Mining Actinomycetes for New Antimicrobial Agents
A special issue of Antibiotics (ISSN 2079-6382).
Deadline for manuscript submissions: 30 November 2026 | Viewed by 141
Special Issue Editor
Interests: antibiotics; glycopeptide antibiotics; antibiotic resistance mechanism; fermentation; strain improvement; microbial biotechnology; genetic engineering; regulation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The rapid emergence of antimicrobial resistance has created an urgent need for new therapeutic agents with novel modes of action. The World Health Organization has warned that, if left unaddressed, antimicrobial resistance could become one of the leading causes of mortality worldwide by 2050, potentially resulting in millions of deaths annually and placing an unprecedented burden on global healthcare systems and economies. In this context, Actinomycetes remain one of the most prolific sources of clinically important antibiotics and structurally diverse natural products. This Special Issue, “Mining Actinomycetes for New Antimicrobial Agents,” aims to highlight recent advances in the discovery, characterization, and development of new antimicrobial compounds.
We invite original research articles, reviews, and short communications that explore innovative strategies such as genome mining, metagenomics, synthetic biology, and metabolomics, as well as research from extreme environments, to unlock silent biosynthetic gene clusters and expand the antimicrobial pipeline. Contributions addressing novel bioactive compounds, biosynthetic pathways, strain improvement, mechanisms of action, and applications against drug-resistant pathogens are particularly welcome. By integrating classical microbiology with modern omics and biotechnological approaches, this Special Issue seeks to provide a comprehensive perspective on how Actinomycetes can contribute to next-generation solutions for combating antimicrobial resistance.
Dr. Elisa Binda
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- actinomycetes
- antimicrobial agents
- antimicrobial discovery
- natural products
- secondary metabolites
- drug discovery
- genome mining
- biosynthetic gene clusters
- antimicrobial resistance
- OMICS approaches
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