in Chronic Diseases: A Focus on Rheumatoid Arthritis)
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56 pages, 4295 KiB  
Review
Therapeutic Potential of Plant-Derived Compounds and Plant Extracts in Rheumatoid Arthritis—Comprehensive Review
by Mateusz Kciuk, Anjali Garg, Manni Rohilla, Rishabh Chaudhary, Sanchit Dhankhar, Sachin Dhiman, Seema Bansal, Monika Saini, Thakur Gurjeet Singh, Samrat Chauhan, Somdutt Mujwar, Adrianna Gielecińska and Renata Kontek
Antioxidants 2024, 13(7), 775; https://doi.org/10.3390/antiox13070775 - 27 Jun 2024
Cited by 5 | Viewed by 3794
Abstract
Rheumatoid arthritis (RA) is a persistent autoimmune disorder that is characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness is often restricted and may be linked to unfavorable side effects. Consequently, there has been growing interest [...] Read more.
Rheumatoid arthritis (RA) is a persistent autoimmune disorder that is characterized by joint inflammation, discomfort, and impairment. Despite the existence of several therapeutic approaches, their effectiveness is often restricted and may be linked to unfavorable side effects. Consequently, there has been growing interest in investigating naturally derived compounds as plausible therapeutic agents for RA disease. The objective of this review is to summarize the existing preclinical and clinical evidence regarding the efficacy of naturally extracted compounds and plant extracts in the treatment of RA, focusing on their anti-inflammatory, anti-oxidative, and immunomodulatory properties. Some of the problems with using natural chemicals are the uneven quality of commercially available preparations and the poor bioavailability of these compounds. Future investigations should focus on improving the formulations, conducting thorough clinical trials, and exploring different techniques to fully utilize the intrinsic potential of naturally derived chemicals in treating RA. Full article
(This article belongs to the Special Issue Oxidative Stress in Chronic Diseases: A Focus on Rheumatoid Arthritis)
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