Biomolecules, Volume 10, Issue 2 (February 2020) – 186 articles
Cover Story (view full-size image): The bacterial flagellum is a motility organelle consisting of a long helical filament as a propeller and a rotary motor. Salmonella enterica has two genes of flagellin, fljB and fliC, for flagellar filament formation and autonomously switches their expression. Salmonella strain expressing FljB has shown a higher motility than the one expressing FliC under high viscosity. Our structural analysis by electron cryomicroscopy revealed that the structures of FljB and FliC filaments are nearly identical except for the position, orientation, and dynamics of the outermost domain D3 of flagellin, suggesting that domain D3 plays an important role not only in changing antigenicity of the filament but also in optimizing motility function of the filament as a propeller under different conditions. View this paper.
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