Special Issue "microRNA Biomarkers in Clinical Study"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 31 May 2020.

Special Issue Editors

Dr. Yi-Hau Chen
E-Mail Website
Guest Editor
Institute of Statistics, Academia Sinica, Taipei, Taiwan
Interests: biostatistics; bioinformatics; clinical data analysis
Prof. Hsiuying Wang
E-Mail Website
Guest Editor
Affiliation: Institute of Statistics, National Chiao Tung University, Hsinchu,Taiwan
Interests: anti-NMDA receptor encephalitis; microRNA; molecular biomarkers; phylogenetic analysis
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs), short non-coding RNAs, are involved in the initiation and progression of many human diseases that also play a key role in immune response and drug metabolism modulation. In recent years, miRNA functions have been examined in vitro and in vivo model systems, with miRNA biomarkers, miRNA regulatory networks and miRNA pathways being identified. Also, miRNA therapeutics have been developed. miRNAs can be detected in almost body fluids such as blood. For the easy availability, differences in the levels of circulating miRNAs can effectively help diagnose disease and prognosticate clinical outcome and contribute to interindividual variability in treatment response. In addition, molecular biomarkers could offer an objective and quantitative measurement of disease state. Therefore, the diagnosis using miRNA profiling and the treatment using targeting specific miRNAs are useful to develop personalized medicine in the future. The analyses results that associate miRNA expression level with clinical data can provide a more objective outcome to explore the mechanism of disease. Therefore, this Special Issue invites submissions of reviews and original papers that cover any interesting miRNA topic on biomarker study, pathway analysis, clinical data analysis, case studies, and other related subjects.

Dr. Yi-Hau Chen
Prof. Hsiuying Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microRNA
  • biomarker
  • clinical study
  • precision medicine

Published Papers (1 paper)

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Research

Open AccessArticle
Gene Expression Profiling of MicroRNAs in HPV-Induced Warts and Normal Skin
Biomolecules 2019, 9(12), 757; https://doi.org/10.3390/biom9120757 - 21 Nov 2019
Abstract
: Infection with the human papillomavirus (HPV) is a common occurrence among the global population, with millions of new cases emerging on an annual basis. Dysregulated microRNA (miRNA) expression is increasingly being identified to play a role in a number of different diseases, [...] Read more.
: Infection with the human papillomavirus (HPV) is a common occurrence among the global population, with millions of new cases emerging on an annual basis. Dysregulated microRNA (miRNA) expression is increasingly being identified to play a role in a number of different diseases, especially in the context of high-risk HPV infection. The present study investigated the miRNA expression profiles of warts induced by low-risk HPV. In warts, miR-27b, miR-24-1, miR-3654, miR-647, and miR-1914 were downregulated while miR-612 was upregulated compared to normal skin. Using miRTargetLink Human, experimentally supported evidence was obtained showing that miR-27b targeted the vascular endothelial growth factor C (VEGFC) and CAMP-responsive element binding protein 1 (CREB1) genes. The VEGFC and CREB1 genes have been reported to be involved in tumorigenesis and wart formation, respectively. Similarly, the oxidized low-density lipoprotein receptor 1 (OLR1) gene, which plays an important role in the humoral immunity of the skin, and the plexin D1 (PLXND1) gene, which is highly expressed in tumor vasculature, were both found to be common targets of miR-27b, miR-1914, and miR-612. Full article
(This article belongs to the Special Issue microRNA Biomarkers in Clinical Study)
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