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Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials

Josip Juraj Strossmayer University, Faculty of Food Faculty Osijek, 31000 Osijek, Croatia
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Biomolecules 2020, 10(1), 151; https://doi.org/10.3390/biom10010151
Received: 11 December 2019 / Revised: 14 January 2020 / Accepted: 14 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Perspectives of Coumarins)
The study of coumarin dates back to 1820 when coumarin was first extracted from tonka bean by Vogel. Compounds containing coumarin backbone are a very important group of compounds due to their usage in pharmacy and medicine. Properties and biological activities of coumarin derivatives have a significant role in the development of new drugs. Therefore, many different methods and techniques are developed in order to synthesize coumarin derivatives. Coumarin derivatives could be obtained from different starting materials with various methods but with big differences in yield. This review summarized various methods, techniques and reaction conditions for synthesis of coumarins from different compounds such as aldehydes, phenols, ketones and carboxylic acids.
Keywords: synthesis; coumarins; Knoevenagel condensation; Pechmann reaction synthesis; coumarins; Knoevenagel condensation; Pechmann reaction
MDPI and ACS Style

Lončarić, M.; Gašo-Sokač, D.; Jokić, S.; Molnar, M. Recent Advances in the Synthesis of Coumarin Derivatives from Different Starting Materials. Biomolecules 2020, 10, 151.

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