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Open AccessReview

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

1
National Center of Supervision Inspection on Processed Food & Food Additives Quality, Nanjing Institute of Product Quality Inspection, Nanjing 210019, China
2
School of Basic Medical Sciences, Nanjing Medical University, Nanjing 211166, China
3
School of Life Sciences, Nanjing University, Nanjing 210023, China
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 146; https://doi.org/10.3390/biom10010146 (registering DOI)
Received: 1 December 2019 / Revised: 13 January 2020 / Accepted: 14 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Phytochemical Omics in Medicinal Plants)
The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects. View Full-Text
Keywords: medicinal plants; bioactive compounds; herbs; biological activity; 4-hydroxynonenal; deleterious effects medicinal plants; bioactive compounds; herbs; biological activity; 4-hydroxynonenal; deleterious effects
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MDPI and ACS Style

Wang, F.-X.; Li, H.-Y.; Li, Y.-Q.; Kong, L.-D. Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects? Biomolecules 2020, 10, 146.

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