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Antibiotics
Special Issues
Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens
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Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1979

Special Issue Editors

Dr. Andrés H. Uc-Cachón

E-Mail Website
Guest Editor
Unidad de Investigación Médica Yucatán, Instituto Mexicano del Seguro Social, Mérida, Yucatán, Mexico
Interests: medicinal plants as sources of antibacterial, antiprotozoal and antidiabetic agents; antimicrobial resistance of group ESKAPE-E; clinical and epidemiological study of bacterial diseases
Dr. Gloria María Molina-Salinas

E-Mail Website
Guest Editor
Unidad de Investigación Médica Yucatán, Instituto Mexicano del Seguro Social, Mérida, Yucatán, Mexico
Interests: clinical and molecular epidemiology of emerging, re-emerging, and healthcare-associated infections; development of new agents against multidrug-resistant mycobacterium tuberculosis and ESKAPE-E bacteria; ethnopharmacological study of Mayan medicinal plants for anti-infective properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Pathogens, including bacteria, fungi, protozoa, helminths, and viruses, are responsible for millions of human fatalities. Coronavirus disease (COVID-19) and tuberculosis remain among the top 10 causes of global mortality. Furthermore, it is estimated that between now and 2050, more than 39 million individuals will die of antibiotic-resistant infections. Despite the availability of various drugs for infectious diseases, there is an urgent need for the development of novel therapies for emerging diseases, as well as for infections for which antibiotics are no longer effective due to antimicrobial resistance. Historically, plants have served as valuable sources of anti-infective agents, and numerous drugs used in contemporary medicine originate from botanical sources. The estimated number of plant species on Earth ranges from 250,000 to 500,000, many of which are utilized for medicinal purposes and are part of the healthcare systems in developing countries. In recent years, research has focused on the identification of plant extracts with activity against pathogens, with the objective of developing new phytodrugs. This Special Issue of Antibiotics presents the most recent research on plant extracts and their antimicrobial activities against emerging and drug-resistant pathogens.

Dr. Andrés H. Uc-Cachón
Dr. Gloria María Molina-Salinas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anti-infective agents
  • antimicrobial activity
  • human pathogens
  • medicinal plants
  • natural products
  • phytodrugs

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Published Papers (2 papers)

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Research

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26 pages, 13413 KiB  
Article
Use of Haloxylon scoparium Against Multidrug-Resistant Bacteria from Urinary Tract Infections
by Fouad Bahri, Abdelhadi Boussena, Antoni Szumny, Youcef Bahri, El-Mokhtar Bahri, Adam Figiel and Piotr Juszczyk
Antibiotics 2025, 14(5), 471; https://doi.org/10.3390/antibiotics14050471 - 6 May 2025
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Abstract
Background: The emergence of multidrug-resistant bacteria in the urinary tract and the decrease in the efficacy of antibiotics prompted us to evaluate the antibacterial activity of the methanolic extract of the aerial parts of Haloxylon scoparium against six isolated (MDR) bacteria. Methods: Phenolic [...] Read more.
Background: The emergence of multidrug-resistant bacteria in the urinary tract and the decrease in the efficacy of antibiotics prompted us to evaluate the antibacterial activity of the methanolic extract of the aerial parts of Haloxylon scoparium against six isolated (MDR) bacteria. Methods: Phenolic compound profiling of the extract of interest was performed by HPLC-DAD. Acute oral toxicity was tested in vivo. The antibiotic susceptibility of the isolates was assessed against 23 antibiotics using the disk diffusion method. The identification of the isolates was performed by 16S rRNA gene sequencing. The antibacterial activity of the extract was assessed using agar well diffusion, minimum inhibitory concentrations (MICs), and minimum bactericidal concentrations (MBCs) methods. Results: Phenolic compound profiling of the extract revealed that epicatechin (85%) was the major compound. The extract also showed no symptoms of toxicity, adverse effects, or mortality in mice at the recommended dose. Overall, the extract at 200 µg/mL was effective against all isolates. The zones of inhibition ranged from 9.25 to 19.5 mm. Gram-positive S. aureus bacteria recorded the highest inhibitory effect with 19.5 mm against the five Gram-negative bacteria (9.25–17.25 mm). The MIC of the extracts against clinical isolates ranged from 50 to 100 µg/mL. The extract was bactericidal against S. aureus, E. coli, E. ludwigii, and K. pneumoniae with an MBC of 100, 100, 200, and 200 µg/mL, respectively. Conclusions: The results conclude that the extract could be an effective source of antimicrobial agents for the treatment of urinary tract infections caused by MDR bacteria. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens)
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Review

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23 pages, 6045 KiB  
Review
Comprehensive Overview of Antibacterial Drugs and Natural Antibacterial Compounds Found in Food Plants
by Sabine Berteina-Raboin
Antibiotics 2025, 14(2), 185; https://doi.org/10.3390/antibiotics14020185 - 11 Feb 2025
Viewed by 1216
Abstract
The aim of this review is to list the various natural sources of antimicrobials that are readily available. Indeed, many plant sources are known to have antibiotic properties, although it is not always clear which molecule is responsible for this activity. Many food [...] Read more.
The aim of this review is to list the various natural sources of antimicrobials that are readily available. Indeed, many plant sources are known to have antibiotic properties, although it is not always clear which molecule is responsible for this activity. Many food supplements also have this therapeutic indication. We propose here to take stock of the scientific knowledge attesting or not to these indications for some food sources. An overview of the various antibiotic drugs commercially available will be provided. A structural indication of the natural molecules present in various plants and reported to contribute to their antibiotic power will be given. The plants mentioned in this review, which does not claim to be exhaustive, are referenced for fighting Gram-positive and/or Gram-negative bacteria. It is difficult to attribute activity to just one of these natural molecules, as it is likely to result from synergy within the plant. Similarly, chitosan is mentioned for its fungistatic and bacteriostatic properties. In this case, this polymeric compound derived from the chitin of marine organisms is referenced for its antibiofilm activity. It seems that, in the face of growing antibiotic resistance, it makes sense to keep high-performance synthetic antibiotics on hand to treat the difficult pathologies that require them. On the other hand, for minor infections, the use of better-tolerated natural sources is certainly sufficient. To achieve this, we need to take stock of common plant sources, available as food products or dietary supplements, which are known to be active in this field. Full article
(This article belongs to the Special Issue Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens)
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