Submit to Antioxidants Review for Antioxidants Propose a Special Issue

Journal Menu

Journal Browser

Role of Natural Antioxidants on Neuroprotection

Editors
Special Issue Information
Keywords
Benefits of Publishing in a Special Issue
Published Papers

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 April 2026) | Viewed by 37864

Share This Special Issue

Editors

Dr. Mercedes Villacampa

E-Mail Website
Guest Editor

The Organic and Medicinal Chemistry Section in the Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense of Madrid, 28040 Madrid, Spain
Interests: neurodegenerative diseases; PROTACs; mechanochemistry
Special Issues, Collections and Topics in MDPI journals

Dr. José Carlos Menéndez

E-Mail Website
Guest Editor

The Organic and Medicinal Chemistry Section in the Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense of Madrid, 28040 Madrid, Spain
Interests: neurodegenerative diseases; drug discovery; sustainable synthesis
Special Issues, Collections and Topics in MDPI journals

Dr. Ángel Cores

E-Mail Website
Guest Editor

The Organic and Medicinal Chemistry Section in the Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense of Madrid, 28040 Madrid, Spain
Interests: neurodegenerative diseases; medicinal chemistry; pseudo-natural products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The quest for effective neuroprotective strategies has led to significant interest in natural antioxidants due to their potential to combat oxidative stress, a major contributor to neurodegenerative diseases. Oxidative stress results from an imbalance between free radicals and antioxidants in the body, leading to neuronal damage and the progression of conditions such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis (ALS). Natural antioxidants, including polyphenols, flavonoids, certain vitamins, and carotenoids, have shown promise in mitigating oxidative damage and enhancing brain health. These compounds, derived from fruits, vegetables, and other plant sources, have been extensively studied for their ability to neutralize free radicals, induce the secondary antioxidant response, reduce inflammation, and modulate the signaling pathways involved in neurodegeneration.

This Special Issue, "Role of Natural Antioxidants on Neuroprotection", aims to gather cutting-edge research and comprehensive reviews on the neuroprotective effects of natural antioxidants. We invite researchers to contribute original studies and review articles that explore the mechanisms of action, efficacy, and therapeutic potential of these bioactive agents in preventing and treating neurodegenerative diseases. By compiling this body of work, we seek to advance our understanding of how natural antioxidants can be harnessed to protect neural health and improve the quality of life for individuals affected by neurodegenerative conditions.

Dr. Mercedes Villacampa
Dr. José Carlos Menéndez
Dr. Ángel Cores
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

drug design
polyphenols
oxidative stress
Nrf2 induction
neuroinflammation
neurodegenerative diseases

Benefits of Publishing in a Special Issue

Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (9 papers)

Download All Papers

Order results

Result details

Show export options Show export options

Select all

Export citation of selected articles as:

Research

Jump to: Review

20 pages, 3039 KB

Open AccessArticle

Skimmianine Pretreatment Attenuates Cerebellar Neuroinflammation and Myelin Injury Following Experimental Cerebral Ischemia–Reperfusion

by Fırat Aşır, Ebru Gökalp Özkorkmaz, Murat Yalçın, Fırat Şahin and Tuğcan Korak

Antioxidants 2026, 15(6), 743; https://doi.org/10.3390/antiox15060743 - 11 Jun 2026

