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Open AccessExtended Abstract

Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model

1
Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
2
Cardiac Research Laboratory, Felsenstein Research Center, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Petah Tikva 4910002, Israel
3
The Skin Research Institute, The Dead-Sea and Arava Science Center, Masada 86910, Israel
4
Department of Biopharmacy, Medical University of Lublin, 20-093 Lublin, Poland
5
Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 5290002, Israel
*
Author to whom correspondence should be addressed.
Proceedings 2019, 22(1), 72; https://doi.org/10.3390/proceedings2019022072
Published: 14 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [188 KB, uploaded 14 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

TLR4, a member of the toll-like receptors (TLRs) family, serves as a pattern recognition receptor in the innate immune response to different microbial pathogens. [...]
Keywords: peptidomimetics; cardioprotection; in silico modeling peptidomimetics; cardioprotection; in silico modeling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Trifonov, L.; Nudelman, V.; Zhenin, M.; Cohen, G.; Jozwiak, K.; Korshin, E.; Senderowitz, H.; Shainberg, A.; Hochhauser, E.; Gruzman, A. Peptidomimetic 1-Benzyl-5-methyl-4-(n-octylamino)pyrimidin-2(1H)-one Showed Cardioprotection Effect in a Myocardial Ischemia (MI) Mouse Model. Proceedings 2019, 22, 72.

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