Skip to Content

Bioengineering, Volume 11, Issue 9

2024 September - 94 articles

Cover Story: The primary method to assess sensitivity loss in diabetic foot is the 10 gf monofilament test. However, the process of manufacturing devices lacks regulation and proper calibration. In this work, monofilament behavior is modeled and compared with commercial devices to validate and evaluate accuracy in a clinical setting. Monofilament buckling and deflection are analytically modeled. Equipment that automates the metrological verification and calibration processes of monofilaments is described, and an evaluation of commercial devices is performed. The results show that the monofilament is sensitive to several variables that must be considered during manufacturing and use; otherwise, clinical decisions may compromised. The tests showed deviations from the 10 gf declared by the manufacturers. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (94)

  • Article
  • Open Access
5 Citations
1,969 Views
16 Pages

Genetic Algorithms for Feature Selection in the Classification of COVID-19 Patients

  • Cosimo Aliani,
  • Eva Rossi,
  • Mateusz Soliński,
  • Piergiorgio Francia,
  • Antonio Lanatà,
  • Teodor Buchner and
  • Leonardo Bocchi

Background: Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV-2) infection can cause feared consequences, such as affecting microcirculatory activity. The combined use of HRV analysis, genetic algorithms, and machine learning classifiers can...

  • Article
  • Open Access
1 Citations
1,811 Views
14 Pages

The registration of preoperative and follow-up brain MRI, which is crucial in illustrating patients’ responses to treatments and providing guidance for postoperative therapy, presents significant challenges. These challenges stem from the consi...

  • Article
  • Open Access
2 Citations
1,934 Views
14 Pages

FTSNet: Fundus Tumor Segmentation Network on Multiple Scales Guided by Classification Results and Prompts

  • Shurui Bai,
  • Zhuo Deng,
  • Jingyan Yang,
  • Zheng Gong,
  • Weihao Gao,
  • Lei Shao,
  • Fang Li,
  • Wenbin Wei and
  • Lan Ma

The segmentation of fundus tumors is critical for ophthalmic diagnosis and treatment, yet it presents unique challenges due to the variability in lesion size and shape. Our study introduces Fundus Tumor Segmentation Network (FTSNet), a novel segmenta...

  • Article
  • Open Access
3 Citations
2,334 Views
16 Pages

Machine Learning and Optical-Coherence-Tomography-Derived Radiomics Analysis to Predict the Postoperative Anatomical Outcome of Full-Thickness Macular Hole

  • Yuqian Hu,
  • Yongan Meng,
  • Youling Liang,
  • Yiwei Zhang,
  • Biying Chen,
  • Jianing Qiu,
  • Zhishang Meng and
  • Jing Luo

Full-thickness macular hole (FTMH) leads to central vision loss. It is essential to identify patients with FTMH at high risk of postoperative failure accurately to achieve anatomical closure. This study aimed to construct a predictive model for the a...

  • Article
  • Open Access
2 Citations
2,708 Views
15 Pages

Comparing Isolated Thumb Force Generation, Wrist Rotation, and Clinical Measurements in Healthy and Osteoarthritic Individuals before and after Surgery

  • Nicole Arnold,
  • Adam Chrzan,
  • Kevin Chan,
  • Daniel Hess,
  • Levi Hinkleman,
  • Stephen Duquette,
  • John Kelpin and
  • Tamara Reid Bush

Thumb carpometacarpal (CMC) osteoarthritis (OA) is caused by the degeneration of joint surfaces at the base of the thumb. If conservative treatments have failed, surgery may be needed to improve symptoms. Typically, standard clinical tools, such as t...

  • Article
  • Open Access
1 Citations
3,443 Views
23 Pages

Mesenchymal Stem Cell-Conditioned Media-Loaded Microparticles Enhance Acute Patency in Silk-Based Vascular Grafts

  • Katherine L. Lorentz,
  • Ande X. Marini,
  • Liza A. Bruk,
  • Prerak Gupta,
  • Biman B. Mandal,
  • Morgan V. DiLeo,
  • Justin S. Weinbaum,
  • Steven R. Little and
  • David A. Vorp

Coronary artery disease leads to over 360,000 deaths annually in the United States, and off-the-shelf bypass graft options are currently limited and/or have high failure rates. Tissue-engineered vascular grafts (TEVGs) present an attractive option, t...

