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Open AccessExtended Abstract

Synthesis, In Vitro Profiling, and In Vivo Efficacy Studies of a New Family of Multitarget Anti-Alzheimer Compounds

1
Laboratory of Pharmaceutical Chemistry (CSIC Associated Unit), Faculty of Pharmacy and Food Sciences, and Institute of Biomedicine (IBUB), University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain
2
Department of Biological Chemistry and Molecular Modeling, Instituto de Química Avanzada de Catalunya (IQAC-CSIC), C/Jordi Girona, 18-26, E-08034 Barcelona, Spain
3
Pathological Anatomy Unit, Pathology and Experimental Therapeutics Department, IDIBELL, and Neurosciencies Institute, University of Barcelona, and Biomedical Network Research Center on Neurodegenerative Diseases (CIBERNED), E-08907 L’Hospitalet de Llobregat, Spain
4
Pharmacology Unit, Pathology and Experimental Therapeutics Department, IDIBELL, and Neurosciencies Institute, University of Barcelona, E-08907 L’Hospitalet de Llobregat, Spain
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Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy
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Department for Life Quality Studies, University of Bologna, Corso d’Augusto 237, I-47921 Rimini, Italy
7
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, E-08028 Barcelona, Spain
8
Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences (Campus Torribera), and IBUB, University of Barcelona, Prat de la Riba 171, E-08921 Santa Coloma de Gramenet, Spain
9
Department of Pharmacology, Therapeutics and Toxicology, Autonomous University of Barcelona, E-08193 Bellaterra, Spain
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 71; https://doi.org/10.3390/proceedings2019022071
Published: 14 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
Note: In lieu of an abstract, this is an excerpt from the first page.

Simultaneous modulation of several targets or pathological events with a key pathogenic role is
a promising strategy to tackle thus far difficult-to-cure or incurable multifactorial diseases [...]
Keywords: multitarget compounds; multitarget-directed ligands; acetylcholinesterase inhibitors; butyrylcholinesterase inhibitors; BACE-1 inhibitors, anti-aggregating agents; antioxidant properties; brain permeability; in vivo efficacy studies. multitarget compounds; multitarget-directed ligands; acetylcholinesterase inhibitors; butyrylcholinesterase inhibitors; BACE-1 inhibitors, anti-aggregating agents; antioxidant properties; brain permeability; in vivo efficacy studies.
MDPI and ACS Style

Pérez-Areales, F.J.; Garrido, M.; Aso, E.; Bartolini, M.; Simone, A.D.; Espargaró, A.; Ginex, T.; Sabate, R.; Pérez, B.; Andrisano, V.; Luque, F.J.; Ferrer, I.; Ciruela, F.; Messeguer, A.; Muñoz-Torrero, D. Synthesis, In Vitro Profiling, and In Vivo Efficacy Studies of a New Family of Multitarget Anti-Alzheimer Compounds. Proceedings 2019, 22, 71.

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Proceedings, EISSN 2504-3900, Published by MDPI AG
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