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Open AccessAbstract

Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency

1
Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Rooms 10307, 10309, and 10315, 245 North 15th Street, Philadelphia, PA 19102, USA
2
GE Healthcare Life Sciences, 100 Results Way, Marlborough, MA 01752, USA
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 77; https://doi.org/10.3390/proceedings2019022077
Published: 15 August 2019
(This article belongs to the Proceedings of The Molecules Medicinal Chemistry Symposium)
PDF [147 KB, uploaded 15 August 2019]
Note: In lieu of an abstract, this is an excerpt from the first page.

Excerpt

The entry of HIV-1 into permissible cells remains an extremely attractive and underexploited
therapeutic intervention point [...]
Keywords: bioisosteres; HIV-1 Env; antiviral; surface plasmon resonance; computer-aided drug design bioisosteres; HIV-1 Env; antiviral; surface plasmon resonance; computer-aided drug design
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Meuser, M.E.; Murphy, M.B.; Rashad, A.A.; Cocklin, S. Kinetic Characterization of Novel HIV-1 Entry Inhibitors: Discovery of a Relationship between Off-Rate and Potency. Proceedings 2019, 22, 77.

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