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Bioengineering, Volume 7, Issue 4

2020 December - 49 articles

Cover Story: Our nanocarriers are metal oxide nanoparticles encapsulated by a bilayer shell that allows the embedment of hydrophobic drugs. The first shell is formed by a hydrophobic phosphonic acid. The second shell is composed of an amphiphilic molecule that forms the bilayer via self-aggregation driven by hydrophobic interactions between their hydrophobic moiety and the hydrophobic first shell. The resulting double layer provides hydrophobic pockets for the intake of hydrophobic drugs. These nanocarriers were loaded with anticancer drugs and incorporated in cancer cells. Irradiation with X-rays released anticancer drugs into the cytoplasm and considerably decreased the survival rate of cancer cells. View this paper
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Articles (49)

  • Article
  • Open Access
12 Citations
3,976 Views
15 Pages

Osteons are the repeating unit throughout cortical bone, consisting of canals filled with blood and nerve vessels surrounded by concentric lamella of hydroxyapatite-containing collagen fibers, providing mechanical strength. Creating a biodegradable s...

  • Article
  • Open Access
26 Citations
7,059 Views
17 Pages

Recent advances in stem-cell technologies include the differentiation of human embryonic stem cells (hESCs) into organ-like structures (organoids). These organoids exhibit remarkable self-organization that resembles key aspects of in vivo organ devel...

  • Review
  • Open Access
51 Citations
7,788 Views
20 Pages

Engineered Collagen Matrices

  • Vaidehi A. Patil and
  • Kristyn S. Masters

Collagen is the most abundant protein in mammals, accounting for approximately one-third of the total protein in the human body. Thus, it is a logical choice for the creation of biomimetic environments, and there is a long history of using collagen m...

  • Article
  • Open Access
8 Citations
5,281 Views
24 Pages

Depletion of Boric Acid and Cobalt from Cultivation Media: Impact on Recombinant Protein Production with Komagataella phaffii

  • Alexander Pekarsky,
  • Sophia Mihalyi,
  • Maximilian Weiss,
  • Andreas Limbeck and
  • Oliver Spadiut

The REACH regulation stands for “Registration, Evaluation, Authorization and Restriction of Chemicals” and defines certain substances as harmful to human health and the environment. This urges manufacturers to adapt production processes....

  • Communication
  • Open Access
3 Citations
4,447 Views
13 Pages

Microfluidic Protein Imaging Platform: Study of Tau Protein Aggregation and Alzheimer’s Drug Response

  • Shubha Jain,
  • Sarpras Swain,
  • Lopamudra Das,
  • Sarita Swain,
  • Lopamudra Giri,
  • Anand Kumar Kondapi and
  • Harikrishnan Narayanan Unni

Tau protein aggregation is identified as one of the key phenomena associated with the onset and progression of Alzheimer’s disease. In the present study, we performed on-chip confocal imaging of tau protein aggregation and tau–drug intera...

  • Review
  • Open Access
91 Citations
10,495 Views
40 Pages

Future Perspectives in Small-Diameter Vascular Graft Engineering

  • Panagiotis Mallis,
  • Alkiviadis Kostakis,
  • Catherine Stavropoulos-Giokas and
  • Efstathios Michalopoulos

The increased demands of small-diameter vascular grafts (SDVGs) globally has forced the scientific society to explore alternative strategies utilizing the tissue engineering approaches. Cardiovascular disease (CVD) comprises one of the most lethal gr...

  • Article
  • Open Access
12 Citations
4,755 Views
12 Pages

Biomechanical Investigation of the Stomach Following Different Bariatric Surgery Approaches

  • Ilaria Toniolo,
  • Chiara Giulia Fontanella,
  • Mirto Foletto and
  • Emanuele Luigi Carniel

Background: The stomach is a hollow organ of the gastrointestinal tract, on which bariatric surgery (BS) is performed for the treatment of obesity. Even though BS is the most effective treatment for severe obesity, drawbacks and complications are sti...

  • Article
  • Open Access
9 Citations
5,802 Views
16 Pages

Background—Physiological helical flow in the ascending aorta has been well documented in the last two decades, accompanied by discussions on possible physiological benefits of such axial swirl. Recent 4D-MRI studies on healthy volunteers have f...

  • Editorial
  • Open Access
10 Citations
3,914 Views
3 Pages

Anaerobic Digestion in the 21st Century

  • Marcell Nikolausz and
  • Jörg Kretzschmar

Despite being a mature biotechnological process, anaerobic digestion is still attracting considerable research attention, mainly due to its versatility both in substrate and product spectra, as well as being a perfect test system for the microbial ec...

  • Review
  • Open Access
91 Citations
11,150 Views
26 Pages

Collagens provide the building blocks for diverse tissues and organs. Furthermore, these proteins act as signaling molecules that control cell behavior during organ development, growth, and repair. Their long half-life, mechanical strength, ability t...

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Bioengineering - ISSN 2306-5354