Antimicrobial Resistance from a One Health Perspective

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: 31 December 2025 | Viewed by 893

Special Issue Editor


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Guest Editor
Integrated Research Laboratories on Antimicrobial Resistant Bacteria and Galenic Development (LIPE), Pharmacy Department, Faculty of Biological Sciences and Health (FCBS), Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil
Interests: antimicrobial resistant bacteria; bacterial virulence; urinary tract infection; antibiotic use; vaccine; One Health

Special Issue Information

Dear Colleagues,

Bacterial resistance to antimicrobial agents has been widely discussed for decades around the world. Although it is a natural phenomenon and an ancient concept, antimicrobial resistance is considered a current global problem that remains challenging for health professionals in developed or developing countries, such as Brazil.

Excessive prescription and indiscriminate consumption of antibiotics accentuate the problem, contributing to the selection of bacterial pathogens carrying antibiotic resistance genes and expressing resistance to multiple classes of antimicrobial drugs in clinical use.

Resistant bacteria are common as a cause of infections acquired both in the hospital and in the community environment. From a One Health perspective, antimicrobial resistance has a strong negative impact on the health of people and the planet.

In this sense, we invite you to publish in the Special Issue Antimicrobial Resistance from a One Health Perspective”, raising high-level discussions based on robust scientific results. Research articles and reviews addressing the following will be accepted:

  1. Antimicrobial resistance mechanisms and new therapeutic approaches;
  2. New substances and molecules with antimicrobial action;
  3. Innovation in the detection of the antimicrobial resistance;
  4. Virulence strategies of clinically relevant bacteria;
  5. Clonal diversity and molecular epidemiology of bacterial pathogens;
  6. Urinary tract infection by antimicrobial-resistant bacteria.

Dr. Flávia L P. C. Pellegrino
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimicrobial resistance mechanisms
  • bacterial virulence
  • clonal diversity
  • molecular epidemiology
  • antibiotic use
  • infectious diseases
  • One Health

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Published Papers (1 paper)

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Research

14 pages, 1515 KB  
Article
Assessment of Antimicrobial Resistance and Virulence of Biofilm-Forming Uropathogenic Escherichia coli from Rio de Janeiro
by Maria Clara F. Oliveira, Anna Luiza B. Canellas, Lidiane C. Berbert, Alexander M. Cardoso, Vitoria A. Silva, Samantha S. T. Garutti, Débora Hosana F. Rangel, Rubens Clayton S. Dias, Jamila Alessandra Perini, Claudia R. V. M. Souza, Thiago P. G. Chagas, Marinella S. Laport and Flávia Lúcia P. C. Pellegrino
Antibiotics 2025, 14(9), 869; https://doi.org/10.3390/antibiotics14090869 - 29 Aug 2025
Viewed by 648
Abstract
Background/Objectives: Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections in both community and hospital settings worldwide. Antimicrobial-resistant UPEC strains pose a significant challenge for effective antibiotic therapy. In this study, 50 bacterial isolates recovered from urine samples of patients [...] Read more.
Background/Objectives: Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections in both community and hospital settings worldwide. Antimicrobial-resistant UPEC strains pose a significant challenge for effective antibiotic therapy. In this study, 50 bacterial isolates recovered from urine samples of patients attended in different sectors of a public hospital in Rio de Janeiro over five months were analyzed to assess antimicrobial resistance and virulence profiles through broad gene screening. Methods: Biofilm production was assessed using a semi-quantitative adherence assay. PCR was employed to investigate 27 resistance genes, 6 virulence genes, sequence types (STs), and phylogroups. Susceptibility to 25 antimicrobial agents was determined by disk diffusion testing. Furthermore, the pathogenic potential was evaluated in vivo using the Tenebrio molitor larvae infection model. Results: Most UPEC isolates were moderate or strong biofilm producers (41/50; 82%). The sul1 and sul2 resistance genes were the most frequently detected (58%). Two virulence gene patterns were identified: fyuA, iutA, fimH, cnf1 and fyuA, iutA, fimH (13 isolates; 26%). ST131 and ST73 were the most common sequence types (16% each), and phylogroup B2 was the most prevalent (50%). Thirty isolates (60%) were multidrug-resistant, most of which belonged to phylogroup B2. UPEC exhibited dose-dependent lethality, causing 100% mortality at 2.6 × 108 CFU/mL within 24 h. Conclusions: These findings reinforce the urgent need for surveillance strategies and effective antimicrobial stewardship in clinical practice. Full article
(This article belongs to the Special Issue Antimicrobial Resistance from a One Health Perspective)
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