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Chemosensors
Special Issues
Nanomaterials in Chemosensors and Biosensors: Development and Application (2nd Edition)
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Nanomaterials in Chemosensors and Biosensors: Development and Application (2nd Edition)

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Materials for Chemical Sensing".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 5522

Special Issue Editors

Dr. Marko Spasenovic

E-Mail Website
Guest Editor
Center for Microelectronic Technologies, Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, 11000 Belgrade, Serbia
Interests: graphene; sensors; photonics; material science
Special Issues, Collections and Topics in MDPI journals
Dr. Teodora Vicentic

E-Mail Website
Guest Editor Assistant
Institute of Chemistry, Technology and Metallurg, University of Belgrade, 11000 Belgrade, Serbia
Interests: graphene; laser-induced graphene; wearable sensors; flexible electronics; biosensors; nanomaterials

Special Issue Information

Dear Colleagues,

The emergence of engineered nanomaterials has enabled novel applications in numerous fields, including healthcare, engineering, manufacturing, aerospace, construction, automotive, etc. The large surface-to-volume ratio of nanomaterials is well suited to targeted functionalization and sensing. Chemosensors’ and biosensors’ specificity and sensitivity can be tailored via changes in the engineering nanomaterial shape, size, composition and surface chemistry. Nanomaterial biosensors have applications in healthcare diagnostics, food freshness retention, bioprocessing, etc. Materials falling under this category, including metals, metal oxides, carbon nanotubes, 2D materials, polymers, proteins and nanocomposites, can have varied compositions. Chemosensors can be used to detect gases and liquids for applications in environmental protection, industrial automation and safety. This Special Issue covers all aspects of such materials, ranging from theoretical considerations explaining the working principles of materials to their synthesis, characterization and application.

Dr. Marko Spasenovic
Guest Editor

Dr. Teodora Vićentić
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Chemosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • chemosensors
  • biosensors
  • nanotechnology
  • biotechnology

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Published Papers (3 papers)

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Research

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16 pages, 9156 KB  
Article
Spiropyran-Modified Cellulose for Dual Solvent and Acid/Base Vapor Sensing
by Daniel D. S. de Sá, João P. C. Trigueiro, Luiz F. C. de Oliveira, Hernane S. Barud, Frank Alexis, Roberto S. Nobuyasu, Flávio B. Miguez and Frederico B. De Sousa
Chemosensors 2026, 14(1), 17; https://doi.org/10.3390/chemosensors14010017 - 4 Jan 2026
Viewed by 1199
Abstract
Stimuli-responsive materials based on renewable biopolymers are highly attractive for developing sustainable chemical sensors. Here, two spiropyran derivatives (SP1 and SP2) were synthesized and covalently grafted onto cellulose, yielding the functional materials Cel-SP1 and Cel-SP2. Cellulose was selected [...] Read more.
Stimuli-responsive materials based on renewable biopolymers are highly attractive for developing sustainable chemical sensors. Here, two spiropyran derivatives (SP1 and SP2) were synthesized and covalently grafted onto cellulose, yielding the functional materials Cel-SP1 and Cel-SP2. Cellulose was selected as a biocompatible, biodegradable, and renewable support able to provide a stable, hydrogen-bond-rich microenvironment for chromic responses. Raman spectroscopy confirmed successful esterification, while SEM-EDS analyses revealed preserved cellulose morphology and the incorporation of nitrogen-rich spiropyran moieties. Both materials exhibited pronounced solvatochromic and pH-dependent behaviors in the solid state. Diffuse reflectance measurements revealed distinct bathochromic or hypsochromic shifts depending on solvent polarity and specific solute–matrix interactions, with DMF and DMSO producing the strongest responses. Under acidic vapors, both materials generated new absorption bands consistent with the formation of protonated merocyanine species, whereas basic vapors promoted partial or full reversion to the spiropyran form. Cel-SP1 and Cel-SP2 also displayed solvent- and pH-dependent luminescence, with Cel-SP2 showing a markedly higher sensitivity to protonation. Prototype solvent strips and acid/base vapor indicators demonstrated fast, naked-eye, reversible chromic transitions. These results highlight spiropyran-modified cellulose as an effective, renewable platform for dual solvent and acid/base vapor sensing. Full article
(This article belongs to the Special Issue Nanomaterials in Chemosensors and Biosensors: Development and Application (2nd Edition))
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12 pages, 4335 KB  
Article
ZnS Nanomaterials with Hexagon and Pentagon Structures: Effect of Surfactants on Surface Morphology and Biosensing Application
by Antony Ananth, Ihn Han, Eun Ha Choi and Jin-Hyo Boo
Chemosensors 2025, 13(12), 419; https://doi.org/10.3390/chemosensors13120419 - 4 Dec 2025
Viewed by 713
Abstract
Zinc sulfide nanomaterials (ZnS NMs) are widely used in many important technological applications, and the performance efficiency is determined by the nanostructure, size, and shape. This indicates that achieving a desirable surface architecture is pivotal for any application. One of the efficient and [...] Read more.
Zinc sulfide nanomaterials (ZnS NMs) are widely used in many important technological applications, and the performance efficiency is determined by the nanostructure, size, and shape. This indicates that achieving a desirable surface architecture is pivotal for any application. One of the efficient and cost-effective techniques, the hydrothermal method, offers uniform size, specific shape, and bulk synthesis capability. This research deals with the preparation of ZnS NMs exhibiting unique surface structures such as spherical, nano-pentagon, and nano-hexagon shapes through employing different zinc precursors and surfactants. The obtained material’s crystal structure was classified as cubic sphalerite and exhibited high purity, as analyzed by XRD, SEM-EDX, TEM, and XPS. Furthermore, the synthesized ZnS NMs were tested for their shape-dependent biosensing application, such as specific antibacterial tests against routine human pathogens such as E. coli, K. pneumoniae, and S. aureus. Several antibacterial methods, such as bacterial colony plate count, growth inhibition analysis, and minimum inhibition concentration (MIC) measurements were carried out. The results confirmed that the antibacterial action in the method employed was dependent on three factors: the NM shape, concentration, and type/nature of bacteria. Especially, the prepared ZnS NMs exhibited excellent antibacterial sensing characteristics, as observed from the lower MIC values in the range of 15.6~250 µg/mL. Full article
(This article belongs to the Special Issue Nanomaterials in Chemosensors and Biosensors: Development and Application (2nd Edition))
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Review

