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Bioengineering, Volume 11, Issue 8

2024 August - 119 articles

Cover Story: The administration of oxygen microbubbles (OMBs) has been shown to increase oxygen and decrease carbon dioxide in systemic circulation. However, their impact on microenvironmental oxygenation remains unexplored. Herein, we investigated the effects of intraperitoneal administration of OMBs in anesthetized rats exposed to hypoxic ventilation. Blood oxygenation and hemodynamics were evaluated over a 2 h time frame. Tissue samples were collected for hypoxic and metabolic analyses. Data show that OMBs improved blood SaO2 and alleviated tissue hypoxia. Metabolomic analysis revealed OMBs induced metabolic differences in all organs analyzed, with the greatest effects on the spleen and lung. In summary, intraperitoneal OMBs improve systemic blood and local tissue oxygenation, thereby shifting metabolomic profiles. View this paper
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Articles (119)

  • Article
  • Open Access
6 Citations
2,638 Views
13 Pages

Contrast-Enhancing Lesion Segmentation in Multiple Sclerosis: A Deep Learning Approach Validated in a Multicentric Cohort

  • Martina Greselin,
  • Po-Jui Lu,
  • Lester Melie-Garcia,
  • Mario Ocampo-Pineda,
  • Riccardo Galbusera,
  • Alessandro Cagol,
  • Matthias Weigel,
  • Nina de Oliveira Siebenborn,
  • Esther Ruberte and
  • Cristina Granziera
  • + 28 authors

The detection of contrast-enhancing lesions (CELs) is fundamental for the diagnosis and monitoring of patients with multiple sclerosis (MS). This task is time-consuming and suffers from high intra- and inter-rater variability in clinical practice. Ho...

  • Article
  • Open Access
1 Citations
1,661 Views
13 Pages

(1) Background: The kinematic characteristics of disc prosthesis undergoing complex motion are not well understood. Therefore, examining complex motion may provide an improved understanding of the post-operative behavior of spinal implants. (2) Metho...

  • Review
  • Open Access
1 Citations
1,827 Views
14 Pages

More than three decades ago, we embarked on a number of bioengineering explorations using the most advanced materials and fabrication methods. In every area we ventured into, it was our intention to ensure fundamental discoveries were deployed into t...

  • Article
  • Open Access
6 Citations
2,215 Views
11 Pages

Antimicrobial peptides (AMPs) are considered a promising alternative to conventional antibiotics to fight against the rapid evolution of antibiotic resistance. Other than their potent antimicrobial properties, AMP-based vesicles can be used as effici...

  • Article
  • Open Access
6 Citations
3,329 Views
18 Pages

Bovine Placentome-Derived Extracellular Matrix: A Sustainable 3D Scaffold for Cultivated Meat

  • Cemile Bektas,
  • Kathleen Lee,
  • Anisha Jackson,
  • Mohit Bhatia and
  • Yong Mao

Cultivated meat, an advancement in cellular agriculture, holds promise in addressing environmental, ethical, and health challenges associated with traditional meat production. Utilizing tissue engineering principles, cultivated meat production employ...

  • Article
  • Open Access
3 Citations
4,712 Views
18 Pages

Background: Our study addresses the lack of consensus on measuring leg length discrepancy (LLD) after total hip arthroplasty (THA). We will assess the inter-observer variability and correlation between the five most commonly used LLD methods and inve...

  • Article
  • Open Access
4 Citations
3,651 Views
18 Pages

The fallopian tubes are essential for human fertility, facilitating the movement of sperm and oocytes to the fertilization site and transporting fertilized oocytes to the uterus. Infertility can result from changes in the fallopian tubes due to tubal...

  • Article
  • Open Access
6 Citations
4,352 Views
20 Pages

3D Quantitative-Amplified Magnetic Resonance Imaging (3D q-aMRI)

  • Itamar Terem,
  • Kyan Younes,
  • Nan Wang,
  • Paul Condron,
  • Javid Abderezaei,
  • Haribalan Kumar,
  • Hillary Vossler,
  • Eryn Kwon,
  • Mehmet Kurt and
  • Kawin Setsompop
  • + 2 authors

Amplified MRI (aMRI) is a promising new technique that can visualize pulsatile brain tissue motion by amplifying sub-voxel motion in cine MRI data, but it lacks the ability to quantify the sub-voxel motion field in physical units. Here, we introduce...

  • Article
  • Open Access
2 Citations
2,623 Views
10 Pages

The purpose of this study was to assess the biomechanical adaptations prompted by stationary cycling paired with visual feedback of vertical pedal reaction forces during both stationary cycling and overground walking for patients who underwent a tota...

  • Article
  • Open Access
1,658 Views
13 Pages

Background: The purpose of this study was to compare geographic atrophy (GA) area semi-automatic measurement using fundus autofluorescence (FAF) versus optical coherence tomography (OCT) annotation with the cRORA (complete retinal pigment epithelium...

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Bioengineering - ISSN 2306-5354