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Open AccessReview

Biomimetic Nanocarriers for Cancer Target Therapy

1
Department of Mathematics and Physics, University of Salento, Monteroni Street, 73100 Lecce, Italy
2
Nanotechnology Institute, CNR-NANOTEC, Monteroni Street, 73100 Lecce, Italy
3
Nanotechnology Institute, CNR-NANOTEC, c/o La Sapienza University, Piazzale A. Moro, 00185 Rome, Italy
*
Author to whom correspondence should be addressed.
Bioengineering 2020, 7(3), 111; https://doi.org/10.3390/bioengineering7030111
Received: 7 August 2020 / Revised: 3 September 2020 / Accepted: 11 September 2020 / Published: 14 September 2020
(This article belongs to the Collection Nanoparticles for Therapeutic and Diagnostic Applications)
Nanotechnology offers innovative tools for the design of biomimetic nanocarriers for targeted cancer therapy. These nano-systems present several advantages such as cargo’s protection and modulation of its release, inclusion of stimuli-responsive elements, and enhanced tumoral accumulation. All together, these nano-systems suffer low therapeutic efficacy in vivo because organisms can recognize and remove foreign nanomaterials. To overcome this important issue, different modifications on nanoparticle surfaces were exploited in order to reach the desired therapeutic efficacy eliciting, also, the response of immune system against cancer cells. For this reason, more recently, a new strategy involving cell membrane-covered nanoparticles for biomedical application has been attracting increasing attention. Membranes from red blood cells, platelets, leukocytes, tumor, and stem cells, have been exploited as biomimetic coatings of nanoparticles for evading clearance or stimulated immune system by maintaining in the same way their targeting capability. In this review, the use of different cell sources as coating of biomimetic nanocarriers for cancer therapy is discussed. View Full-Text
Keywords: biomimetic nanoparticles; cancer therapy; immunotherapy biomimetic nanoparticles; cancer therapy; immunotherapy
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Guido, C.; Maiorano, G.; Cortese, B.; D’Amone, S.; Palamà, I.E. Biomimetic Nanocarriers for Cancer Target Therapy. Bioengineering 2020, 7, 111.

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