  • Article
  • Open Access
4 Citations
4,025 Views
28 Pages

A 3D Epithelial–Mesenchymal Co-Culture Model of the Airway Wall Using Native Lung Extracellular Matrix

  • Roderick H. J. de Hilster,
  • Marjan A. Reinders-Luinge,
  • Annemarie Schuil,
  • Theo Borghuis,
  • Martin C. Harmsen,
  • Janette K. Burgess and
  • Machteld N. Hylkema

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by ongoing inflammation, impaired tissue repair, and aberrant interplay between airway epithelium and fibroblasts, resulting in an altered extracellular matrix (ECM)...

  • Article
  • Open Access
21 Citations
4,605 Views
24 Pages

EfficientUNetViT: Efficient Breast Tumor Segmentation Utilizing UNet Architecture and Pretrained Vision Transformer

  • Shokofeh Anari,
  • Gabriel Gomes de Oliveira,
  • Ramin Ranjbarzadeh,
  • Angela Maria Alves,
  • Gabriel Caumo Vaz and
  • Malika Bendechache

This study introduces a sophisticated neural network structure for segmenting breast tumors. It achieves this by combining a pretrained Vision Transformer (ViT) model with a UNet framework. The UNet architecture, commonly employed for biomedical imag...

  • Article
  • Open Access
5 Citations
1,983 Views
15 Pages

Improvement in Image Quality of Low-Dose CT of Canines with Generative Adversarial Network of Anti-Aliasing Generator and Multi-Scale Discriminator

  • Yuseong Son,
  • Sihyeon Jeong,
  • Youngtaek Hong,
  • Jina Lee,
  • Byunghwan Jeon,
  • Hyunji Choi,
  • Jaehwan Kim and
  • Hackjoon Shim

Computed tomography (CT) imaging is vital for diagnosing and monitoring diseases in both humans and animals, yet radiation exposure remains a significant concern, especially in animal imaging. Low-dose CT (LDCT) minimizes radiation exposure but often...

  • Article
  • Open Access
3 Citations
4,242 Views
15 Pages

Background: Alzheimer’s disease (AD) is a leading cause of dementia, and it is significantly influenced by the apolipoprotein E4 (APOE4) gene and gender. This study aimed to use machine learning (ML) algorithms to predict brain age and assess A...

  • Article
  • Open Access
6 Citations
2,623 Views
19 Pages

AI-Powered Telemedicine for Automatic Scoring of Neuromuscular Examinations

  • Quentin Lesport,
  • Davis Palmie,
  • Gülşen Öztosun,
  • Henry J. Kaminski and
  • Marc Garbey

Telemedicine is now being used more frequently to evaluate patients with myasthenia gravis (MG). Assessing this condition involves clinical outcome measures, such as the standardized MG-ADL scale or the more complex MG-CE score obtained during clinic...

  • Article
  • Open Access
2 Citations
2,293 Views
21 Pages

Accurate registration between medical images and patient anatomy is crucial for surgical navigation systems in minimally invasive surgeries. This study introduces a novel deep learning-based refinement step to enhance the accuracy of surface registra...

  • Article
  • Open Access
14 Citations
5,222 Views
12 Pages

Segment Anything in Optical Coherence Tomography: SAM 2 for Volumetric Segmentation of Retinal Biomarkers

  • Mikhail Kulyabin,
  • Aleksei Zhdanov,
  • Andrey Pershin,
  • Gleb Sokolov,
  • Anastasia Nikiforova,
  • Mikhail Ronkin,
  • Vasilii Borisov and
  • Andreas Maier

Optical coherence tomography (OCT) is a non-invasive imaging technique widely used in ophthalmology for visualizing retinal layers, aiding in the early detection and monitoring of retinal diseases. OCT is useful for detecting diseases such as age-rel...

  • Article
  • Open Access
4 Citations
2,920 Views
11 Pages

Background: To evaluate the clinical outcomes and patient satisfaction after implantation of an enhanced monofocal intraocular lens (TECNIS Eyhance ICB00) in patients with idiopathic epiretinal membrane (ERM) who underwent cataract surgery with pars...

