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Antibiotics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Spread of Antibiotic Resistance in Natural Environments

edited by

Daniel Gyamfi Amoako

submission deadline 15 Dec 2025 | 6 articles | Viewed by 25166 | Submission Open

Keywords: antibiotic resistance dissemination; antibiotic pollution; environmental adaptation; mobile genetic elements; ecological impact; environmental microbiome; resistance gene transfer; resistance hotspot; genomic landscape; One Health approach; emerging contaminants; bioinformatics in environmental genomics

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Resistance and Environmental Health, 2nd Edition

edited by

Akebe Luther King Abia

submission deadline 15 Dec 2025 | 2 articles | Viewed by 4296 | Submission Open

Keywords: public health; environmental health; antibiotic resistance; environmental resistome; antibiotic-resistant bacteria; whole-genome sequencing; metagenomics; climate change and AMR; AMR models and One Health

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antibiotic Surveillance and Rational Use in Special Populations: Enhancing Stewardship for Vulnerable Groups

edited by

Phumzile P Skosana

and

Filippo Mariano

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3639 | Submission Open

Keywords: antibiotic stewardship; surveillance systems; special populations; rational use of antibiotics; infectious disease management

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Environmental Risk and Antibiotic Resistance in Hospital-Acquired Infections

edited by

Catherine Neuwirth

submission deadline 20 Dec 2025 | Viewed by 177 | Submission Open

Keywords: nosocomial outbreak; environmental reservoir; investigation; corrective actions; short- and long-term outcomes

Antibiotics and Antimicrobial Resistance in Aquaculture: Alternative and Complementary Treatment Methods

edited by

Jaime Romero

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2983 | Submission Open

Keywords: antibiotics; antimicrobial resistance; alternatives; aquaculture; probiotics; phage therapy

Phage Applications from Diagnostics to Treatment of Bacterial Infections in a One Health World

edited by

Mariagrazia Di Luca

and

Goran Vukotic

submission deadline 31 Dec 2025 | 8 articles | Viewed by 48336 | Submission Open

Keywords: phage therapy; antibiotic resistance; bacteriophages; regulatory framework; veterinary medicine; agriculture treatment; aquaculture

(This special issue belongs to the Section Bacteriophages)

Antibiotic Use and Antimicrobial Stewardship for Children in the Emergency Department

edited by

Michael Barrett

and

Spyridon Karageorgos

submission deadline 31 Dec 2025 | 8 articles | Viewed by 44439 | Submission Open

Keywords: pediatric ED; ambulatory; antimicrobial stewardship; antibiotic use; antimicrobial resistance; point-of-care testing

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Epidemiology and Mechanism of Bacterial Resistance to Antibiotics

edited by

Gabriela Loredana Popa

and

Mircea Ioan Popa

submission deadline 31 Dec 2025 | 10 articles | Viewed by 31172 | Submission Open

Keywords: multi-drug resistant (MDR); classic and molecular epidemiology; plasmids; resistance gene

Bacterial Detection, Identification, and Antimicrobial Susceptibility Testing

edited by

Gabriele Bianco

submission deadline 31 Dec 2025 | 8 articles | Viewed by 30678 | Submission Open

Keywords: identification methods; rapid diagnostics; MALDI-TOF MS; molecular testing; rapid antimicrobial susceptibility testing; antimicrobial susceptibility; synergy testing; β -lactam/β -lactamase inhibitor; fosfomycin; colistin

Antibiotic Resistance: A One-Health Approach, 2nd Edition

edited by

Piera Anna Martino

submission deadline 31 Dec 2025 | 11 articles | Viewed by 30242 | Submission Open

Keywords: antibiotic-resistance; One Health; virulence factors; genomics; novel natural molecules; antimicrobial stewardship

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Computational Approaches in Discovery and Design of Antimicrobial Peptides—2nd Edition

edited by

Guillermin Agüero-Chapin

Yovani Marrero-Ponce

and

Agostinho Antunes

submission deadline 31 Dec 2025 | 7 articles | Viewed by 26782 | Submission Open

Keywords: rational search and design of AMPs; alignment-based and alignment-free approaches; machine-learning; artificial intelligence; biodiscovery with associated computational analyses/tools; non-conventional in silico approaches

(This special issue belongs to the Section Antimicrobial Peptides)

Bacteriophage Therapy a Renaissance Weapon Recent Developments and Application, 2nd Edition

edited by

Aneta Skaradzińska

and

Paulina Śliwka

submission deadline 31 Dec 2025 | 9 articles | Viewed by 22033 | Submission Open

Keywords: bacteriophages; phage therapy; application of phages; antibiotic-resistance; antibacterial therapies

