Lipid Peroxidation in Physiology and Chronic Inflammatory Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 505
Special Issue Editor
Interests: cellular and clinical immunology; allergy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Lipid peroxidation is a fundamental biological process that has both physiological and pathological implications. Under controlled conditions, lipid peroxidation products act as signaling molecules involved in cellular homeostasis, immune responses, and redox regulation. However, excessive oxidative stress disrupts this balance, leading to the accumulation of reactive lipid species that drive chronic inflammation, thus causing tissue damage. The imbalance between oxidative insult and antioxidant defenses plays a crucial role in the pathogenesis of various conditions, including cardiovascular diseases, neurodegenerative disorders, cutaneous diseases, metabolic syndrome, and autoimmune diseases.
This Special Issue aims to explore both the beneficial and detrimental aspects of lipid peroxidation, particularly its contribution to chronic inflammatory diseases.
We welcome original research articles, reviews, and clinical studies that investigate the following:
- The physiological roles of lipid peroxidation-derived molecules in cellular signaling and homeostasis.
- The molecular mechanisms linking excessive lipid peroxidation to chronic inflammation.
- Biomarkers of lipid peroxidation as potential diagnostic or prognostic tools.
- The role of antioxidant defense systems in maintaining lipid peroxidation homeostasis.
- Therapeutic strategies targeting lipid peroxidation to mitigate inflammation and disease progression.
- The crosstalk between lipid peroxidation, immune responses, and metabolic dysfunction.
By gathering cutting-edge research from various disciplines—including biochemistry, molecular biology, pharmacology, and clinical sciences—this Special Issue will provide a comprehensive understanding of lipid peroxidation's dual role in physiology and pathology, with implications for the development of novel therapeutic strategies.
Prof. Dr. Mario Di Gioacchino
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lipid peroxidation
- oxidative stress
- chronic inflammation
- antioxidants
- reactive lipid species
- inflammatory signaling
- redox biology
- lipid mediators
- disease pathogenesis
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