  • Article
  • Open Access
2 Citations
1,623 Views
11 Pages

Total knee arthroplasty (TKA) is a commonly performed surgery aimed at alleviating pain and improving functionality. However, patients often face uncertainties in selecting the timing, location, and type of TKA implant that best meets their needs. Th...

  • Review
  • Open Access
21 Citations
20,921 Views
20 Pages

The Use of Artificial Intelligence in Caries Detection: A Review

  • Khalifa S. Al-Khalifa,
  • Walaa Magdy Ahmed,
  • Amr Ahmed Azhari,
  • Masoumah Qaw,
  • Rasha Alsheikh,
  • Fatema Alqudaihi and
  • Amal Alfaraj

Advancements in artificial intelligence (AI) have significantly impacted the field of dentistry, particularly in diagnostic imaging for caries detection. This review critically examines the current state of AI applications in caries detection, focusi...

  • Review
  • Open Access
20 Citations
16,281 Views
37 Pages

Toward Digital Periodontal Health: Recent Advances and Future Perspectives

  • Fatemeh Soheili,
  • Niloufar Delfan,
  • Negin Masoudifar,
  • Shahin Ebrahimni,
  • Behzad Moshiri,
  • Michael Glogauer and
  • Ebrahim Ghafar-Zadeh

Periodontal diseases, ranging from gingivitis to periodontitis, are prevalent oral diseases affecting over 50% of the global population. These diseases arise from infections and inflammation of the gums and supporting bones, significantly impacting o...

  • Article
  • Open Access
10 Citations
3,675 Views
21 Pages

Vine shoots hold promise as a biomass source for fermentable sugars with efficient fractionation and conversion processes. The study explores vine shoots as a biomass source for fermentable sugars through pretreatment with two deep eutectic solvents...

  • Article
  • Open Access
1 Citations
2,155 Views
18 Pages

Tailoring Plasmonic Nanoheaters Size for Enhanced Theranostic Agent Performance

  • Túlio de L. Pedrosa,
  • Gabrielli M. F. de Oliveira,
  • Arthur C. M. V. Pereira,
  • Mariana J. B. da S. Crispim,
  • Luzia A. da Silva,
  • Marcilene S. da Silva,
  • Ivone A. de Souza,
  • Ana M. M. de A. Melo,
  • Anderson S. L. Gomes and
  • Renato E. de Araujo

The introduction of optimized nanoheaters, which function as theranostic agents integrating both diagnostic and therapeutic processes, holds significant promise in the medical field. Therefore, developing strategies for selecting and utilizing optimi...

  • Review
  • Open Access
3 Citations
3,546 Views
30 Pages

Artifact Management for Cerebral Near-Infrared Spectroscopy Signals: A Systematic Scoping Review

  • Tobias Bergmann,
  • Nuray Vakitbilir,
  • Alwyn Gomez,
  • Abrar Islam,
  • Kevin Y. Stein,
  • Amanjyot Singh Sainbhi,
  • Logan Froese and
  • Frederick A. Zeiler

Artifacts induced during patient monitoring are a main limitation for near-infrared spectroscopy (NIRS) as a non-invasive method of cerebral hemodynamic monitoring. There currently does not exist a robust “gold-standard” method for artifa...

  • Article
  • Open Access
2 Citations
2,540 Views
26 Pages

The task of localizing distinct anatomical structures in medical image data is an essential prerequisite for several medical applications, such as treatment planning in orthodontics, bone-age estimation, or initialization of segmentation methods in a...

  • Article
  • Open Access
4 Citations
2,613 Views
20 Pages

Inositol hexakisphosphate (InsP6) is the most abundant inositol polyphosphate both in plant and animal cells. Exogenous InsP6 is known to inhibit cell proliferation and induce apoptosis in cancerous cells. However, cellular entry of exogenous InsP6 i...

