Next Article in Journal
Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells
Previous Article in Journal
Microglia Mediated Neuroinflammation: Focus on PI3K Modulation
Previous Article in Special Issue
The Emerging Role of Long Non-Coding RNAs in the Metastasis of Hepatocellular Carcinoma
Open AccessReview

A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds

1
Institute of Biological Science (Genetics and Molecular Biology), Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
2
Centre for Research in Biotechnology for Agriculture (CEBAR), University of Malaya, Kuala Lumpur 50603, Malaysia
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 138; https://doi.org/10.3390/biom10010138
Received: 30 August 2019 / Revised: 8 October 2019 / Accepted: 8 October 2019 / Published: 14 January 2020
(This article belongs to the Special Issue Antitumor Agents from Natural Sources)
There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different substituents to generate different structure–activity relationships. This review highlights the effectiveness of different functional groups known to have antimigration and antiproliferation activities, such as fluoro, methoxy, methyl, amino, hydroxy, nitro, bromo, chloro, methylamino, ethoxy, carbonyl, iodo, and trifluoromethyl groups. Additionally, the positioning of these functional groups plays an important role in their anticancer activities, which was evident in one of our studies comparing analogues of a natural compound. Thus, this review suggests future recommendations for the design and development of improved anticancer drugs with higher efficacy. View Full-Text
Keywords: substituent; synthesis; antimetastasis; structure-activity relationships; biotechnology substituent; synthesis; antimetastasis; structure-activity relationships; biotechnology
Show Figures

Figure 1

MDPI and ACS Style

Liew, S.K.; Malagobadan, S.; Arshad, N.M.; Nagoor, N.H. A Review of the Structure–Activity Relationship of Natural and Synthetic Antimetastatic Compounds. Biomolecules 2020, 10, 138.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop