Skip to Content

Chemosensors, Volume 14, Issue 10

2026 October - 30 articles

Cover Story: Fourier-transform infrared (FT-IR) spectroscopy provides rapid, non-destructive molecular fingerprints, but spectral overlap and matrix effects hinder quantitative analysis. This review examines how artificial intelligence (AI), including machine learning, deep learning, and explainable AI (XAI), converts complex FT-IR spectra into quantitative predictions and interpretable chemical information. It covers preprocessing, model development, independent validation, uncertainty, and spectral feature attribution. Applications include composition and concentration prediction, adulteration and contamination assessment, material-property evaluation, and process monitoring. The review emphasizes robust validation, transferability, and chemically grounded interpretation as foundations for reliable AI-assisted FT-IR sensing. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (30)

  • Review
  • Open Access
261 Views
44 Pages

Intelligent gas sensors (IGSs) have garnered significant attention owing to their highly sensitive, selective, and reliable gas detection in industrial safety, environmental monitoring, food quality assessment, healthcare diagnostics, and smart Inter...

(This article belongs to the Special Issue Advanced Materials and Emerging Technologies for Gas and Humidity Sensors)
  • Perspective
  • Open Access
262 Views
27 Pages

Paper-based colorimetric glucose sensing has evolved from simple visual assays toward digitally quantified systems increasingly supported by artificial intelligence (AI). However, advanced computational analysis cannot fully compensate for limitation...

(This article belongs to the Section Applied Chemical Sensors)
  • Article
  • Open Access
220 Views
18 Pages

A Sustainable Fe-MOF@N-Doped Graphite Electrochemical Platform for Sensitive Dothiepin Determination in Human Plasma

  • Mona A. Abdel Rahman,
  • Aya A. Mouhamed,
  • Ola G. Hussein,
  • Mahmoud A. Tantawy and ,
  • Suliman A. Almahmoud,
  • Amr M. Mahmoud and
  • Eman M. Moaaz
  • + 2 authors+ 0 author

Accurate monitoring of antidepressant drugs is essential for ensuring therapeutic efficacy and minimizing adverse effects, creating a demand for sensitive and reliable analytical methodologies. In the present study, a novel electrochemical sensor was...

(This article belongs to the Section Electrochemical Devices and Sensors)
  • Review
  • Open Access
171 Views
23 Pages

Recent Advances in Near-Infrared II-Emitting Carbon Dots for Ultrasensitive Detection of Disease-Related Biomarkers

  • Kaiqiang Zeng,
  • Siqi Liu,
  • Shuyuan Jia,
  • Deyu Liu and ,
  • Qing Kang,
  • Hong Zhao,
  • Jinjing Li,
  • Wensheng Liu,
  • Jian-Hua Zhang and
  • Yang Teng
  • + 5 authors+ 0 author

Carbon dots (CDs) have emerged as widely used functional nanomaterials in biomedical sensing due to their tunable fluorescence emission wavelength, excellent biocompatibility, and ease of functional modification. Fluorescent CDs operating in the near...

(This article belongs to the Special Issue Emerging Functional Nanomaterials for Biosensors and Chemical Sensors)
  • Review
  • Open Access
262 Views
30 Pages

DNA Logic-Gated Biosensing of the Tumor Microenvironment for Multicomponent Profiling and Programmable Molecular Decision-Making

  • Minghan Li,
  • Yinuo Chen,
  • Yihang Du,
  • Yicong Li and ,
  • Jinpeng Shi,
  • Jie Tong,
  • Yinan Li,
  • Jiashuang Xu,
  • Qiuyue Wu and
  • Xingrui Li
  • + 6 authors+ 1 author

The tumor microenvironment (TME) is spatially and temporally heterogeneous, limiting the specificity of single-biomarker strategies for resolving complex tumor states. The sequence programmability and predictable base pairing of DNA allow multiple bi...

(This article belongs to the Special Issue Advanced Biosensors for Diagnostic Applications)
  • Article
  • Open Access
153 Views
22 Pages

Quantitative Analysis of Four Active Components in Wine-Processed Scutellaria baicalensis by Data Fusion Strategy Coupled with Multivariate Statistical Analysis

  • Shengsheng Wang,
  • Xulong Peng,
  • Tian Yao,
  • Qingzhao Wan and ,
  • Tulin Lu,
  • Jing Zhu and
  • Yaqi Wang
  • + 2 authors+ 0 author

Wine-processed Scutellaria baicalensis is a processed Chinese herbal product obtained by wine-processing of raw S. baicalensis. Flavonoids are its core pharmacodynamic constituents with heat-clearing, anti-inflammatory, hepatoprotective and other bio...

(This article belongs to the Topic AI in Optical Spectroscopy Analysis)
  • Article
  • Open Access
119 Views
15 Pages

Porphyrins are typical macrocyclic conjugated compounds widely utilized for designing high-sensitivity and high-selectivity chemical sensors. Porphyrin macrocycles can self-assemble into uniform two-dimensional (2D) nanostructures on gold films via &...

(This article belongs to the Section Optical Chemical Sensors)
  • Article
  • Open Access
231 Views
33 Pages

Near-infrared spectroscopy supports rapid quantification of moisture, oil, protein, and starch in corn. Their prediction models may require different spectral inputs, complicating shared-variable selection. We developed the multicomponent shared wave...

(This article belongs to the Section Optical Chemical Sensors)
  • Review
  • Open Access
431 Views
39 Pages

The demand for non-destructive evaluation of agricultural products has stimulated the emergence of multimodal sensing technologies capable of integrating diverse quality- and safety-related information. Recent advances in multimodal sensing and machi...

(This article belongs to the Special Issue Application of Chemical Sensors in Smart Agriculture)
  • Article
  • Open Access
217 Views
16 Pages

A Portable Smartphone-Assisted Fluorescence Sensing Platform Based on Molecularly Imprinted Lanthanide MOF for Rapid Determination of Thiamethoxam in Vegetables

  • Run Gao,
  • Li Zhao,
  • Lin Ma,
  • Yinan Chen and ,
  • Jialuo Mao,
  • Xiuxiu Wu,
  • Jinsong Yu and
  • Hui Cao
  • + 3 authors+ 0 author

Thiamethoxam is a widely used neonicotinoid insecticide in agriculture, and its excessive use has raised growing concerns about food safety and environmental pollution. In this study, a portable fluorescence sensing platform was developed for the rap...

(This article belongs to the Section Optical Chemical Sensors)
  • Review
  • Open Access
247 Views
23 Pages

Wearable health monitoring is expanding from physical signals, such as heart rate and body temperature, to molecular information at body interfaces and in biofluids. Raman spectroscopy provides chemically specific vibrational fingerprints and support...

(This article belongs to the Special Issue Innovative Wearable and Implantable Electrochemical Sensors)
  • Review
  • Open Access
234 Views
30 Pages

Background: Astronauts operating in extravehicular activity (EVA) and intravehicular activity (IVA) suits are exposed to a closed, thermally demanding microenvironment in which sweat accumulation, hydration status, skin-barrier disturbance, optical-s...

(This article belongs to the Section Applied Chemical Sensors)
  • Article
  • Open Access
235 Views
15 Pages

DFT Investigation on the Adsorption and Sensing Mechanisms of Transformer Fault Gases over MOF-Based Cu-BTC and ZIF-8

  • Yunhua He,
  • Yuhang Xie,
  • Xin Zheng,
  • Hanyu Li and ,
  • Xianfeng Lang and
  • Yongsheng Luo
  • + 1 author+ 0 author

Real-time detection of the six characteristic gases dissolved in transformer oil (H2, CO, CO2, CH4, C2H4, C2H2), present from sub-ppm levels for C2H2 to several thousand ppm for CO2, is essential for early fault diagnosis in oil-immersed power equipm...

(This article belongs to the Special Issue Advanced Materials for Gas Sensing Applications: From First-Principles Insights to Real-World Applications)
  • Review
  • Open Access
1 Citations
306 Views
39 Pages

Quinones as Optical Signal Transducers: Emerging Roles in Spectroscopic Sensing, Carbon Dots, and Enzyme-Free Immunoassays

  • Mahmoud El-Maghrabey,
  • Rania El-Shaheny,
  • Ali Abdel-Hakim,
  • Helal F. Hetta and
  • Naoya Kishikawa

Quinones have emerged as versatile optical signal transducers in spectroscopic analytical chemistry because of their unique redox activity, electron-transfer capability, reactive oxygen species generation, and tunable photophysical properties. Beyond...

(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2026)
  • Article
  • Open Access
187 Views
21 Pages

Pt-Functionalized SnO2 Hollow Nanotubular Structures for H2S Sensing: Experimental Investigation and DFT Insights

  • Hui Li,
  • Yuhao Qiu,
  • Xuxu Wang,
  • Banglei Liang and ,
  • Zongtao Wang,
  • Yingying Dong and
  • Qiao Feng
  • + 2 authors+ 0 author

Pt-functionalized SnO2 hollow nanotubular structures were fabricated by single-nozzle electrospinning followed by calcination and evaluated for H2S sensing. At an operating temperature of 350 °C, the 2 wt% Pt/SnO2 sensor exhibited a response of 5...