(This special issue belongs to the Section Bacteriophages)

Preventing Antimicrobial Resistance in Hospitals: Infection Control and Antibiotic Use

edited by Dorota Pastuszak-Lewandoska,

Filip Bielec

and Małgorzata Brauncajs

submission deadline 31 Dec 2025 | 8 articles | Viewed by 21536 | Submission Open

Keywords: clinical antibiotic use; hospital infection control; healthcare-associated infections; resistance mitigation strategies; alternative therapies; antibiotic stewardship; molecular mechanisms of AMR; new therapeutic combinations of antibiotics; antimicrobial synergy

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens

edited by

Andrés H. Uc-Cachón

and

Gloria María Molina-Salinas

submission deadline 31 Dec 2025 | 7 articles | Viewed by 17071 | Submission Open

Keywords: anti-infective agents; antimicrobial activity; human pathogens; medicinal plants; natural products; phytodrugs

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antibiotic Treatment on Surgical Infections

edited by

Fausto Catena

submission deadline 31 Dec 2025 | 4 articles | Viewed by 15744 | Submission Open

Keywords: surgical site; infection; emergency surgery; prevention

Antimicrobial Resistance in the Community Setting: The Other Side of the Coin

edited by

Luigi Principe

submission deadline 31 Dec 2025 | 4 articles | Viewed by 13924 | Submission Open

Keywords: emerging resistance; multidrug resistance; emerging virulence; community setting; Staphylococcus aureus; Enterococcus spp.; Streptococcus spp.; Haemophilus spp.; Moraxella spp.; Mycobacterium spp.; Neisseria spp.; Salmonella spp.; Shigella spp.; Campylobacter spp.; anaerobes; fungi

Advancing the Discovery and Development of New Antibiotics through Drug Repurposing

edited by Songping Huang

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11909 | Submission Open

(This special issue belongs to the Section Novel Antimicrobial Agents)

Biofilms and Urinary Tract Infections

edited by

Dino Sgarabotto

and

Anabela Borges

submission deadline 31 Dec 2025 | 1 articles | Viewed by 11733 | Submission Open

(This special issue belongs to the Section Antibiofilm Strategies)

A One Health Approach to Antimicrobial Resistance, 2nd Edition

edited by

Beatriz Robredo

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10883 | Submission Open

Keywords: One Health; antibiotic; antimicrobial resistance; animal; food; environment

Therapy of Infectious Diseases Among Children and Adults: The Role of Antibiotics in Daily Practice

edited by

Magdalena Baymakova

and

Valeri R. Velev

submission deadline 31 Dec 2025 | 6 articles | Viewed by 8681 | Submission Open

Keywords: аntibiotic use among children; аntibiotic use among adults; аntibiotic use among outpatients; аntibiotic use among inpatients; antibiotic resistance; improper antibiotic use; antibiotic quality control

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Antimicrobial Resistance in Veterinary Science, 2nd Edition

edited by

Nahla O. Eltai

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8322 | Submission Open

Keywords: AMR; veterinary animals; farm animals; food animals; wild animals; resistance

(This special issue belongs to the Section Antibiotics in Animal Health)

Molecular Characterization and Antimicrobial Resistance of Pathogens Isolated from Animals

edited by

Isabel Carvalho

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7376 | Submission Open

Keywords: antibiotic resistance; molecular biology; microbiology; genomics; multi-drug resistance; One Health; animals

(This special issue belongs to the Section Antibiotics in Animal Health)

Therapeutic Drug Monitoring of Antimicrobials in Critically Ill Patients

edited by Young Ran Lee

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7375 | Submission Open

Keywords: therapeutic drug monitoring (TDM); antibiotics; antimicrobials; pharmacokinetic; pharmacodynamic; critically ill

(This special issue belongs to the Section Pharmacokinetics and Pharmacodynamics of Drugs)

Bioactive Natural Products in Antimicrobial Resistance Management

edited by

Ljubiša Šarić

Zorica Tomičić

and

Ružica Tomičić

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6146 | Submission Open

Keywords: antimicrobials; antimicrobial resistance; bioactive natural products; novel antimicrobial agents; phytochemicals

(This special issue belongs to the Section Plant-Derived Antibiotics)

