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Chemosensors
Special Issues
Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition
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Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Analytical Methods, Instrumentation and Miniaturization".

Deadline for manuscript submissions: 15 September 2026 | Viewed by 1535

Special Issue Editors

Prof. Dr. Yi Wang

E-Mail Website
Guest Editor
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310012, China
Interests: drug discovery from natural products; high content screening
Special Issues, Collections and Topics in MDPI journals
Dr. Xingchu Gong

E-Mail Website
Guest Editor
Pharmaceutical Informatics Institute, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China
Interests: traditional Chinese medicine quality control; pharmaceutical engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Analysis of raw materials and excipients in pharmaceutical processes, as well as their preparation, plays a pivotal role in the quality control of drugs. In recent years, various bionic sensors have been developed to increase the sensitivity and efficiency of such analysis. Spectral technology, assisted by chemometrics and artificial intelligence, is also employed for the efficient monitoring of pharmaceutical processes. Furthermore, nondestructive analytical technologies are increasingly being adopted, such as machine vision and acoustic emission. Lower-cost and greener analytical technology has also experienced rapid development, and the quality by design approach has led to further analytical innovation.

Our previous SI, “Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis”, successfully published 9 papers. For this Special Issue, “Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition”, we invite the submission of high-quality multidisciplinary research and reviews considering any and all aspects of innovative analytical methods focused on pharmaceutical and biomedical analysis.

Prof. Dr. Yi Wang
Dr. Xingchu Gong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • AI-assisted analysis
  • biosensors and chemosensors
  • mass spectrometry
  • nuclear magnetic resonance
  • Raman spectrum
  • near-infrared spectroscopy
  • lab-on-chip
  • novel materials and devices for sample pretreatment
  • analytical quality by design
  • nondestructive analytical technology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