Cited by 1 | Viewed by 403

Abstract

Objective: Cerebral ischemia/reperfusion (I/R) injury triggers oxidative stress, neuroinflammation, neuronal degeneration, and white matter damage not only in directly affected cerebral regions but also in remote brain areas such as the cerebellum. Skimmianine, a naturally occurring furoquinoline alkaloid, has been reported to possess antioxidant and anti-inflammatory properties. This study investigated the protective effects of skimmianine pretreatment against secondary cerebellar injury following experimental cerebral I/R. Materials and Methods: Thirty-two female Wistar rats were randomly assigned to sham, Skimmianine, I/R, and I/R + Skimmianine groups (n = 8/group). Cerebral I/R was induced by transient middle cerebral artery occlusion for 60 min followed by 23 h reperfusion. Skimmianine (40 mg/kg/day, intraperitoneally) was administered for 14 days before ischemia induction. Oxidative stress markers, neuroinflammatory mediators, histopathological alterations, behavioral outcomes, and ultrastructural changes were evaluated. In addition, network pharmacology and molecular docking analyses were performed to explore potential molecular mechanisms. Results: Cerebral I/R significantly decreased TAS levels compared with sham (0.89 ± 0.15 vs. 1.52 ± 0.18 mmol Trolox Eq/L) and increased TOS (15.60 ± 3.03 vs. 6.80 ± 1.41 µmol H₂O₂ Eq/L), OSI (17.48 ± 0.50 vs. 4.43 ± 0.47), TNF-α (68.4 ± 10.2 vs. 18.6 ± 4.4 pg/mL), Iba1 (41.3 ± 9.7 vs. 11.7 ± 1.6 pg/mL), and GFAP levels (334.5 ± 12.5 vs. 87.7 ± 9.5 ng/mL; all p < 0.001). I/R also impaired motor performance, as shown by increased beam crossing time (11.7 ± 2.2 vs. 4.8 ± 0.7 s) and grid foot fault rate (18.6 ± 4.0% vs. 3.4 ± 1.1%). Skimmianine pretreatment significantly improved these alterations, increasing TAS to 1.29 ± 0.20 mmol Trolox Eq/L and reducing TOS, OSI, TNF-α, Iba1, and GFAP levels to 9.20 ± 2.04, 7.07 ± 0.47, 34.9 ± 7.4, 24.2 ± 6.9, and 237.0 ± 7.9, respectively, compared with the untreated I/R group. Histopathological scores for Purkinje cell loss, edema, vascular congestion, and TNF-α expression were also significantly reduced by skimmianine. Quantitative TEM analysis showed that I/R reduced myelin thickness (0.29 ± 0.05 vs. 0.53 ± 0.07 µm), increased G-ratio values (0.75 ± 0.05 vs. 0.63 ± 0.04), and increased vacuolized fibers (24.70 ± 4.20% vs. 3.20 ± 1.10%), whereas skimmianine partially restored myelin thickness (0.42 ± 0.07 µm), reduced the G-ratio (0.68 ± 0.05), and decreased vacuolized fibers (11.20 ± 2.80%; p < 0.05 vs. I/R). Molecular docking demonstrated favorable binding between skimmianine and TNF-α, with a predicted binding energy of −6.953 kcal/mol. Conclusions: These findings indicate that skimmianine exerts neuroprotective effects against secondary cerebellar injury following cerebral I/R through coordinated modulation of oxidative stress, systemic neuroinflammatory responses, astroglial injury-associated pathways, and inflammation-related mechanisms. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Figure 1

28 pages, 4779 KB

Open AccessArticle

Multi-Bioinformatics Approach Reveals COX5B-Mediated Modulation of Oxidative Phosphorylation and ROS Levels by Water and Ethanol Extracts of Schisandrae Fructus in SW1783 Cells

by Musun Park, No Soo Kim, Jin-Mu Yi and Seongwon Cha

Antioxidants 2026, 15(6), 728; https://doi.org/10.3390/antiox15060728 - 9 Jun 2026

