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Bioengineering
Special Issues
Advanced Manufacturing and Biomaterials for Tissue Engineering and Regenerative Medicine
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Advanced Manufacturing and Biomaterials for Tissue Engineering and Regenerative Medicine

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: 31 December 2024 | Viewed by 5711

Special Issue Editor

Dr. Roozbeh Ross Salary

E-Mail Website
Guest Editor
Weisberg Department of Mechanical Engineering, Marshall University (West Virginia State), Huntington, WV, USA
Interests: advanced manufacturing; tissue engineering; regenerative medicine; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of tissue and regenerative engineering has been changing rapidly. Advanced manufacturing, biomaterials, as well as stem cell engineering are, doubtlessly, integral parts of tissues regeneration, paving the way for direct organ biofabrication and regeneration in the future. These areas are intrinsically complex and thus require rigorously implemented, multidisciplinary research to achieve the desired patient-specific outcomes. The objective of this joint Special Issue is to presnet a collection of cutting-edge research works from a broad range of related topics that can address the current challenges and potentially transform the status quo of regenerative engineering. Researchers and scholars from the industry, academia, and government are invited to submit full research and/or review papers to this Special Issue, which will focus on advanced manufacturing, biomaterials, and stem cells for tissue and regenerative engineering. The topics covered in this Special Issue include but are not limited to:

  • 3D/4D biomanufacturing and biofabrication;
  • Synthesis and characterization of tissues and organs, including in vivo and clinical studies;
  • Natural origin, synthetic, and composite materials;
  • Stem cell engineering;
  • Cell-extracellular matrix interactions in regeneration;
  • Mechanical determinants of tissue development and repair;
  • Biomechanics and mechanobiology modeling;
  • Applications of nanotechnology for regenerative medicine;
  • Body-on-a-chip for regenerative medicine;
  • Bioreactors in regenerative medicine;
  • Artificial intelligence (AI)- enabled tissue and regenerative engineering.

You may choose our Joint Special Issue in Machines.

Dr. Roozbeh Ross Salary
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • advanced manufacturing
  • biomaterials
  • tissue engineering
  • regenerative medicine

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (3 papers)

