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Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy

1
Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, 08907 L’Hospitalet de Llobregat, Spain
2
Department of Pharmacology and Medicinal Chemistry, Faculty of Pharmacy, and Institute of Biomedicine (IBUB), University of Barcelona, 08028 Barcelona, Spain
3
Institut D'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L’Hospitalet de Llobregat, Spain
4
Farmacologia Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 79; https://doi.org/10.3390/proceedings2019022079 (registering DOI)
Published: 16 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [135 KB, uploaded 16 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

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Phosphoenolpyruvate carboxykinase (PEPCK) is the key enzyme in gluconeogenesis/glyceroneogenesis, which catalyzes the decarboxylation of oxaloacetate to phosphoenolpyruvate. [...]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Aragó, M.; Rodríguez-Arévalo, S.; Hyrossova, P.; Moreno, J.; Abás, S.; Figueras, A.; Pérez, B.; Viñals, F.; Escolano, M.C.; Perales, J.C. Dibenzylxanthines as PPEPCK-M Inhibitors for Cancer Therapy. Proceedings 2019, 22, 79.

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