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Abstract

Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors †

1
Normandie Univ, UNIROUEN, INSA Rouen, CNRS, COBRA (UMR 6014), 76000 Rouen, France
2
ICOA, UMR 7311 CNRS, Université d’Orléans, 45000 Orléans, France
3
UMR 1253, iBrain, Université de Tours, Inserm, 37000 Tours, France
*
Author to whom correspondence should be addressed.
Presented at the 2nd Molecules Medicinal Chemistry Symposium (MMCS): Facing Novel Challenges in Drug Discovery, Barcelona, Spain, 15–17 May 2019.
Proceedings 2019, 22(1), 88; https://doi.org/10.3390/proceedings2019022088
Published: 27 August 2019
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder. The available therapy is limited to symptomatic treatment, and its efficacy remains unsatisfactory. In view of the prevalence and expected increase in the incidence of AD, the development of an effective therapy is crucial for public health. Since the therapeutic paradigm “one compound–one-target” has shown its limits in the treatment of AD, new strategies are emerging to overcome the lack of efficiency of the current pharmacotherapy in the past decade. The most promising is the multitarget-directed ligands (MTDLs) strategy. This project consists of the development of new multifunctional agents, which will act simultaneously on the different players in AD pathology by combining an AChE inhibitory activity based on the structures of a well-known AChE inhibitor (Rivastigmine) with an α-7 nAChR activation. Indeed, nAChRs were recently put forward as potential targets for the treatment of central nervous system (CNS) diseases, such as AD. Because of their distribution and abundance in the CNS, the α-7 subtypes are potential therapeutic targets for this disorder.
Keywords: Alzheimer’s disease; Multitarget-Directed Ligand; AChE inhibitor; α-7 nAChR agonist Alzheimer’s disease; Multitarget-Directed Ligand; AChE inhibitor; α-7 nAChR agonist
MDPI and ACS Style

Pons, M.; Jean, L.; Routier, S.; Buron, F.; Chalon, S.; Renard, P.-Y. Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors. Proceedings 2019, 22, 88. https://doi.org/10.3390/proceedings2019022088

AMA Style

Pons M, Jean L, Routier S, Buron F, Chalon S, Renard P-Y. Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors. Proceedings. 2019; 22(1):88. https://doi.org/10.3390/proceedings2019022088

Chicago/Turabian Style

Pons, Mégane, Ludovic Jean, Sylvain Routier, Frédéric Buron, Sylvie Chalon, and Pierre-Yves Renard. 2019. "Toward an Innovative Treatment of Alzheimer’s Disease: Design of MTDLs Targeting Acetylcholinesterase and α-7 Nicotinic Receptors" Proceedings 22, no. 1: 88. https://doi.org/10.3390/proceedings2019022088

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