Viewed by 378

Abstract

Schisandrae Fructus is a traditional medicinal herb used to suppress hyperactivity and exhibits a wide range of therapeutic effects and few side effects; however, the molecular mechanism of action engaged by the multiple compounds found within Schisandrae Fructus remains insufficiently studied. Herein, we aimed to confirm the inhibition of oxidative phosphorylation by hot water and ethanol extracts of Schisandrae Fructus and determine the activity and pathways affected by each extract. To refine target prediction, centrality analysis was performed using drug–target interactions, protein–protein interactions, and integrated networks. Our analyses revealed that oxidative phosphorylation was inhibited in the water extract, and COX5B was predicted to be a common target. Centrality analysis revealed COX5B’s high score, suggesting its role as an efficient mediator of oxidative phosphorylation regulation. In vitro analysis confirmed that COX5B expression, oxidative phosphorylation activity and reactive oxygen species levels were suppressed by the water extract. The water and ethanol extracts of Schisandrae Fructus differentially affected oxidative phosphorylation activity. COX5B, a key target regulated by the water extract of Schisandrae Fructus, emerged as a potential biomarker. These findings suggest that COX5B-mediated oxidative phosphorylation modulation may serve as a key mechanism underlying the anticancer and antiaging effects of Schisandrae Fructus. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Graphical abstract

22 pages, 1527 KB

Open AccessArticle

Tomato Intake Improves Cognitive Performance and Modulates Functional Brain Networks in Healthy Adults: A Randomized Crossover Clinical Trial

by Ricardo López-Solís, Carolina Donat-Vargas, Patricia Ramírez-Carrasco, Rocío M. Gutiérrez-Romero, Maria Pérez, Magda Castellví, Beatriz Bosch, Camila Arancibia-Riveros, Alejandro Hinojosa-Moscoso, Carlos Laredo, Emma Muñoz-Moreno, Ana Maria Ruiz-Leon, Rosa Casas, Ramon Estruch, Anna Vallverdú-Queralt, Marina Corrado and Rosa M. Lamuela-Raventós

Antioxidants 2026, 15(5), 644; https://doi.org/10.3390/antiox15050644 - 19 May 2026

Cited by 1 | Viewed by 1806

Abstract

Tomatoes are the major dietary source of lycopene, a carotenoid that crosses the blood–brain barrier and exerts antioxidant and anti-inflammatory effects. However, the impact of tomato consumption on cognitive function in healthy adults remains unclear. This study assessed the effects of concentrated tomato paste on cognitive performance and explored potential mechanisms, including brain-derived neurotrophic factor (BDNF) and functional brain connectivity. A randomized, two-period crossover trial (ClinicalTrials.gov: NCT05891977) was conducted in 47 healthy adults aged 40–55 years assigned to two 3-month interventions separated by a 1-month washout: (a) daily consumption of concentrated tomato paste (0.5 g/kg body weight) and (b) a lycopene-restricted control diet. Cognitive performance was evaluated using validated neuropsychological tests (d2-R, Face-Name Associative Memory Exam, Modified Wisconsin Card Sorting Test), alongside plasma lycopene and BDNF, and resting-state functional magnetic resonance imaging (fMRI). Forty-two participants completed the study. Tomato intake improved selective attention (concentration performance: +7.2 points; processing speed: +8.3 points) and associative memory (face-name matching: +0.8 points). Plasma BDNF showed a borderline increase with tomato intake (mean difference 15.2 ng/mL). Resting-state fMRI revealed changes in brain networks, including reduced connectivity in frontoparietal and auditory networks, contrasting with reductions in the dorsal attention network during the control period. These findings provide evidence that tomato consumption may support cognitive function and modulate brain connectivity in healthy middle-aged adults. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Graphical abstract

23 pages, 4791 KB

Open AccessArticle

A Novel Gastrodin Derivative with Neuroprotection Promotes NGF-Mimic Activity by Targeting INSR and ACTN4 to Activate PI3K/Akt Signaling Pathway in PC12 Cells

by Jiayuan Zeng, Jianxia Mo, Makoto Muroi, Hiroyuki Osada, Lan Xiang and Jianhua Qi

Antioxidants 2025, 14(3), 344; https://doi.org/10.3390/antiox14030344 - 14 Mar 2025