(This article belongs to the Special Issue Innovative Gas Sensors: Development and Application)
  • Article
  • Open Access
258 Views
27 Pages

Integration of Electronic Nose Profiles from Breath, Urine, and Axillary Sweat for Colorectal Cancer Classification

  • Gustavo Adolfo Bautista Gomez,
  • Cristhian Manuel Durán Acevedo and
  • Jeniffer Katerine Carrillo Gómez

Electronic noses provide a pattern-based approach for investigating volatile profiles associated with colorectal cancer; however, the combined analysis of participant-matched sensor profiles from different biological matrices remains largely unexplor...

(This article belongs to the Section Applied Chemical Sensors)
  • Review
  • Open Access
276 Views
29 Pages

Sensing Mechanisms of GPCR- and OBP-Based Biosensors for Addictive Drug Detection

  • Li Sin Wong,
  • Xiaojing Zhang,
  • Yanran Xia,
  • Xinrui Tang and ,
  • Hongyang Guo,
  • Hongjian Zhang,
  • Ping Wang,
  • Boyang Xu and
  • Liujing Zhuang
  • + 4 authors+ 0 author

Addictive drug abuse remains a major global public health concern, creating a need for rapid and reliable approaches for drug screening and on-site analysis. Conventional analytical techniques provide accurate chemical identification but generally re...

(This article belongs to the Section (Bio)chemical Sensing)
  • Review
  • Open Access
310 Views
16 Pages

Recent Advances in the Application of Anthrone-Based Fluorescent Sensors for Helminth Imaging

  • Ligita Mežaraupe,
  • Evita Romanovska-Dzalbe,
  • Sanita Kecko,
  • Muza Kirjušina and ,
  • Veronika Pavlova,
  • Elena Kirilova and
  • Ilze Rubenina
  • + 2 authors+ 0 author

Fluorescence imaging has emerged as a transformative tool in parasitological research, providing high-contrast visualization of complex morphologies often obscured in traditional bright-field microscopy. This review article synthesizes recent advance...

(This article belongs to the Special Issue Feature Review Papers in Chemical/Bio-Sensors and Analytical Chemistry in 2026)
  • Article
  • Open Access
228 Views
14 Pages

Gas-Sensing Properties of CO2, CO, SO2, and H2S on an SbP Monolayer Based on Density Functional Theory

  • Xianchen Wang,
  • Yuanzhi Chen,
  • Zhengkang Yu,
  • Yongting Zhang and ,
  • Qiang Fu and
  • Keliang Wang
  • + 1 author+ 0 author

The sensing and detection of toxic and hazardous gases represents a critical technology in urgent need of development. Herein, density functional theory is employed to explore the adsorption characteristics and electronic response of CO2, CO, SO2, an...

(This article belongs to the Section Materials for Chemical Sensing)
  • Article
  • Open Access
242 Views
21 Pages

Protein-based biosensors exploit the extraordinary selectivity of proteins toward specific ligands—such as other proteins, ions, and electromagnetic signals—often surpassing engineered recognition systems. Ligand binding induces structura...

(This article belongs to the Special Issue Nanomaterials in Chemosensors and Biosensors: Development and Application (2nd Edition))
  • Article
  • Open Access
266 Views
15 Pages

A New Potentiometric Fluconazole-Selective Sensor Based on a Molecularly Imprinted Polymer

  • Mateja Budetić,
  • Korina Krejča,
  • Andrea Dandić,
  • Aleksandar Széchenyi and
  • Mirela Samardžić

29 September 2026

Fluconazole (FLU) is a widely used antifungal drug, and its reliable determination is important for quality control in pharmaceutical analysis. This study aimed to develop a simple and accurate FLU-selective potentiometric sensor based on a molecular...

(This article belongs to the Special Issue Potentiometric Sensors in Analytical Chemistry)
  • Article
  • Open Access
405 Views
12 Pages

Olfactory Signatures of Bladed Weapons: Characterization and Implications for Canine Detection

  • Courtney Ann McGuire,
  • Istvan Balogh,
  • Brian Mence and
  • Paola A. Prada-Tiedemann

28 September 2026

Knife crime has increased globally, yet the effectiveness of current detection methods used by law enforcement is often limited in operational settings. This challenge highlights the need for innovative detection approaches. The use of canines as hig...

(This article belongs to the Special Issue Chemical Sensors for Volatile Organic Compound Detection, 3rd Edition)
  • Article
  • Open Access
234 Views
18 Pages

A Direct Fuel Cell–Chemometric Platform for Quantitative Analysis and Exploratory Differentiation of Pharmaceutical and Biomedical Compounds

  • Mauro Tomassetti,
  • Federico Marini,
  • Mauro Castrucci,
  • Marco Petrangeli Papini and
  • Luigi Campanella

28 September 2026

A simple, low-cost analytical platform based on a commercial direct methanol–ethanol fuel cell (D(M–E)FC) combined with chemometric data analysis is investigated for the quantitative analysis and exploratory differentiation of pharmaceuti...