  • Article
  • Open Access
3 Citations
2,393 Views
21 Pages

ABNet: AI-Empowered Abnormal Action Recognition Method for Laboratory Mouse Behavior

  • Yuming Chen,
  • Chaopeng Guo,
  • Yue Han,
  • Shuang Hao and
  • Jie Song

The automatic recognition and quantitative analysis of abnormal behavior in mice play a crucial role in behavioral observation experiments in neuroscience, pharmacology, and toxicology. Due to the challenging definition of abnormal behavior and diffi...

  • Article
  • Open Access
1 Citations
1,306 Views
10 Pages

Ortho-R (ChitogenX Inc., Kirkland, QC, Canada) is an injectable combination drug–biologic product that is used as an adjunct to augment the standard of care for the surgical repair of soft tissues. The drug product comprises lyophilized chitosa...

  • Article
  • Open Access
7 Citations
2,591 Views
10 Pages

Sequential drilling is a common practice in dental implant surgery aimed at minimizing thermal damage to bone. This study evaluates the thermal effects of sequential drilling and assesses modifications to drilling protocols to manage heat generation....

  • Article
  • Open Access
1 Citations
2,214 Views
13 Pages

Machine Learning Algorithm for Predicting Distant Metastasis of T1 and T2 Gallbladder Cancer Based on SEER Database

  • Zhentian Guo,
  • Zongming Zhang,
  • Limin Liu,
  • Yue Zhao,
  • Zhuo Liu,
  • Chong Zhang,
  • Hui Qi,
  • Jinqiu Feng,
  • Peijie Yao and
  • Haiming Yuan

(1) Background: This study seeks to employ a machine learning (ML) algorithm to forecast the risk of distant metastasis (DM) in patients with T1 and T2 gallbladder cancer (GBC); (2) Methods: Data of patients diagnosed with T1 and T2 GBC was obtained...

  • Article
  • Open Access
1 Citations
1,797 Views
18 Pages

Research on electroencephalogram-based motor imagery (MI-EEG) can identify the limbs of subjects that generate motor imagination by decoding EEG signals, which is an important issue in the field of brain–computer interface (BCI). Existing deep-...

  • Article
  • Open Access
8 Citations
5,078 Views
18 Pages

Innovative PEEK in Dentistry of Enhanced Adhesion and Sustainability through AI-Driven Surface Treatments

  • Mattew A. Olawumi,
  • Francis T. Omigbodun,
  • Bankole I. Oladapo,
  • Temitope Olumide Olugbade and
  • David B. Olawade

This research investigates using Polyether ether ketone (PEEK) in dental prosthetics, focusing on enhancing the mechanical properties, adhesion capabilities, and environmental sustainability through AI-driven data analysis and advanced surface treatm...

  • Article
  • Open Access
1 Citations
2,870 Views
12 Pages

Background: The objective of this study was to evaluate how effectively the bioelectric toothbrush can alleviate dentin hypersensitivity (DHS) by using electrostatic forces to remove biofilm from the tooth surface. Methods: This study divided inpatie...

  • Article
  • Open Access
1 Citations
1,442 Views
9 Pages

Orbital Adipose Tissue: The Optimal Control for Back-Table Fluorescence Imaging of Orbital Tumors

  • Lan Yao,
  • Wenhua Zhang,
  • Xuedong Wang,
  • Lishuang Guo,
  • Wenlu Liu,
  • Yueyue Li,
  • Rui Ma,
  • Yan Hei,
  • Xinji Yang and
  • Wei Wu
  • + 1 author

Control tissue is essential for ensuring the precision of semiquantitative analysis in back-table fluorescence imaging. However, there remains a lack of agreement on the appropriate selection of control tissues. To evaluate the back-table fluorescenc...

  • Article
  • Open Access
2 Citations
2,377 Views
16 Pages

(1) Background: Various machine learning techniques were used to predict hypertension in Korean adults aged 20 and above, using a range of body composition indicators. Muscle and fat components of body composition are closely related to hypertension....

