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Antibiotics
Special Issues
Advances in Antimicrobial Therapies for Oral Infections: From Biofilm Disruption...
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Advances in Antimicrobial Therapies for Oral Infections: From Biofilm Disruption to Clinical Applications

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiofilm Strategies".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 503

Special Issue Editors

Prof. Dr. Cláudia Helena Silva-Lovato

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Guest Editor
Department of Dental Materials and Prostheses, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, Brazil
Interests: biofilm in dental prosthesis; dental prosthesis sanitizers; maxillofacial prosthesis; acrylic resin; silicone
Special Issues, Collections and Topics in MDPI journals
Dr. Adriana Barbosa Ribeiro

E-Mail Website
Guest Editor
Department of Dental Materials and Prostheses, School of Dentistry of Ribeirão Preto, University of São Paulo, São Paulo 14040-904, Brazil
Interests: oral health maintenance; conventional and implant-retained dental prostheses; clinical dentistry with local and systemic implications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral infections, such as dental caries, periodontitis, oral candidiasis and denture stomatitis, are frequently associated with the formation of microbial biofilms that are resistant to conventional therapies. Advances in understanding the structure and behavior of biofilms have driven the development of new, more effective antimicrobial strategies. Studies have evaluated the control of oral infections through natural molecules, with the development of antibiofilm properties, essential oils, antimicrobial peptides, and emerging technologies such as nanoparticles, antimicrobial photodynamics and bacteriophages. In addition, the combination of physical, chemical and biological approaches has demonstrated synergistic potential, promoting greater efficacy and a lower risk of microbial resistance. Therefore, the application of these advances to clinical practice, with a focus on the prevention and treatment of oral infections, is extremely important. The incorporation of these innovative therapies into the dental routine represents a promising step in overcoming the challenges imposed by biofilms, contributing to the improvement of oral health and quality of life.

Prof. Dr. Cláudia Helena Silva-Lovato
Dr. Adriana Barbosa Ribeiro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral infections
  • microbial biofilm
  • antimicrobial therapies

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Published Papers (1 paper)

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Research

14 pages, 35554 KiB  
Article
Influence of Polishing and Glazing on Surface Characteristics and Biofilm Formation on Zirconia: An In Vitro Study
by Gabriela de Arruda Ribeiro, Viviane de Cássia Oliveira, Adriana Cláudia Lápria Faria, Ana Paula Macedo, Carla Roberta de Oliveira Maciel, Cláudia Helena Lovato da Silva, Ricardo Faria Ribeiro and Renata Cristina Silveira Rodrigues
Antibiotics 2025, 14(8), 739; https://doi.org/10.3390/antibiotics14080739 - 23 Jul 2025
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Abstract
Background: Monolithic zirconia has attracted considerable interest in dentistry due to its favorable physical and mechanical properties, making it a promising alternative for crown fabrication. Nonetheless, a standardized finishing protocol for this material has yet to be established. Objective: This study [...] Read more.
Background: Monolithic zirconia has attracted considerable interest in dentistry due to its favorable physical and mechanical properties, making it a promising alternative for crown fabrication. Nonetheless, a standardized finishing protocol for this material has yet to be established. Objective: This study aimed to evaluate the surface characteristics and in vitro biofilm formation of zirconia finished by either polishing or glazing. Methods: A total of 72 zirconia specimens were fabricated and divided into control, glazing, and polishing groups. Surface analysis included roughness, wettability, and surface free energy. Microbiological analysis included CFU (colony-forming units per mL) counts, microbial adhesion at 2, 4, 6, and 8 h, biofilm biovolume, and qualitative biofilm assessment via scanning electron microscopy (sEm). Results: The glazing group showed significantly greater roughness than the polishing (p = 0.006) and control (p = 0.016) groups, along with a lower contact angle (polishing—p = 0.002; control—p < 0.001) and higher surface energy (polishing—p = 0.005; control—p < 0.001). No significant differences were observed in CFU counts for the tested microorganisms (C. albicans, p = 0.158; L. casei, p = 0.610; S. mutans, p = 0.904). Regarding microbial adhesion, the polishing group showed a smaller biofilm-covered area compared to the control group for both total biofilm (p = 0.008) and viable biofilm (p = 0.005). no statistically significant difference was observed in biofilm biovolume (p = 0.082). Conclusions: These findings suggest that, despite the surface differences among the groups, biofilm formation was not significantly affected. Full article
(This article belongs to the Special Issue Advances in Antimicrobial Therapies for Oral Infections: From Biofilm Disruption to Clinical Applications)
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