(This article belongs to the Section Analytical Methods, Instrumentation and Miniaturization)
  • Article
  • Open Access
346 Views
17 Pages

An Integrated Workflow for Activity-Associated Constituent Prioritization and Candidate Quality Marker Evaluation in Complex Herbal Medicines

  • Xiaojuan Zhou,
  • Hui Zhuge,
  • Bo Ma,
  • Zhiwei Ge and ,
  • Li Che,
  • Lihua Yang,
  • Xiyi Chen,
  • Cheng Jiang,
  • Shujing Zhang and
  • Yu Tang
  • + 8 authors+ 3 authors

28 September 2026

Herbal medicines (HMs) are chemically complex multi-component systems, yet analytical strategies that systematically connect chemical composition, biological activity, target prioritization, and quantitative analysis remain limited. Here, we establis...

(This article belongs to the Special Issue Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition)
  • Article
  • Open Access
265 Views
14 Pages

A Highly-Sensitive Electrode with Tubular Structure for the Detection of AA in Orange Juice

  • Jiao Yang,
  • Chao Yang,
  • Chunyan Cao,
  • Shengde Yang and ,
  • Shisong Huang,
  • Yulan Jian and
  • Jie Ding
  • + 2 authors+ 0 author

25 September 2026

In this work, a three-dimensional (3D) tubular composite electrode was fabricated for the high-sensitivity electrochemical detection of ascorbic acid (AA). The differential pulse voltammetry (DPV) was employed to investigate the electrochemical behav...

(This article belongs to the Special Issue Recent Developments in Electrode Materials for Electrochemical Sensing)
  • Article
  • Open Access
251 Views
14 Pages

Simplified Synthesis of Blue Light-Emitting CdSe/ZnS Core–Shell Quantum Dots

  • Yi-Zhi Lin,
  • Sheng-Tong Wu,
  • Zi-Chen Pan and
  • Shou-Nian Ding

24 September 2026

Blue-emitting CdSe/ZnS quantum dots require precise control of crystal growth because variations in particle size and surface structure can strongly influence their emission properties. In this study, blue-optical CdSe/ZnS core–shell quantum do...

(This article belongs to the Section Optical Chemical Sensors)
  • Article
  • Open Access
343 Views
20 Pages

Green-Synthesized CuO Nanoparticles from Pomegranate Peel for Dual Electrochemical Detection and Adsorptive Removal of Tetracycline

  • Youssef O. Al-Ghamdi,
  • Amani Chrouda,
  • Manahil Babiker Elamin,
  • Sabri Messaoudi and ,
  • Hamdi Ben Halima and
  • Nicole Jaffrezic-Renault
  • + 1 author+ 0 author

24 September 2026

Green nanomaterials have attracted considerable attention for environmental monitoring due to their sustainability and multifunctional properties. In this study, copper oxide nanoparticles were synthesized using pomegranate peel (pp) extract (CuO@PP)...

(This article belongs to the Section Electrochemical Devices and Sensors)
  • Review
  • Open Access
362 Views
24 Pages

23 September 2026

Fourier-transform infrared (FT-IR) spectroscopy provides rapid, accessible, and chemically informative molecular fingerprints, but quantitative analysis of complex samples is often hindered by band overlap, baseline variation, matrix effects, and non...

(This article belongs to the Topic AI in Optical Spectroscopy Analysis)
  • Article
  • Open Access
323 Views
17 Pages

In Situ Determination of Chloride Ions Using a Novel Double-Layer Membrane Optical Fiber Sensor Modified with the UiO-66-NH2/Lucigenin Complex

  • Hongxi Wang,
  • Maolong Chen,
  • Runqi Yao,
  • Jixing Huang and ,
  • Jiangbo Zhao and
  • Liyun Ding
  • + 1 author+ 0 author

23 September 2026

Chloride quantification is crucial for environmental monitoring, marine research, and the durability assessment of geotechnical infrastructures, yet accurate measurement in complex aqueous and soil matrices remains challenging. Optical fiber sensors...

(This article belongs to the Section Optical Chemical Sensors)
  • Article
  • Open Access
346 Views
21 Pages

Dual-Feedback Adaptive Wavelet Packet Thresholding for Denoising IoT Gas Sensor Signals

  • Xiujuan Feng,
  • Chuhao Huang,
  • Liangji Xu,
  • Lindani Ncube and
  • Haotong Guo

22 September 2026

To address the dual challenges of environmental temperature–humidity fluctuations and spurious impulse artifacts in real-time IoT monitoring, this paper proposes a novel digital sensor signal denoising method based on wavelet packet decompositi...

(This article belongs to the Special Issue Chemical Sensors for Volatile Organic Compound Detection, 3rd Edition)
XFacebookLinkedIn
Chemosensors - ISSN 2227-9040