Antibiotic Stewardship in Ambulatory Care Settings

edited by Mary Elizabeth Sexton and Sharon V. Tsay

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5987 | Submission Open

Keywords: ambulatory antimicrobial stewardship; antimicrobial resistance

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Antibacterial Utilisation from Different Perspectives: An Effective Tool to Develop and Evaluate Antimicrobial Stewardship Interventions

edited by

Gyöngyvér Soós

and

Ria Benkő

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5458 | Submission Open

Keywords: quality of antibiotic use; scale of antibiotic use; pattern of antibiotic use; prevalence of antibiotic use; specific patient populations; safety of use; antibacterial; antivirals; antifungals; anti-TBC

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

The Issue of Multidrug-Resistant Pathogens in Nosocomial Infections, 2nd Edition

edited by

Alberto Enrico Maraolo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5448 | Submission Open

Keywords: antimicrobial resistance; MDR; XDR; DTR; nosocomial infections

Research Advances in Antimicrobial Stewardship, Residues and Resistance in Veterinary and Environmental Science

edited by Justine S. Gibson and

Ricardo J. Soares Magalhães

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5384 | Submission Open

Keywords: antimicrobial resistance (AMR); antimicrobial stewardship (AMS); antimicrobial residues (ARs); diagnostic tools and therapeutics; epidemiology; sustainable AMR mitigation; one health; veterinary sciences

(This special issue belongs to the Section Antibiotics in Animal Health)

Gram-Negative Multidrug-Resistant Pathogens and Their Treatment, 2nd Edition

edited by

Ramón Pérez-Tanoira

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5221 | Submission Open

Keywords: carbapenemase-producing enterobacteriaceae; multidrug-resistant and extensively drug-resistant Pseudomonas aeruginosa; gram-negative bacteria and antibiotic resistance mechanisms; multidrug resistant; extended-spectrum beta-lactamase (ESBL) producers; antibacterial potential of novel compounds; biofilm inhibition strategies; quorum sensing disruption as a therapeutic approach

Global Strategies for Antimicrobial Surveillance: Country, Regional and Global Perspectives

edited by

Gustavo Horacio Marin

and Gabriel Levy-Hara

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5053 | Submission Open

Keywords: antimicrobial; stewardship; resistance; consumption; use

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Hospital-Associated Infectious Diseases and Antibiotic Therapy

edited by Carola Mauri and

Alessandra Consonni

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4742 | Submission Open

Keywords: hospital-associated infectious diseases; epidemiology; treatment; antibiotic stewardship; antimicrobial resistance; multi-drug resistance

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Clostridioides difficile Infection, 3rd Edition

edited by

Guido Granata

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4701 | Submission Open

Keywords: Clostridioides difficile; Clostridioides difficile infection recurrence; antimicrobial use; host and microbiota interaction; CDI

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

Veterinary Antibiotics in Food-Producing Animals: Residue Detection, Risk Assessment and Regulatory Advances

edited by

Liliana J.G. Silva

and

Marta Leite

submission deadline 31 Dec 2025 | 5 articles | Viewed by 4044 | Submission Open

Keywords: veterinary drugs; analytical chemistry; food safety; risk assessment; regulatory frameworks

(This special issue belongs to the Section Antibiotics in Animal Health)

Prevention and Antimicrobial Surveillance of Hospital-Associated Infections

edited by Theodouli Stergiopoulou

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3973 | Submission Open

Keywords: infection monitoring; surveillance program; antimicrobial surveillance; healthcare-associated infections

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Tackling Multidrug-Resistant Bacteria with New Antimicrobial Strategies

edited by

Vivek Keshri

and

Marc Maresca

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3905 | Submission Open

Keywords: multidrug-resistant (MDR); antimicrobial resistance (AMR); novel antibiotics; drug discovery; AMR surveillance; epidemiology

(This special issue belongs to the Section Novel Antimicrobial Agents)

Origins and Evolution of Antibiotic Resistance in the Environment

edited by

Damian Rolbiecki

and

Małgorzata Czatzkowska

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3798 | Submission Open

Keywords: surface water; soil; wastewater; antibiotic resistance genes; antibiotic resistant bacteria; One Health; WHO pathogens; anthropogenic pressure

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Recent Advances in Efflux Pump Inhibitors and Their Role in Combatting Multidrug Resistance

edited by

László Orosz

and

Spengler Gabriella

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3792 | Submission Open

Keywords: multidrug resistance; multidrug efflux pump; efflux pump inhibitor (EPI); accumulation assay; efflux assay; fluorochromes; ethidium bromide; quorum sensing; biofilm