Cited by 4 | Viewed by 3284

Abstract

Gastrodin (gas) has been shown to promote neuroprotection and reverse Alzheimer’s disease (AD) pathology. However, its high effective dose limits its potential in treating AD. In this study, a bioassay system using PC12 cells and the nerve growth factor (NGF)-mimic effect was employed to investigate the structure–activity relationship of gas derivatives. Among the synthesized compounds, GAD037 demonstrated the highest NGF-mimic activity, surpassing gas. Additionally, GAD037 exhibited significant neuroprotective effects, reducing reactive oxygen species (ROS) and malondialdehyde (MDA) levels, thereby improving the survival of PC12 cells under oxidative stress. It also protected cells from Aβ-induced toxicity. Target protein identification and mechanistic studies revealed that insulin receptor (INSR) and alpha-actinin-4 (ACTN4) are potential targets of GAD037, confirmed through specific inhibitors, small interfering RNA (siRNA) analysis, a cellular thermal shift assay (CETSA), and drug affinity responsive target stability (DARTS). Moreover, the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and rat sarcoma (Ras)/protooncogene serine–threonine protein kinase (Raf)/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathways were found to be involved in the NGF-mimic activity of GAD037. In conclusion, GAD037 exhibits superior NGF-mimic and neuroprotective activities compared to gas, suggesting its potential as a lead compound for anti-AD applications. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Figure 1

17 pages, 10721 KB

Open AccessArticle

Ethyl Acetate Fraction of Chestnut Honey Attenuates Scopolamine-Induced Cognitive Impairment in Mice and Glutamate-Induced Neurotoxicity in HT22 Cells

by Yun Hee Jeong, Wei Li, Hye Jin Yang, Se-Gun Kim, Hong Min Choi, Jang-Gi Choi and You-Chang Oh

Antioxidants 2024, 13(11), 1346; https://doi.org/10.3390/antiox13111346 - 2 Nov 2024

Cited by 4 | Viewed by 2779

Abstract

Chestnut honey has various benefits, such as antioxidative, anti-inflammatory, immunomodulatory, antibacterial, and antiviral effects. However, the effects of chestnut honey or the ethyl acetate fraction of chestnut honey (EACH) on neurodegenerative diseases and their related cognitive impairment and neurotoxicity have not yet been established. Therefore, in this study, we investigated the mitigating effect of the EACH on scopolamine (SCO)-injected cognitive decline in mice and glutamate-exposed neurotoxicity in HT22 cells. EACH administration significantly reversed SCO-induced cognitive decline in mice, as demonstrated through the Morris water maze and passive avoidance tests. The EACH treatment showed a significant alleviation effect by recovering more than 80% of the cell viability decrease induced by glutamate exposure in the HT22 neuronal cell model. Furthermore, the EACH significantly reduced reactive oxygen species accumulation, lactate dehydrogenase release, mitochondrial depolarization, and neuronal apoptosis. The EACH regulated the level of apoptosis-related proteins, induced the nuclear translocation of nuclear factor-E2-related factor 2 (Nrf-2) and the expression of related antioxidant proteins, and induced the phosphorylation of tropomyosin-related kinase receptor B (TrkB)/cAMP-calcium response element-binding protein (CREB) and the expression of brain-derived neurotrophic factor. These data indicate that the EACH can prevent neurons from oxidative damage and improve cognitive dysfunction by activating Nrf-2 and TrkB/CREB signaling pathways. Therefore, the EACH demonstrates potential therapeutic value in mitigating oxidative stress-induced neurotoxicity, cognitive decline, and related neurodegenerative diseases. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Figure 1

21 pages, 5941 KB

Open AccessArticle

Bioactivated Glucoraphanin Modulates Genes Involved in Necroptosis on Motor-Neuron-like Nsc-34: A Transcriptomic Study

by Aurelio Minuti, Alessandra Trainito, Agnese Gugliandolo, Ivan Anchesi, Luigi Chiricosta, Renato Iori, Emanuela Mazzon and Marco Calabrò

Antioxidants 2024, 13(9), 1111; https://doi.org/10.3390/antiox13091111 - 14 Sep 2024