15 pages, 594 KB  
Article
Trace-Level Determination of ACE Inhibitors in Wastewater of Al-Kharj Governorate Using Solid-Phase Extraction–Capillary Electrophoresis Aided by Field Amplified Sample Stacking: A Sustainable Analytical Approach
by Alhumaidi B. Alabbas and Sherif A. Abdel-Gawad
Chemosensors 2026, 14(6), 129; https://doi.org/10.3390/chemosensors14060129 - 4 Jun 2026
Abstract
Particularly in regions experiencing rapid industrial and healthcare development, the presence of pharmaceutical residues in wastewater is becoming an increasingly pressing environmental concern. In this study, an analytical method was developed to quantify lisinopril (LIS), ramipril (RAM), and enalapril (ENA) in wastewater while [...] Read more.
Particularly in regions experiencing rapid industrial and healthcare development, the presence of pharmaceutical residues in wastewater is becoming an increasingly pressing environmental concern. In this study, an analytical method was developed to quantify lisinopril (LIS), ramipril (RAM), and enalapril (ENA) in wastewater while being both sensitive and inexpensive. To improve the precision and accuracy of the measurements, propranolol (PRO) was used as an internal standard. To achieve dual preconcentration and enhanced sensitivity, the method integrates filed amplified sample stacking (FASS) with solid-phase extraction (SPE) before capillary electrophoresis (CE) in a synergistic way. Important experimental factors such the composition of the background electrolyte (BGE), pH, injection settings, stacking efficiency, and selection of the SPE sorbent were meticulously calibrated. Under ideal circumstances, the SPE-CE-FASS method demonstrated remarkable linearity within the concentration range of 10–1000 ng L−1 (R2 > 0.999), an outstanding level of accuracy (intra- and inter-day RSD < 6%), and satisfactory recovery percents (90–97%) in real wastewater samples. This method offers an eco-friendly and cost-effective alternative to liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) by reducing waste, using less solvent, and providing enough sensitivity for trace-level analysis. Hence, it is very suitable for the regular monitoring of angiotensin converting enzyme (ACE) inhibitors in complex wastewater matrices. Full article
(This article belongs to the Special Issue Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition)
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21 pages, 4744 KB  
Article
Highly Sensitive Detection of Phenylbutazone with Metallic Particle-Based Electrochemical Sensors
by Ana-Raluca Măghinici, Andreea-Loredana Comănescu, Andrei-Daniel Geman and Constantin Apetrei
Chemosensors 2026, 14(4), 88; https://doi.org/10.3390/chemosensors14040088 - 3 Apr 2026
Viewed by 521
Abstract
Nonsteroidal anti-inflammatory drugs such as phenylbutazone (PBZ) are among the most widely used medications globally due to their effectiveness in relieving pain and reducing inflammation. This study aims to detect PBZ with metallic particle-based electrochemical sensors using cyclic voltammetry (CV) in the presence [...] Read more.
Nonsteroidal anti-inflammatory drugs such as phenylbutazone (PBZ) are among the most widely used medications globally due to their effectiveness in relieving pain and reducing inflammation. This study aims to detect PBZ with metallic particle-based electrochemical sensors using cyclic voltammetry (CV) in the presence of catechol as a redox probe. The approach focuses on evaluating the electrochemical behaviour of PBZ under different experimental conditions and optimizing the detection parameters to develop a simple, rapid, and cost-effective analytical method suitable for this pharmaceutical compound in lab practice. CV was performed using four types of screen-printed electrodes, each modified with different transitional metal particles, in potassium ferrocyanide/potassium ferricyanide, catechol, and catechol-PBZ solutions to study the electrochemical response and detection capability for PBZ. The best performance characteristics were obtained for the sensor modified with Ir particles that detect PBZ, with a linearity range of 0.01 to 1.00 μM and a detection limit of 1.53 nM. Additionally, Fourier-transform infrared spectroscopy (FT-IR) was used to characterize the PBZ in pharmaceuticals. The method using an iridium-modified sensor developed in this study allows the accurate detection of PBZ in pharmaceuticals with a relative error lower than 4%. Full article
(This article belongs to the Special Issue Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition)
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14 pages, 900 KB  
Article
Pollution Monitoring of Paracetamol, Ibuprofen, and Diclofenac in Pharmaceutical Wastewater from Al-Kharj Governorate Using FASS-SPE Enhanced Capillary Electrophoresis
by Alhumaidi B. Alabbas and Sherif A. Abdel-Gawad
Chemosensors 2026, 14(4), 79; https://doi.org/10.3390/chemosensors14040079 - 1 Apr 2026
Viewed by 649
Abstract
Pharmaceutical residues in aquatic environments represent a significant pollution concern, particularly in regions experiencing rapid healthcare and industrial growth. This study presents a sensitive and environmentally sustainable analytical method for monitoring paracetamol (PAR), ibuprofen (IBU), and diclofenac sodium (DIC) in pharmaceutical wastewater from [...] Read more.
Pharmaceutical residues in aquatic environments represent a significant pollution concern, particularly in regions experiencing rapid healthcare and industrial growth. This study presents a sensitive and environmentally sustainable analytical method for monitoring paracetamol (PAR), ibuprofen (IBU), and diclofenac sodium (DIC) in pharmaceutical wastewater from Al-Kharj Governorate, Saudi Arabia. The method integrates off-line solid-phase extraction (SPE) with field-amplified sample stacking (FASS) prior to capillary electrophoresis (CE), enabling effective dual preconcentration and enhanced detection sensitivity. Key parameters affecting separation and enrichment, including background electrolyte composition, pH, injection conditions, stacking efficiency, and SPE sorbent selection, were systematically optimized. Under optimal conditions, the SPE–CE–FASS method demonstrated excellent linearity (r2 ≥ 0.997) over the concentration range of 10–1000 ng L−1, with strong precision (intra- and inter-day RSD ≤ 6%) and high recoveries (91.8–98.5%) in pharmaceutical wastewater samples. Matrix-based limits of detection were 4.0 ng L−1 for PAR, 3.5 ng L−1 for IBU, and 3.0 ng L−1 for DIC. The method was successfully applied to real wastewater samples, where all target analytes were detected at environmentally relevant concentrations. Owing to its low solvent consumption, reduced waste generation, and high sensitivity, the proposed SPE–CE–FASS method offers a reliable, cost-effective, and environmentally friendly approach for routine monitoring of pharmaceutical residues in complex wastewater matrices. Full article
(This article belongs to the Special Issue Innovative Analytical Methods in Pharmaceutical and Biomedical Analysis, 2nd Edition)
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