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Research

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15 pages, 2090 KiB  
Article
Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes
by Yize Zhang and Samira Musah
Bioengineering 2024, 11(10), 1038; https://doi.org/10.3390/bioengineering11101038 - 17 Oct 2024
Viewed by 1134
Abstract
Stem cell fate decisions, including proliferation, differentiation, morphological changes, and viability, are impacted by microenvironmental cues such as physical and biochemical signals. However, the specific impact of matrix elasticity on kidney cell development and function remains less understood due to the lack of [...] Read more.
Stem cell fate decisions, including proliferation, differentiation, morphological changes, and viability, are impacted by microenvironmental cues such as physical and biochemical signals. However, the specific impact of matrix elasticity on kidney cell development and function remains less understood due to the lack of models that can closely recapitulate human kidney biology. An established protocol to differentiate podocytes from human-induced pluripotent stem (iPS) cells provides a promising avenue to elucidate the role of matrix elasticity in kidney tissue development and lineage determination. In this study, we synthesized polyacrylamide hydrogels with different stiffnesses and investigated their ability to promote podocyte differentiation and biomolecular characteristics. We found that 3 kPa and 10 kPa hydrogels significantly support the adhesion, differentiation, and viability of podocytes. Differentiating podocytes on a more compliant (0.7 kPa) hydrogel resulted in significant cell loss and detachment. Further investigation of the mechanosensitive proteins yes-associated protein (YAP) and synaptopodin revealed nuanced molecular distinctions in cellular responses to matrix elasticity that may otherwise be overlooked if morphology and cell spreading alone were used as the primary metric for selecting matrices for podocyte differentiation. Specifically, hydrogels with kidney-like rigidities outperformed traditional tissue culture plates at modulating the molecular-level expression of active mechanosensitive proteins critical for podocyte health and function. These findings could guide the development of physiologically relevant platforms for kidney tissue engineering, disease modeling, and mechanistic studies of organ physiology and pathophysiology. Such advances are critical for realizing the full potential of in vitro platforms in accurately predicting human biological responses. Full article
(This article belongs to the Special Issue Advanced Manufacturing and Biomaterials for Tissue Engineering and Regenerative Medicine)
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18 pages, 3680 KiB  
Article
Innovative PEEK in Dentistry of Enhanced Adhesion and Sustainability through AI-Driven Surface Treatments
by Mattew A. Olawumi, Francis T. Omigbodun, Bankole I. Oladapo, Temitope Olumide Olugbade and David B. Olawade
Bioengineering 2024, 11(9), 924; https://doi.org/10.3390/bioengineering11090924 - 14 Sep 2024
Cited by 1 | Viewed by 1391
Abstract
This research investigates using Polyether ether ketone (PEEK) in dental prosthetics, focusing on enhancing the mechanical properties, adhesion capabilities, and environmental sustainability through AI-driven data analysis and advanced surface treatments. The objectives include improving PEEK’s adhesion to dental types of cement, assessing its [...] Read more.
This research investigates using Polyether ether ketone (PEEK) in dental prosthetics, focusing on enhancing the mechanical properties, adhesion capabilities, and environmental sustainability through AI-driven data analysis and advanced surface treatments. The objectives include improving PEEK’s adhesion to dental types of cement, assessing its biocompatibility, and evaluating its environmental impact compared to traditional materials. The methodologies employed involve surface treatments such as plasma treatment and chemical etching, mechanical testing under ASTM standards, biocompatibility assessments, and lifecycle analysis. AI models predict and optimize mechanical properties based on extensive data. Significant findings indicate that surface-treated PEEK exhibits superior adhesion properties, maintaining robust mechanical integrity with no cytotoxic effects and supporting its use in direct contact with human tissues. Lifecycle analysis suggests PEEK offers a reduced environmental footprint due to lower energy-intensive production processes and recyclability. AI-driven analysis further enhances the material’s performance prediction and optimization, ensuring better clinical outcomes. The study concludes that with improved surface treatments and AI optimization, PEEK is a promising alternative to conventional dental materials, combining enhanced performance with environmental sustainability, paving the way for broader acceptance in dental applications. Full article
(This article belongs to the Special Issue Advanced Manufacturing and Biomaterials for Tissue Engineering and Regenerative Medicine)
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Review

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16 pages, 1028 KiB  
Review
Orthobiologic Management Options for Degenerative Disc Disease
by Cezar Augusto Alves de Oliveira, Bernardo Scaldini Oliveira, Rafael Theodoro, Joshua Wang, Gabriel Silva Santos, Bruno Lima Rodrigues, Izair Jefthé Rodrigues, Daniel de Moraes Ferreira Jorge, Madhan Jeyaraman, Peter Albert Everts, Annu Navani and José Fábio Lana
Bioengineering 2024, 11(6), 591; https://doi.org/10.3390/bioengineering11060591 - 10 Jun 2024
Viewed by 2242
Abstract
Degenerative disc disease (DDD) is a pervasive condition that limits quality of life and burdens economies worldwide. Conventional pharmacological treatments primarily aimed at slowing the progression of degeneration have demonstrated limited long-term efficacy and often do not address the underlying causes of the [...] Read more.
Degenerative disc disease (DDD) is a pervasive condition that limits quality of life and burdens economies worldwide. Conventional pharmacological treatments primarily aimed at slowing the progression of degeneration have demonstrated limited long-term efficacy and often do not address the underlying causes of the disease. On the other hand, orthobiologics are regenerative agents derived from the patient’s own tissue and represent a promising emerging therapy for degenerative disc disease. This review comprehensively outlines the pathophysiology of DDD, highlighting the inadequacies of existing pharmacological therapies and detailing the potential of orthobiologic approaches. It explores advanced tools such as platelet-rich plasma and mesenchymal stem cells, providing a historical overview of their development within regenerative medicine, from foundational in vitro studies to preclinical animal models. Moreover, the manuscript delves into clinical trials that assess the effectiveness of these therapies in managing DDD. While the current clinical evidence is promising, it remains insufficient for routine clinical adoption due to limitations in study designs. The review emphasizes the need for further research to optimize these therapies for consistent and effective clinical outcomes, potentially revolutionizing the management of DDD and offering renewed hope for patients. Full article
(This article belongs to the Special Issue Advanced Manufacturing and Biomaterials for Tissue Engineering and Regenerative Medicine)
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