Exploring Biomarkers of Oxidative Stress in Health and Disease

Dear Colleagues,

For forty decades, the concept of oxidative stress has remained an important focus of interest in biomedical research, and limiting oxidative stress intensity became a cutting-edge therapeutic goal of pharmaceutical research. This imbalance in redox homeostasis and the consequent oxidative damage accumulation in macromolecules has been considered as a cause of cellular impairment, being associated with numerous risk factors of several diseases, with age-related pathological conditions as well as with normal ageing. This continuous interest in oxidative stress is also highlighted by the development of new molecules, such as dimethyl fumarate, that act through signalling pathways modulating redox homeostasis (e.g., Nrf2) and that are used as targeted therapy against severe diseases (multiple sclerosis).

In this Special Issue, the main emphasis will be on the relevance of oxidative stress biomarkers assessed under specific physiopathological/toxicological situations such as metabolic dysregulations (dyslipidaemia, chronic hyperglycaemia, hyperinsulinaemia, hyperuricaemia), intoxications, or environmental exposure to harmful agents (cigarette smoking, pollutants, UV and ionizing irradiation). This approach is necessary since redox imbalance pathways and oxidative stress biomarkers are studied extensively and considered as new targets in prevention, diagnosis and therapy for cardiometabolic diseases (cardiovascular diseases, type 2 diabetes mellitus, metabolic syndrome and obesity), neurodegenerative disorders, cancer, inflammation, and also as candidate biomarkers in evaluating the human biological age.

We invite investigators to contribute with critical reviews and original research articles concerning the most recent advances in the study of oxidative stress biomarkers which emerged as relevant tools for the investigation and diagnosis of oxidopathies and for monitoring the efficiency of antioxidant therapies in clinical samples or experimental models.

Potential topics include, but are not limited to, the following:

• Lipid and lipoprotein oxidation markers;
• Protein oxidation and glycoxidation;
• Protein carbonylation, nitration and chlorination;
• Protein glutathionylation;
• DNA/RNA oxidative damage;
• Enzymatic and non-enzymatic antioxidant defence;
• Antioxidant status/properties;
• Redox cellular/molecular pathways.

Prof. Dr. Daniela Gradinaru
Prof. Dr. Denisa Marilena Margină
Guest Editors

Manuscript Submission Information

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• oxidative and nitrosative stress
• AGEs—advanced glycation end-products
• lipid peroxidation
• nitrotyrosine
• glutathione
• 8-oxo-2'-deoxyguanosine
• inflammation
• cardiometabolic risk
• cancer
• neurodegeneration
• nanoparticles
• xenobiotic
• antioxidant
• ageing
• advanced therapies