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Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications

Textile Engineering, Chemistry and Science Department, Wilson College of Textiles, NC State University, Raleigh, NC 27695, USA
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Bioengineering 2020, 7(3), 105; https://doi.org/10.3390/bioengineering7030105
Received: 29 July 2020 / Revised: 31 August 2020 / Accepted: 3 September 2020 / Published: 6 September 2020
(This article belongs to the Special Issue Cardiac Regeneration)
Tissue engineering (TE) combines cells, scaffolds, and growth factors to assemble functional tissues for repair or replacement of tissues and organs. Cardiac TE is focused on developing cardiac cells, tissues, and structures—most notably the heart. This review presents the requirements, challenges, and research surrounding electrospun scaffolds and induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs) towards applications to TE hearts. Electrospinning is an attractive fabrication method for cardiac TE scaffolds because it produces fibers that demonstrate the optimal potential for mimicking the complex structure of the cardiac extracellular matrix (ECM). iPSCs theoretically offer the capacity to generate limitless numbers of CMs for use in TE hearts, however these iPSC-CMs are electrophysiologically, morphologically, mechanically, and metabolically immature compared to adult CMs. This presents a functional limitation to their use in cardiac TE, and research aiming to address this limitation is presented in this review. View Full-Text
Keywords: tissue engineering; cardiac tissue engineering; engineered heart tissue; electrospinning; scaffolds; cardiomyocytes; induced pluripotent stem cells tissue engineering; cardiac tissue engineering; engineered heart tissue; electrospinning; scaffolds; cardiomyocytes; induced pluripotent stem cells
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Suh, T.C.; Amanah, A.Y.; Gluck, J.M. Electrospun Scaffolds and Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering Applications. Bioengineering 2020, 7, 105.

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