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Biofilm-Associated Oral Diseases: Advances in Diagnosis and Challenges in Treatment

edited by

Naiera Zayed

and Cher Farrugia

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3578 | Submission Open

Keywords: oral diseases; oral biofilms; host– biofilm interactions; novel antimicrobial strategies; molecular dynamics

(This special issue belongs to the Section Antibiofilm Strategies)

Multidrug-Resistant Pathogens: Genomic Analysis, Resistance Mechanisms, and Clinical Challenges

edited by

Dusan Kekic

and Nemanja Stanisavljevic

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3567 | Submission Open

Keywords: multidrug-resistant pathogens; genomic analysis; antimicrobial resistance; resistance mechanisms; antimicrobial therapy challenges; new antimicrobial drugs and therapies; clinical antimicrobial guidelines

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Antimicrobial Resistance from a One Health Perspective

edited by

Flávia L P. C. Pellegrino

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3155 | Submission Open

Keywords: antimicrobial resistance mechanisms; bacterial virulence; clonal diversity; molecular epidemiology; antibiotic use; infectious diseases; One Health

Antibiotic Bans and Antimicrobial Resistance: Progress, Challenges, and Future Strategies

edited by

Abdelaziz Ed-Dra

and

Min Yue

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2850 | Submission Open

Keywords: impact of antibiotic bans; antibiotic use; antimicrobial resistance; antibiotic restrictions

(This special issue belongs to the Section Antibiotics Use and Antimicrobial Stewardship)

Impact of Antibiotic Residues in Wastewater

edited by Jose Sanchez-Salas

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2689 | Submission Open

Keywords: antibiotic residues; wastewater treatment; environmental antibiotics; pharmaceutical contaminants; antimicrobial resistance

Antimicrobial Extracts and Compounds Derived from Plants

edited by

Giovanna Simonetti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2332 | Submission Open

Keywords: antibacterial; antifungal; plant extract; plant compounds; antibiotic-resistant strains; virulence factors; synergistic interactions

(This special issue belongs to the Section Plant-Derived Antibiotics)

Genomic Insights into Dissemination of Multi-Drug Resistance Pathogens

edited by

Vanessa Silva

and

Gilberto Igrejas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2103 | Submission Open

Keywords: antimicrobial resistance; genomic surveillance; MDR; gene transfer; One Health

Repositioning Drugs as a Strategy to Combat Infections

edited by

Hélcio Silva Dos Santos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2049 | Submission Open

Keywords: repositioning drugs; efflux pump inhibitors; resistant microorganisms; microbial biofilm; antibacterial resistance; antifungal potential

(This special issue belongs to the Section The Global Need for Effective Antibiotics)

Foodborne Pathogens: Detection, Resistance Mechanisms, and Control Strategies

edited by

Joana Campos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2041 | Submission Open

Keywords: foodborne pathogens; antimicrobial resistance; rapid detection methods; control strategies; food safety interventions; One Health

Antibacterial Treatment in Periodontal and Endodontic Therapy, 3rd Edition

edited by

Andreas Braun

and

Felix Krause

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1865 | Submission Open

Keywords: periodontology; endodontology; cariology; photodynamics; laser dentistry

New Insights Toward the Development of Novel Inhibitors of S. aureus and P. aeruginosa Factors

edited by Que Chi Truong-Bolduc, Leon G. Leanse,

Hidemasa Nakaminami

and

Chun-Hsing Liao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1860 | Submission Open

Keywords: MSSA; MRSA; P. aeruginosa; coinfection; antibiotic resistance; therapeutic strategy; anti-virulence; quorum-sensing; virulence factors; biofilms

(This special issue belongs to the Section Novel Antimicrobial Agents)

ESKAPEE: Mechanisms, Spread, and Evolution of Antimicrobial Resistance

edited by Ning Dong and Yarong Wu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1507 | Submission Open

Keywords: ESKAPE pathogens; antimicrobial resistance; genomic epidemiology

(This special issue belongs to the Section Mechanism and Evolution of Antibiotic Resistance)

Innovative Treatments for Hospital-Acquired Multidrug-Resistant Bacterial Infections

edited by

Lucas de Paula Ramos

Cristina Pacheco-Soares

, Hugo Vigerelli and Florence Carrouel

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1197 | Submission Open

Keywords: antimicrobial agents; gram-negative aerobic rods and cocci; vancomycin resistance; cross-infection; infection control

(This special issue belongs to the Section Antibiotic Therapy in Infectious Diseases)

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