Cited by 1 | Viewed by 2360

Abstract

Research on bioactive compounds has grown recently due to their health benefits and limited adverse effects, particularly in reducing the risk of chronic diseases, including neurodegenerative conditions. According to these observations, this study investigates the activity of sulforaphane (RS-GRA) on an in vitro model of differentiated NSC-34 cells. We performed a transcriptomic analysis at various time points (24 h, 48 h, and 72 h) and RS-GRA concentrations (1 µM, 5 µM, and 10 µM) to identify molecular pathways influenced by this compound and the effects of dosage and prolonged exposure. We found 39 differentially expressed genes consistently up- or downregulated across all conditions. Notably, Nfe2l2, Slc1a5, Slc7a11, Slc6a9, Slc6a5, Sod1, and Sod2 genes were consistently upregulated, while Ripk1, Glul, Ripk3, and Mlkl genes were downregulated. Pathway perturbation analysis showed that the overall dysregulation of these genes results in a significant increase in redox pathway activity (adjusted p-value 1.11 × 10⁻³) and a significant inhibition of the necroptosis pathway (adjusted p-value 4.64 × 10⁻³). These findings suggest RS-GRA’s potential as an adjuvant in neurodegenerative disease treatment, as both increased redox activity and necroptosis inhibition may be beneficial in this context. Furthermore, our data suggest two possible administration strategies, namely an acute approach with higher dosages and a chronic approach with lower dosages. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Figure 1

17 pages, 4323 KB

Open AccessArticle

Unveiling the Therapeutic Potential of Kelulut (Stingless Bee) Honey in Alzheimer’s Disease: Findings from a Rat Model Study

by Ammara Shaikh, Fairus Ahmad, Seong Lin Teoh, Jaya Kumar and Mohamad Fairuz Yahaya

Antioxidants 2024, 13(8), 926; https://doi.org/10.3390/antiox13080926 - 30 Jul 2024

Cited by 11 | Viewed by 7588

Abstract

Alzheimer’s disease (AD) poses a major worldwide health challenge because of its profound impact on cognitive abilities and overall well-being. Despite extensive research and numerous clinical trials, therapeutic options remain limited. Our study aimed to investigate the potential of Kelulut honey (KH) as a novel therapeutic agent for addressing the multifactorial pathology of AD. We tried to evaluate the disease-attenuating and neuroprotective potential of KH in the intrahippocampally induced AD rat model by utilizing histochemistry and enzyme-linked immunosorbent assay (ELISA) studies. A total of 26 male Sprague Dawley rats weighing ~280–380 g were randomly divided into three groups: Control, AD-induced (Aβ), and AD-induced and treated with KH (Aβ+KH). The latter two groups underwent stereotaxic surgery, where 6.25 µg of amyloid β_1–42 peptides were injected intrahippocampally. One-week post-surgery, KH was administered to the treatment group at a dose of 1 g/kg body weight for a period of four weeks, after which the rats went through behavior tests. After completion of behavior analysis, the rats were sacrificed, and the brains were processed for histochemistry and ELISA studies. The open field test analysis demonstrated that KH improved the locomotion of Aβ+KH compared to Aβ (p = 0.0013). In comparison, the Morris water maze did not show any nootropic effects on cognition with a paradoxical increase in time spent in the target quadrant by the Aβ group (p = 0.029). Histochemical staining showed markedly increased Congo-red-stained amyloid plaques, which were significantly reduced in dentate gyrus of Aβ+KH compared to Aβ (p < 0.05). Moreover, significantly higher apoptosis was seen in the Aβ group compared to Aβ+KH (p < 0.01) and control groups (p < 0.001). Furthermore, the ELISA studies deduced more phosphorylated tau in the diseased group compared to Aβ+KH (p = 0.038) and controls (p = 0.016). These findings suggest that KH consumption for twenty-eight days has the potential to attenuate the pathological burden of disease while exerting neuroprotective effects in rodent models of AD. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Figure 1

