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Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry

1
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)—Helmholtz Centre for Infection Research (HZI), Department of Drug Design and Optimization, Campus Building E8.1, 66123 Saarbrücken, Germany
2
Department of Pharmacy, Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 81; https://doi.org/10.3390/proceedings2019022081
Published: 16 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [176 KB, uploaded 16 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

Antibiotic resistance is one of the biggest threats to humankind [1,2]. [...]
Keywords: methylerythritol phosphate pathway; DXS-enzyme; Protein templated dynamic combinatorial chemistry; anti-infectives (List three to ten pertinent keywords specific to the article; yet reasonably common within the subject discipline) methylerythritol phosphate pathway; DXS-enzyme; Protein templated dynamic combinatorial chemistry; anti-infectives (List three to ten pertinent keywords specific to the article; yet reasonably common within the subject discipline)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Jumde, R.P.; Alhayek, A.; Gierse, R.M.; Hirsch, A.K.H. Identification of Inhibitors of the Anti-Infective Target DXS Using Dynamic Combinatorial Chemistry. Proceedings 2019, 22, 81.

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