Antimicrobial Activity of Plants Against Emerging or Drug-Resistant Human Pathogens

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Plant-Derived Antibiotics".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1498

Special Issue Editors


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Guest Editor
Unidad de Investigación Médica Yucatán, Instituto Mexicano del Seguro Social, Mérida, Yucatán, Mexico
Interests: medicinal plants as sources of antibacterial, antiprotozoal and antidiabetic agents; antimicrobial resistance of group ESKAPE-E; clinical and epidemiological study of bacterial diseases

E-Mail Website
Guest Editor
Unidad de Investigación Médica Yucatán, Instituto Mexicano del Seguro Social, Mérida, Yucatán, Mexico
Interests: clinical and molecular epidemiology of emerging, re-emerging, and healthcare-associated infections; development of new agents against multidrug-resistant mycobacterium tuberculosis and ESKAPE-E bacteria; ethnopharmacological study of Mayan medicinal plants for anti-infective properties
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Special Issue Information

Dear Colleagues,

Pathogens, including bacteria, fungi, protozoa, helminths, and viruses, are responsible for millions of human fatalities. Coronavirus disease (COVID-19) and tuberculosis remain among the top 10 causes of global mortality. Furthermore, it is estimated that between now and 2050, more than 39 million individuals will die of antibiotic-resistant infections. Despite the availability of various drugs for infectious diseases, there is an urgent need for the development of novel therapies for emerging diseases, as well as for infections for which antibiotics are no longer effective due to antimicrobial resistance. Historically, plants have served as valuable sources of anti-infective agents, and numerous drugs used in contemporary medicine originate from botanical sources. The estimated number of plant species on Earth ranges from 250,000 to 500,000, many of which are utilized for medicinal purposes and are part of the healthcare systems in developing countries. In recent years, research has focused on the identification of plant extracts with activity against pathogens, with the objective of developing new phytodrugs. This Special Issue of Antibiotics presents the most recent research on plant extracts and their antimicrobial activities against emerging and drug-resistant pathogens.

Dr. Andrés H. Uc-Cachón
Dr. Gloria María Molina-Salinas
Guest Editors

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Keywords

  • anti-infective agents
  • antimicrobial activity
  • human pathogens
  • medicinal plants
  • natural products
  • phytodrugs

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Published Papers (1 paper)

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Review

23 pages, 6045 KiB  
Review
Comprehensive Overview of Antibacterial Drugs and Natural Antibacterial Compounds Found in Food Plants
by Sabine Berteina-Raboin
Antibiotics 2025, 14(2), 185; https://doi.org/10.3390/antibiotics14020185 - 11 Feb 2025
Viewed by 1025
Abstract
The aim of this review is to list the various natural sources of antimicrobials that are readily available. Indeed, many plant sources are known to have antibiotic properties, although it is not always clear which molecule is responsible for this activity. Many food [...] Read more.
The aim of this review is to list the various natural sources of antimicrobials that are readily available. Indeed, many plant sources are known to have antibiotic properties, although it is not always clear which molecule is responsible for this activity. Many food supplements also have this therapeutic indication. We propose here to take stock of the scientific knowledge attesting or not to these indications for some food sources. An overview of the various antibiotic drugs commercially available will be provided. A structural indication of the natural molecules present in various plants and reported to contribute to their antibiotic power will be given. The plants mentioned in this review, which does not claim to be exhaustive, are referenced for fighting Gram-positive and/or Gram-negative bacteria. It is difficult to attribute activity to just one of these natural molecules, as it is likely to result from synergy within the plant. Similarly, chitosan is mentioned for its fungistatic and bacteriostatic properties. In this case, this polymeric compound derived from the chitin of marine organisms is referenced for its antibiofilm activity. It seems that, in the face of growing antibiotic resistance, it makes sense to keep high-performance synthetic antibiotics on hand to treat the difficult pathologies that require them. On the other hand, for minor infections, the use of better-tolerated natural sources is certainly sufficient. To achieve this, we need to take stock of common plant sources, available as food products or dietary supplements, which are known to be active in this field. Full article
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