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23 pages, 3726 KB  
Review
Tracking PFAS Using Nanomaterial-Based Sensors: Limitations, Advances, and Challenges
by Anđela Gavran, Snežana Uskoković-Marković, Bojana Nedić Vasiljević, Aleksandra Janošević Ležaić, Nemanja Gavrilov, Maja Milojević-Rakić and Danica Bajuk-Bogdanović
Chemosensors 2025, 13(12), 421; https://doi.org/10.3390/chemosensors13120421 - 5 Dec 2025
Cited by 5 | Viewed by 3160
Abstract
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging contaminants of global concern, requiring sensitive and highly selective detection methods. Stringent demands imposed by the Environmental Protection Agency, with maximum contaminant levels set at 4.0 parts per trillion for PFAS individually in drinking water, are [...] Read more.
Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are emerging contaminants of global concern, requiring sensitive and highly selective detection methods. Stringent demands imposed by the Environmental Protection Agency, with maximum contaminant levels set at 4.0 parts per trillion for PFAS individually in drinking water, are the primary driving force behind the development of novel sensors for PFAS. Pushing towards these ultra-low concentrations, however, reaches the limit of what can be reliably detected by field sensors, with PFAS optical and electrochemical inactivity, making it nearly impossible. Molecularly imprinted polymers and immunoassays offer the best chance of developing such sensors as they interact specifically with the active site, changing the optical or electrochemical response (fluorescence, impedance, voltage). Nanoparticulate metal oxides, carbon materials, including carbon dots, polymer coating, and MXenes have been put forward; however, several of these approaches have failed to achieve either the desired limit of detection, sensitivity, or selectivity. Here, we provide an overview of recent progress in nanomaterial-based PFAS sensors, with particular emphasis on strategies to enhance sensitivity, selectivity, and reliability in complex matrices. Finally, we outline key challenges and future perspectives toward robust, field-deployable PFAS sensing technologies. Full article
(This article belongs to the Special Issue Nanomaterials in Chemosensors and Biosensors: Development and Application (2nd Edition))
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