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Hydrophobic Waters in Bromodomains

1
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Institute of Biomedicine of the University of Barcelona (IBUB), and Catalan Institution for Research and Advanced Studies (ICREA), 08028 Barcelona, Spain
2
Laboratory of Medicinal Chemistry (Associated Unit to CSIC), Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine of the University of Barcelona (IBUB), 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 80; https://doi.org/10.3390/proceedings2019022080
Published: 16 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [155 KB, uploaded 16 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

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Targeting epigenetic proteins is a rapidly growing area for medicinal chemistry and drug [...]
Keywords: bromodomains; BRD4; structural water molecules; fragment-based drug design; medicinal chemistry; crystallography; drug discovery bromodomains; BRD4; structural water molecules; fragment-based drug design; medicinal chemistry; crystallography; drug discovery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Piticchio, S.G.; Martínez-Cartró, M.; Scaffidi, S.; Rodríguez-Arévalo, S.; Bagán, A.; Sánchez-Arfelis, A.; Escolano, C.; Galdeano, C.; Barril, X. Hydrophobic Waters in Bromodomains. Proceedings 2019, 22, 80.

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