  • Article
  • Open Access
4 Citations
2,587 Views
19 Pages

Comparison of Bioengineered Scaffolds for the Induction of Osteochondrogenic Differentiation of Human Adipose-Derived Stem Cells

  • Elena Fiorelli,
  • Maria Giovanna Scioli,
  • Sonia Terriaca,
  • Arsalan Ul Haq,
  • Gabriele Storti,
  • Marta Madaghiele,
  • Valeria Palumbo,
  • Ermal Pashaj,
  • Fabio De Matteis and
  • Augusto Orlandi
  • + 2 authors

Osteochondral lesions may be due to trauma or congenital conditions. In both cases, therapy is limited because of the difficulty of tissue repair. Tissue engineering is a promising approach that relies on designed scaffolds with variable mechanical a...

  • Article
  • Open Access
1 Citations
2,247 Views
17 Pages

Impact of Uniaxial Static Strain on Myoblast Differentiation in Collagen-Coated PCL Microfilament Scaffolds: Role of Onset Time of Mechanical Stimulation

  • María Laura Espinoza-Álvarez,
  • Laura Rojas-Rojas,
  • Johan Morales-Sánchez and
  • Teodolito Guillén-Girón

Tissue engineering endeavors to create in vitro constructs that replicate the properties of native tissue, such as skeletal muscle. This study investigated the use of mechanical stimulation to promote myogenic differentiation and enhance the function...

  • Article
  • Open Access
4 Citations
4,428 Views
23 Pages

Although the finite element head model (FEHM) has been widely utilized to analyze injury locations and patterns in traumatic brain injury, significant controversy persists regarding the selection of a mechanical injury variable and its corresponding...

  • Article
  • Open Access
2 Citations
3,831 Views
8 Pages

Noninvasive brain signal measurement techniques are crucial for understanding human brain function and brain–machine interface applications. Conventionally, noninvasive brain signal measurement techniques, such as electroencephalography, magnet...

  • Article
  • Open Access
3 Citations
1,988 Views
14 Pages

The human brain is a complex organ controlling daily activity. Present technique models have mostly focused on multi-layer brain tissues, which lack understanding of the propagation characteristics of various single brain tissues. To better understan...

  • Article
  • Open Access
2 Citations
2,231 Views
24 Pages

Computational Modeling Approach to Profile Hemodynamical Behavior in a Healthy Aorta

  • Ahmed M. Al-Jumaily,
  • Mohammad Al-Rawi,
  • Djelloul Belkacemi,
  • Radu Andy Sascău,
  • Cristian Stătescu,
  • Florin-Emilian Țurcanu and
  • Larisa Anghel

Cardiovascular diseases (CVD) remain the leading cause of mortality among older adults. Early detection is critical as the prognosis for advanced-stage CVD is often poor. Consequently, non-invasive diagnostic tools that can assess hemodynamic functio...

  • Article
  • Open Access
3 Citations
5,615 Views
13 Pages

Oral cancer, also known as oral squamous cell carcinoma (OSCC), is one of the most prevalent types of cancer and caused 177,757 deaths worldwide in 2020, as reported by the World Health Organization. Early detection and identification of OSCC are hig...

  • Review
  • Open Access
15 Citations
5,932 Views
40 Pages

Optical Image Sensors for Smart Analytical Chemiluminescence Biosensors

  • Reza Abbasi,
  • Xinyue Hu,
  • Alain Zhang,
  • Isabelle Dummer and
  • Sebastian Wachsmann-Hogiu

Optical biosensors have emerged as a powerful tool in analytical biochemistry, offering high sensitivity and specificity in the detection of various biomolecules. This article explores the advancements in the integration of optical biosensors with mi...

  • Article
  • Open Access
13 Citations
9,656 Views
18 Pages

Biomechanical Gait Analysis Using a Smartphone-Based Motion Capture System (OpenCap) in Patients with Neurological Disorders

  • Yu-Sun Min,
  • Tae-Du Jung,
  • Yang-Soo Lee,
  • Yonghan Kwon,
  • Hyung Joon Kim,
  • Hee Chan Kim,
  • Jung Chan Lee and
  • Eunhee Park

This study evaluates the utility of OpenCap (v0.3), a smartphone-based motion capture system, for performing gait analysis in patients with neurological disorders. We compared kinematic and kinetic gait parameters between 10 healthy controls and 10 p...