Review

Jump to: Research

65 pages, 1590 KB

Open AccessReview

Glucosinolate Metabolites and Brain Health: An Updated Review on Their Potential Benefits in Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders

by Claudia Muscarà, Agnese Gugliandolo, Emanuela Mazzon and Gabriella Calì

Antioxidants 2025, 14(7), 818; https://doi.org/10.3390/antiox14070818 - 2 Jul 2025

Cited by 7 | Viewed by 3949

Abstract

Neurodegenerative, neurodevelopmental, and psychiatric disorders, as well as epilepsy, affect millions of people. Due to their impact on patients’ quality of life, they represent a major health issue. Natural compounds are arising as new treatments for these diseases. Particularly, glucosinolates (GLS) are secondary metabolites found in Cruciferae family plants. Their basic structure consists of a glucose unit linked to a thiohydroximate-O-sulfonate group and an aliphatic, aralkyl, or indolyl side chain, depending on their precursor amino acid. Specifically, aliphatic GLS derive from methionine, aromatic ones from phenylalanine, and indolic ones from tryptophan. Myrosinase (thioglucoside glucohydrolase) is the crucial enzyme for GLS degradation, leading to the production of isothiocyanates (ITCs). ITCs attracted considerable scientific interest for their protective effects against various diseases, thanks to their antioxidant, anti-inflammatory, and neuroprotective properties. Here, we collected the latest evidence regarding ITC effects in neurodegenerative, neurodevelopmental, and psychiatric disorders, including preclinical and clinical studies published in the last decade. These studies evidenced ITCs’ neuroprotective effects, exerted mainly through antioxidant and anti-inflammatory mechanisms. Thus, ITCs’ integration, also through the diet, may represent a safe and efficacious strategy to improve health and limit the risk of neurological and psychiatric disorders. However, new large-scale trials are needed to determine their therapeutic potential, particularly for diseases with no clinical evidence. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Figure 1

37 pages, 7050 KB

Open AccessReview

Role of Plant Phytochemicals: Resveratrol, Curcumin, Luteolin and Quercetin in Demyelination, Neurodegeneration, and Epilepsy

by Mikołaj Grabarczyk, Weronika Justyńska, Joanna Czpakowska, Ewa Smolińska, Aleksandra Bielenin, Andrzej Glabinski and Piotr Szpakowski

Antioxidants 2024, 13(11), 1364; https://doi.org/10.3390/antiox13111364 - 7 Nov 2024

Cited by 53 | Viewed by 13326

Abstract

Polyphenols are an important group of biologically active compounds present in almost all food sources of plant origin and are primarily known for their anti-inflammatory and antioxidative capabilities. Numerous studies have indicated their broad spectrum of pharmacological properties and correlations between their increased supply in the human diet and lower prevalence of various disorders. The positive effects of polyphenols application are mostly discussed in terms of cardiovascular system well-being. However, in recent years, they have also increasingly mentioned as prophylactic and therapeutic factors in the context of neurological diseases, being able to suppress the progression of such disorders and soothe accompanying symptoms. Among over 8000 various compounds, that have been identified, the most widely examined comprise resveratrol, curcumin, luteolin and quercetin. This review focuses on in vitro assessments, animal models and clinical trials, reflecting the most actual state of knowledge, of mentioned polyphenols’ medicinal capabilities in epilepsy, demyelinating and neurodegenerative diseases of the central nervous system. Full article

(This article belongs to the Special Issue Role of Natural Antioxidants on Neuroprotection)

► Show Figures

Journal Menu

Journal Browser

Role of Natural Antioxidants on Neuroprotection

Share This Special Issue

Editors

Special Issue Information

Keywords

Benefits of Publishing in a Special Issue

Published Papers (9 papers)

Research

Review

Further Information

Guidelines

MDPI Initiatives

Follow MDPI