  • Review
  • Open Access
2 Citations
2,060 Views
12 Pages

Current surgical practices in total knee arthroplasty (TKA) have advanced and include significant changes and improvements in alignment philosophies, femorotibial implant conformities, and ligament management to replicate in vivo knee kinematics. Whi...

  • Article
  • Open Access
7 Citations
2,340 Views
15 Pages

NMGrad: Advancing Histopathological Bladder Cancer Grading with Weakly Supervised Deep Learning

  • Saul Fuster,
  • Umay Kiraz,
  • Trygve Eftestøl,
  • Emiel A. M. Janssen and
  • Kjersti Engan

The most prevalent form of bladder cancer is urothelial carcinoma, characterized by a high recurrence rate and substantial lifetime treatment costs for patients. Grading is a prime factor for patient risk stratification, although it suffers from inco...

  • Article
  • Open Access
2 Citations
2,337 Views
18 Pages

Optimizing Fall Risk Diagnosis in Older Adults Using a Bayesian Classifier and Simulated Annealing

  • Enrique Hernandez-Laredo,
  • Ángel Gabriel Estévez-Pedraza,
  • Laura Mercedes Santiago-Fuentes and
  • Lorena Parra-Rodríguez

The aim of this study was to improve the diagnostic ability of fall risk classifiers using a Bayesian approach and the Simulated Annealing (SA) algorithm. A total of 47 features from 181 records (40 Center of Pressure (CoP) indices and 7 patient desc...

  • Article
  • Open Access
3 Citations
3,331 Views
13 Pages

Meibomian Gland Dysfunction and Dropout in Diabetic Patients with Non-Proliferative Diabetic Retinopathy

  • Karim Mohamed-Noriega,
  • Carla Sofía González-Arocha,
  • Fernando Morales-Wong,
  • Braulio Hernán Velasco-Sepúlveda,
  • Jonathan Octavio Rodríguez-Cuevas,
  • Gerardo Esteban Cepeda-Ortegón,
  • Sergio Antonio Corral-Benavides,
  • José Francisco Martínez-Delgado,
  • Jibran Mohamed-Noriega and
  • Jesús Mohamed-Hamsho
  • + 1 author

This study aims to compare meibomian gland (MG) dropout and MG dysfunction (MGD) between patients with diabetes mellitus (DM) with moderate–severe non-proliferative diabetic retinopathy (NPDR) and patients with no diabetes (NDM). This prospecti...

  • Article
  • Open Access
2 Citations
2,301 Views
13 Pages

The mainstream compartmental models require stochastic parameterization to estimate the transmission parameters between compartments, whose calculation depend upon detailed statistics on epidemiological characteristics, which are expensive, economica...

  • Review
  • Open Access
1 Citations
2,212 Views
13 Pages

Identification of Pain through Actigraphy-Recorded Patient Movement: A Comprehensive Review

  • Ricardo A. Torres-Guzman,
  • Olivia A. Ho,
  • Sahar Borna,
  • Cesar A. Gomez-Cabello,
  • Syed Ali Haider and
  • Antonio Jorge Forte

Chronic pain affects over 50 million people in the United States, particularly older adults, making effective assessment and treatment essential in primary care. Actigraphy, which monitors and records limb movement to estimate wakefulness and sleep,...

  • Article
  • Open Access
2 Citations
2,943 Views
13 Pages

Using Electrical Muscle Stimulation to Enhance Electrophysiological Performance of Agonist–Antagonist Myoneural Interface

  • Jianping Huang,
  • Ping Wang,
  • Wei Wang,
  • Jingjing Wei,
  • Lin Yang,
  • Zhiyuan Liu and
  • Guanglin Li

The agonist–antagonist myoneural interface (AMI), a surgical method to reinnervate physiologically-relevant proprioceptive feedback for control of limb prostheses, has demonstrated the ability to provide natural afferent sensations for limb amp...

  • Article
  • Open Access
6 Citations
2,080 Views
13 Pages

Early diagnosis of paroxysmal atrial fibrillation (PAF) could prompt patients to receive timely interventions in clinical practice. Various PAF onset prediction algorithms might benefit from accurate heart rate variability (HRV) analysis and machine...

of 2

XFacebookLinkedIn
Bioengineering - ISSN 2306-5354